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ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells.
Abstract Satellite cells are resident stem cells of skeletal muscle, supplying myoblasts for postnatal muscle growth, hypertrophy and repair. Of the complex regulatory networks that control satellite cells, the EGF-family of ligands contributes. Here we investigated the role of ErbB3 binding protein-1 (Ebp1) in regulation of myogenic stem cell proliferation and differentiation. Ebp1 is a well-conserved DNA/RNA binding protein that is implicated in cell growth, apoptosis and differentiation in many cell types. Of the two main Ebp1 isoforms, only p48 was expressed in satellite cells and C2C12 myoblasts. While not pr...
Source: Developmental Biology - November 22, 2013 Category: Biology Authors: Figeac N, Serralbo O, Marcelle C, Zammit PS Tags: Dev Biol Source Type: research

The Human Constitutive Androstane Receptor Promotes the Differentiation and Maturation of Hepatic-like Cells.
Abstract Expression of the constitutive androstane receptor (CAR, NR1I3) is enriched in the mature mammalian liver and increasingly recognized for its prominent role in regulating a myriad of processes including biotransformation, chemical transport, energy metabolism and lipid homeostasis. Previously, we demonstrated that CAR levels were markedly enhanced during the differentiation of hepatic-like cells derived from hESCs, prompting the hypothesis that CAR contributes a key functional role in directing human hepatogenesis. Here we demonstrate that over-expression of CAR in human embryonic stem cells (ESCs), trans...
Source: Developmental Biology - October 18, 2013 Category: Biology Authors: Chen F, Zamule SM, Coslo DM, Chen T, Omiecinski CJ Tags: Dev Biol Source Type: research

Effects of Zinc Transporter on Differentiation of Bone Marrow Mesenchymal Stem Cells to Osteoblasts.
Abstract The differentiation of bone marrow mesenchymal stem cells (MSCs) into osteoblasts is a crucial step during bone formation. However, the exact mechanisms regulating the early stages of osteogenic differentiation remain unknown. In the present study, we found that ZnT7, a member of the zinc transporter family SLC30A(ZnTs), was downregulated during dexamethasone-induced differentiation of rat MSCs into osteoblasts. Dexamethasone treatment resulted in significantly lower levels of ZnT7 compared with cocultured cells without dexamethasone. Differentiation was evaluated by measuring alkaline phosphatase (ALP) a...
Source: Biological Trace Element Research - June 18, 2013 Category: Biology Authors: Liu Y, Yan F, Yang WL, Lu XF, Wang WB Tags: Biol Trace Elem Res Source Type: research

Pitx genes are redeployed in adult myogenesis where they can act to promote myogenic differentiation in muscle satellite cells.
Abstract Skeletal muscle retains a resident stem cell population called satellite cells. Although mitotically quiescent in mature muscle, satellite cells can be activated to produce myoblast progeny to generate myonuclei for skeletal muscle homoeostasis, hypertrophy and repair. Regulation of satellite cell function in adult requires redeployment of many of the regulatory networks fundamental to developmental myogenesis. Involved in such control of muscle stem cell fate in embryos are members of the Pitx gene family of bicoid-class homeodomain proteins. Here, we investigated the expression and function of all three...
Source: Developmental Biology - May 1, 2013 Category: Biology Authors: Knopp P, Figeac N, Fortier M, Moyle L, Zammit PS Tags: Dev Biol Source Type: research

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