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Compliance-adjusted estimates of aspirin effects in older persons in the ASPREE randomized trial
Am J Epidemiol. 2023 Aug 8:kwad168. doi: 10.1093/aje/kwad168. Online ahead of print.ABSTRACTThe ASPirin in Reducing Events in the Elderly (ASPREE) trial recruited 19,114 participants across Australia and the United States during 2010-14. Participants were randomized to receive either 100mg aspirin daily or matching placebo, with disability-free survival as the primary outcome. During a median 4.7 years of follow-up, 37% of participants in the aspirin group permanently ceased taking their study medication and 10% commenced open label aspirin (OLA). In the placebo group, 35% and 11% ceased study medication and commenced OLA,...
Source: Am J Epidemiol - August 8, 2023 Category: Epidemiology Authors: C L Smith J Kasza R L Woods J E Lockery B Kirpach C M Reid E Storey M R Nelson R C Shah S G Orchard M E Ernst A M Tonkin A M Murray J J McNeil R Wolfe Source Type: research

Effect of Low-Dose Aspirin Versus Placebo on Incidence of Anemia in the Elderly : A Secondary Analysis of the Aspirin in Reducing Events in the Elderly Trial
CONCLUSION: Low-dose aspirin increased incident anemia and decline in ferritin in otherwise healthy older adults, independent of major bleeding. Periodic monitoring of hemoglobin should be considered in older persons on aspirin.PRIMARY FUNDING SOURCE: National Institutes of Health and Australian National Health and Medical Research Council.PMID:37335992 | DOI:10.7326/M23-0675
Source: Annals of Internal Medicine - June 19, 2023 Category: Internal Medicine Authors: Zoe K McQuilten Le Thi Phuong Thao Sant-Rayn Pasricha Andrew S Artz Michael Bailey Andrew T Chan Harvey Jay Cohen Jessica E Lockery Anne M Murray Mark R Nelson Hans G Schneider Rory Wolfe Robyn L Woods Erica M Wood John J McNeil Source Type: research

Incidence of Thromboembolic Complications Following Kidney Transplantation with Short and Extended Aspirin Prophylaxis: A Retrospective Single-Center Study
CONCLUSIONS Extended-duration aspirin use did not significantly reduce the incidence of VTE in the first 6 weeks following kidney transplantation. An association was identified between anti-human thymocyte immunoglobulin and VTE, which requires further assessment.PMID:37309097 | DOI:10.12659/AOT.939143
Source: Annals of Transplantation - June 13, 2023 Category: Transplant Surgery Authors: Angus H Pegler Katharine Hegerty Ryan P Gately Carmel M Hawley David W Johnson Yeoungjee Cho Dev K Jegatheesan Andrew B McCann Michelle E Harfield Nicole M Isbel Source Type: research

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