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Clinicopathologic Profiles of Sporadic Late-Onset Nemaline Myopathy: Practical Importance of Anti-{alpha}-Actinin Immunostaining
Discussion SLONM is a treatable myopathy with ASCT or traditional immunotherapy, especially when combined with steroids and immunosuppressants. Anti–α-actinin immunostaining is the most reliable pathologic marker to identify rod-bearing fibers, and it should be performed routinely in adult patients with undiagnosed nonnecrotic myopathies.
Source: Neurology Neuroimmunology and Neuroinflammation - May 17, 2022 Category: Neurology Authors: Zhao, B., Dai, T., Zhao, D., Ma, X., Zhao, C., Li, L., Sun, Y., Zhang, Y., Yan, Y., Lu, J.-Q., Liu, F., Yan, C. Tags: MRI, All Immunology, Autoimmune diseases, All Clinical Neurology, Muscle disease Research Article Source Type: research

Case Report: Calpainopathy Presenting After Bone Marrow Transplantation, With Studies of Donor Genetic Content in Various Tissue Types
This report emphasizes that genetic disease should still be considered in the context of presumably acquired disease, and also demonstrates the extent of transdifferentiation of donor cells into other tissues.
Source: Frontiers in Neurology - January 11, 2021 Category: Neurology Source Type: research

Chemotherapy with stem cell transplantation is more effective than immunotherapy in sporadic late onset nemaline myopathy with monoclonal gammopathy
Chemotherapy with stem cell transplantation is more effective than immunotherapy in sporadic late onset nemaline myopathy with monoclonal gammopathy, Published online: 24 January 2018; doi:10.1038/s41409-017-0080-6Chemotherapy with stem cell transplantation is more effective than immunotherapy in sporadic late onset nemaline myopathy with monoclonal gammopathy
Source: Bone Marrow Transplantation - January 24, 2018 Category: Hematology Authors: Rouslan Kotchetkov Anna Dyszkiewicz-Korpanty Vishal Kukreti Source Type: research

Cyclophosphamide, thalidomide, and dexamethasone as alternative treatment regimen for sporadic late onset nemaline myopathy associated with monoclonal gammopathy of undetermined significance
We report a case of 33-year-old man with a 5-month history of proximal muscle weakness who later develop neck weakness and require tracheostomy.
Source: Neuromuscular Disorders - September 10, 2017 Category: Neurology Authors: J. Tanboon, T. Kumutpongpanich, W. Owattanapanich, T. Sangruchi, K. Boonyapisit, I. Nishino Source Type: research

CNS Toxoplasmosis: A Serious Complication Of Immunotherapy In The Neuromuscular Patient (P6.102)
Conclusions: Immunotherapy with medication such as MM can cause a devastating CNS toxoplasmosis in non-HIV patients with neuromuscular disorders. In contrast to the HIV infected patients, treatment is ineffective implying a different pathogenesis. Early consideration and recognition of this complication is important to possibly prevent unfavorable outcome.Disclosure: Dr. Bernardo has nothing to disclose. Dr. Chahin has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Bernardo, D., Chahin, N. Tags: Neuromuscular Disease Source Type: research