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Decoding the invasive nature of a tropical pathogen of concern: The invasive non-Typhoidal Salmonella strains causing host-restricted extraintestinal infections worldwide
Microbiol Res. 2023 Sep 12;277:127488. doi: 10.1016/j.micres.2023.127488. Online ahead of print.ABSTRACTInvasive-Non-Typhoidal Salmonella (iNTS) are the major cause of health concern in the low-income, under-developed nations in Africa and Asia that lack proper sanitation facilities. Around 5% of the NTS cases give rise to invasive, extraintestinal diseases leading to focal infections like osteomyelitis, meningitis, osteoarthritis, endocarditis and neonatal sepsis. iNTS serovars like S. Typhimurium, S. Enteritidis, S. Dublin, S. Choleraesuis show a greater propensity to become invasive than others which hints at the geneti...
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Dipasree Hajra Abhilash Vijay Nair Dipshikha Chakravortty Source Type: research

Development of diphenylmethylpiperazine hybrids of chloroquinoline and triazolopyrimidine using Petasis reaction as new cysteine proteases inhibitors for malaria therapeutics
Eur J Med Chem. 2023 Jun 12;258:115564. doi: 10.1016/j.ejmech.2023.115564. Online ahead of print.ABSTRACTMalaria is a widespread infectious disease, causing nearly 247 million cases in 2021. The absence of a broadly effective vaccine and rapidly decreasing effectiveness of most of the currently used antimalarials are the major challenges to malaria eradication efforts. To design and develop novel antimalarials, we synthesized a series of 4,7-dichloroquinoline and methyltriazolopyrimidine analogues using a multi-component Petasis reaction. The synthesized molecules (11-31) were screened for in-vitro antimalarial activity ag...
Source: Cell Research - June 15, 2023 Category: Cytology Authors: Hari Madhav Tarosh S Patel Zeba Rizvi G Srinivas Reddy Abdur Rahman Md Ataur Rahman Saiema Ahmedi Sadaf Fatima Kanika Saxena Nikhat Manzoor Souvik Bhattacharjee Bharat C Dixit Puran Singh Sijwali Nasimul Hoda Source Type: research

Defining species-specific and conserved interactions of apical membrane protein 1 during erythrocyte invasion in malaria to inform multi-species vaccines
Cell Mol Life Sci. 2023 Feb 27;80(3):74. doi: 10.1007/s00018-023-04712-z.ABSTRACTPlasmodium falciparum and P. vivax are the major causes of human malaria, and P. knowlesi is an important additional cause in SE Asia. Binding of apical membrane antigen 1 (AMA1) to rhoptry neck protein 2 (RON2) was thought to be essential for merozoite invasion of erythrocytes by Plasmodium spp. Our findings reveal that P. falciparum and P. vivax have diverged and show species-specific binding of AMA1 to RON2, determined by a β-hairpin loop in RON2 and specific residues in AMA1 Loop1E. In contrast, cross-species binding of AMA1 to RON2 is re...
Source: Cellular and Molecular Life Sciences : CMLS - February 27, 2023 Category: Cytology Authors: Damien R Drew Danny W Wilson Gretchen E Weiss Lee M Yeoh Isabelle G Henshall Brendan S Crabb Sheetij Dutta Paul R Gilson James G Beeson Source Type: research

Genetic diversity and expression profile of Plasmodium falciparum Pf34 gene supports its immunogenicity
CONCLUSION: The limited genetic diversity, presence of conserved amino acid repeats within B cell epitope and high IgG response suggests that Pf34 may be a potential vaccine candidate for malaria. However, further validation studies are required.PMID:34425378 | DOI:10.1016/j.retram.2021.103308
Source: Cell Research - August 23, 2021 Category: Cytology Authors: Sri Krishna Sneha Bhandari Anup Kumar Vishwakarma Anil Kumar Verma Mrigendra P Singh Anjana Sharma Neeru Singh Praveen K Bharti Source Type: research