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CAV-1 Overexpression Exacerbates the Manifestation in EPAC-1-Induced Chronic Postsurgical Pain in Rats
CONCLUSION: CAV-1 mediates the functional coupling of microglia, astrocytes, and neurons, and thus EPAC-1/CAV-1 plays an important role in CPSP exacerbation.PMID:35958678 | PMC:PMC9357801 | DOI:10.1155/2022/8566840
Source: Pain Research and Management - August 12, 2022 Category: Anesthesiology Authors: Qian Hua Shiren Shen Yibin Qin Su Cao Source Type: research

OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
Conclusions: The findings of this study suggest that the OPN deficiency can result in accelerated OA, which is associated with enhanced senescence and apoptosis of OA chondrocytes and the upregulated expressions of OA-associated genes. PMID: 33144900 [PubMed - in process]
Source: Pain Research and Management - November 6, 2020 Category: Anesthesiology Authors: Tian J, Cheng C, Kuang SD, Su C, Zhao X, Xiong YL, Li YS, Gao SG Tags: Pain Res Manag Source Type: research

Water-Soluble Polymer Assists N-Methyl-D-Aspartic Acid Receptor 2B siRNA Delivery to Relieve Chronic Inflammatory Pain In Vitro and In Vivo.
Abstract We constructed a water-soluble lipopolymer (WSLP) as a nonviral gene carrier to deliver siRNA targeting NR2B. The cytotoxicity and serum stability of WSLP loaded with siRNA were evaluated, and the knockdown efficiency of WSLP/NR2B-siRNA in PC12 cells was examined. The results showed that WSLP could protect the loading siRNAs from enzymatic degradation in serum and exhibit low cytotoxicity to cells. After transfection, WSLP/NR2B-siRNA complexes reduced the NR2B transcriptional level by 50% and protein level by 55% compared to control siRNA. Moreover, 3 days after intrathecal injection of WSLP/NR2B-siRNA co...
Source: Pain Research and Management - April 8, 2018 Category: Anesthesiology Authors: Peng J, Ma J, Yang X, He H, Wu H, Ma T, Lu J Tags: Pain Res Manag Source Type: research

Therapeutic potential of RNA interference in pain medicine.
Authors: Tan PH, Yang LC, Ji RR Abstract In recent years RNA interference (RNAi) has rapidly become the most widely used tool for gene knockdown due to its high specificity and potency. RNAi is an evolutionarily conserved mechanism for silencing gene expression by targeted degradation of mRNA. In the past decade, hundreds of molecular targets have been identified for their roles in pain modulation. But most molecular targets are not readily druggable with small molecules. RNAi represents a therapeutic approach applicable to these non-druggable targets. There is a rapid increase in the number of studies that use sma...
Source: Open Pain Journal - June 4, 2015 Category: Anesthesiology Tags: Open Pain J Source Type: research

Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., exhibits potent and specific antinociception in chronic pain by acting at spinal α3 glycine receptors
TOC summary: Gelsemine produces potent and specific antinociception in chronic pain states by activating spinal α3 glycine receptors without inducing tolerance.Abstract: The present study examined the antinociceptive effects of gelsemine, the principal alkaloid in Gelsemium sempervirens Ait. A single intrathecal injection of gelsemine produced potent and specific antinociception in formalin-induced tonic pain, bone cancer-induced mechanical allodynia, and spinal nerve ligation-induced painful neuropathy. The antinociception was dose-dependent, with maximal inhibition of 50% to 60% and ED50 values of 0.5 to 0.6μg. Multipl...
Source: Pain - July 24, 2013 Category: Anesthesiology Authors: Jing-Yang Zhang, Nian Gong, Jin-Lu Huang, Ling-Chen Guo, Yong-Xiang Wang Tags: Research papers Source Type: research