Filtered By:
Specialty: Genetics & Stem Cells

This page shows you your search results in order of relevance. This is page number 12.

Order by Relevance | Date

Total 1523 results found since Jan 2013.

GSE80214 Genome-wide transcriptional profiling of Legionella Pneumophila-infected A549 cells transfected with siRNA against TNFAIP2
In this study we transfected A549 cells with siRNA against TNFAIP2, infected them with L. pneumophila and performed transcriptional profiling. We found enrichment of genes in pro-inflammatorypathways by Pathway Over-respresentation analysis upon infection. There was no significant change in gene expression that we could attribute specifically to the knockdown of TNFAIP2.
Source: GEO: Gene Expression Omnibus - April 13, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

siRNA Therapeutics for Primary Hyperoxaluria: A Beginning
Molecular Therapy 24, 666 (April 2016). doi:10.1038/mt.2016.50 Author: Dawn S Milliner
Source: Molecular Therapy - April 14, 2016 Category: Genetics & Stem Cells Authors: Dawn S Milliner Source Type: research

Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1
, Henryk Dudek, Eduardo Salido, Bob D Brown & Chengjung Lai
Source: Molecular Therapy - April 14, 2016 Category: Genetics & Stem Cells Authors: Chaitali DuttaNicole Avitahl-CurtisNatalie PursellMarita Larsson CohenBenjamin HolmesRohan DiwanjiWei ZhouLuciano ApponiMartin KoserBo YingDongyu ChenXue ShuiUtsav SaxenaWendy A CyrAnee ShahNaim NazefWeimin WangMarc AbramsHenryk DudekEduardo SalidoBob D B Source Type: research

Relationship Between the Physicochemical Properties of Lipid Nanoparticles and the Quality of siRNA Delivery to Liver Cells
Harashima
Source: Molecular Therapy - April 14, 2016 Category: Genetics & Stem Cells Authors: Yusuke SatoHiroto HatakeyamaMamoru HyodoHideyoshi Harashima Source Type: research

siRNA targeting the κ light chain constant region: preclinical testing of an approach to nonfibrillar and fibrillar light chain deposition diseases
siRNA targeting the κ light chain constant region: preclinical testing of an approach to nonfibrillar and fibrillar light chain deposition diseases Gene Therapy advance online publication, July 7 2016. doi:10.1038/gt.2016.50 Authors: X Ma, P Zhou, S W Wong, M Warner, C Chaulagain & R L Comenzo
Source: Gene Therapy - July 6, 2016 Category: Genetics & Stem Cells Authors: X MaP ZhouS W WongM WarnerC ChaulagainR L Comenzo Source Type: research

A Chromatin-Focused siRNA Screen for Regulators of p53-Dependent Transcription
The protein product of the Homo sapiens TP53 gene is a transcription factor (p53) that regulates the expression of genes critical for the response to DNA damage and tumor suppression, including genes involved in cell cycle arrest, apoptosis, DNA repair, metabolism, and a number of other tumorigenesis-related pathways. Differential transcriptional regulation of these genes is believed to alter the balance between two p53-dependent cell fates: cell cycle arrest or apoptosis. A number of previously identified p53 cofactors covalently modify and alter the function of both the p53 protein and histone proteins. Both gain- and lo...
Source: G3: Genes Genomes Genetics - August 8, 2016 Category: Genetics & Stem Cells Authors: Sammons, M. A., Zhu, J., Berger, S. L. Tags: Mutant Screen Report Source Type: research

GSE86924 Effect of NR4A3 siRNA treatment on gene expression of islet derived hybrid cell of 1.1B4
Contributors : Yuzuru Otsuka ; Motoko Yamada ; Etsuko UetaSeries Type : Expression profiling by arrayOrganism : Homo sapiensGene regulation associated with antioxidant defense system in pancreatic beta cells still needs to be elucidated, we found NR4A3 gene expression was up-regulated with 100mM H2O2, therefore, we analyzed the genes expression with Agilent micro-array after NR4A3 siRNA4 treatment by one color method, and found 1044 genes were up-regulated and 859 genes were down regulated in NR4A3 knocked down cell. Changes of some genes expressions were confirmed by real time PCR.The genes of 1044 in NR4A3 siRNA treated ...
Source: GEO: Gene Expression Omnibus - September 15, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Tackling breast cancer chemoresistance with nano-formulated siRNA
erkel
Source: Gene Therapy - October 19, 2016 Category: Genetics & Stem Cells Authors: S K Jones O M Merkel Source Type: research

Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing
mp; Anastasia Khvorova
Source: Molecular Therapy - November 6, 2016 Category: Genetics & Stem Cells Authors: Marie-C écile Didiot Lauren M Hall Andrew H Coles Reka A Haraszti Bruno MDC Godinho Kathryn Chase Ellen Sapp Socheata Ly Julia F Alterman Matthew R Hassler Dimas Echeverria Lakshmi Raj David V Morrissey Marian DiFiglia Neil Aronin Anastasia Khvorova Source Type: research

Remodeling of the Extracellular Matrix by Endothelial Cell-Targeting siRNA Improves the EPR-Based Delivery of 100  nm Particles
Remodeling of the Extracellular Matrix by Endothelial Cell-Targeting siRNA Improves the EPR-Based Delivery of 100 nm Particles Molecular Therapy 24, 2090 (December 2016). doi:10.1038/mt.2016.178 Authors: Yu Sakurai, Tomoya Hada, Shoshiro Yamamoto, Akari Kato, Wataru Mizumura & Hideyoshi Harashima
Source: Molecular Therapy - December 13, 2016 Category: Genetics & Stem Cells Authors: Yu Sakurai Tomoya Hada Shoshiro Yamamoto Akari Kato Wataru Mizumura Hideyoshi Harashima Source Type: research

The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA
r R Cullis
Source: Molecular Therapy - December 13, 2016 Category: Genetics & Stem Cells Authors: Haitang Wang Yuen Yi C Tam Sam Chen Josh Zaifman Roy van der Meel Marco A Ciufolini Pieter R Cullis Source Type: research

GSE91484 siRNA RNA-seq from K562 (ENCSR100ODO)
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA-seq on K562 cells treated with siRNA targeting NFE2L2.For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf
Source: GEO: Gene Expression Omnibus - January 3, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE91435 siRNA RNA-seq from K562 (ENCSR047MQO)
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA-seq on K562 cells treated with siRNA targeting VEZF1.For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf
Source: GEO: Gene Expression Omnibus - January 3, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Genetic pharmacology: progresses in siRNA delivery and therapeutic applications
Escriou
Source: Gene Therapy - February 15, 2017 Category: Genetics & Stem Cells Authors: D Scherman A Rousseau P Bigey V Escriou Source Type: research