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Transplantation Trends in End Stage Hypertrophic Cardiomyopathy Over 35 Years: A UNOS Registry Analysis
Hypertrophic cardiomyopathy (HCM) is a rare but potentially life-threatening form of hereditary myopathy with increasing incidence. Therapies are emerging for HCM but the incidence of end-stage HCM has been increasing. We sought to describe the incidence and outcomes of HCM transplantation over the last 35 years.
Source: The Journal of Heart and Lung Transplantation - April 1, 2023 Category: Transplant Surgery Authors: D.J. Miklin, E. DePasquale Tags: (527) Source Type: research

Heart transplantation for COVID-19 myopathy in the United States
Evidence on characteristics and outcomes of patients undergoing heart transplantation for coronavirus disease 2019 (COVID-19) associated cardiomyopathy is limited to case reports. Of all 6332 patients aged ≥18 years undergoing heart transplant from July 2020 through May 2022 in the United Network for Organ Sharing database, 12 (0.2%) patients had COVID-19 myocarditis and 98 (1.6%) patients with the same level of care had non-COVID-19 myocarditis. Their median age was 49 (range 19-74) years. All pati ents were hospitalized in the intensive care unit and 92.7% (n=102) were on life support prior to transplantation.
Source: The Journal of Heart and Lung Transplantation - October 5, 2022 Category: Transplant Surgery Authors: George Gill, Amy Roach, Georgina Rowe, Dominic Emerson, Jon Kobashigawa, Errol P. Lobo, Fardad Esmailian, Michael E. Bowdish, Joanna Chikwe Tags: Brief Communication Source Type: research

Major Adverse Dystrophinopathy Event Score as Marker of Cumulative Morbidity and Risk for Mortality in Boys with Duchenne Muscular Dystrophy
Accurate assessments of heart failure (HF) severity in Duchenne Muscular Dystrophy (DMD) is challenging due to overlapping symptoms from cardiomyopathy, respiratory insufficiency, and skeletal myopathy. We developed an ordinal scale of multiorgan clinical variables and events graded for severity that reflect cumulative disease burden-the Major Adverse Dystrophinopathy Event (MADE) score. We hypothesized that a higher MADE score would be associated with increased mortality in DMD. We used the CINRG Duchenne Natural History Study (DNHS) dataset for MADE score validation.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: B.D. Kaufman, A. Garcia, Z. He, M. Buu, C. Tesi-Rocha, J.W. Day, D.N. Rosenthal, H. Gordish-Dressman, C. Almond, T. Duong Tags: (200) Source Type: research

Successful Heart Transplantation in a Patient with Neonatal Marfan Syndrome
We describe a case of a teenage girl with NMS who developed inotrope-dependent heart failure secondary to dilated cardiomyopathy requiring heart transplantation.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: S. Hussain, G. Geddes, R. Darragh, J.J. Parent Tags: (1285) Source Type: research

A Comparison of Short-Term Morbidity and Mortality Among Inpatient Lung Transplant Recipients Transplanted for COVID-19 and Other Restrictive Lung Diseases
Patients with respiratory failure (RF) who are hospitalized at the time of lung transplant (LTx) have higher post-LTx morbidity and mortality than those who are well enough to remain at home. Complications may be even worse in patients transplanted for COVID-19 (C19), as they are commonly critically ill having endured prolonged mechanical ventilation, ECMO support, myopathy, malnutrition, and superimposed infections. In a retrospective cohort study, we compared inpatient lung transplant recipients (LTxRs) transplanted for C19 vs.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: D. Razia, M.T. Olson, R. Walia, R.M. Bremner, M.A. Smith, S. Tokman Tags: (289) Source Type: research

Concomitant Mitochondrial Diabetes and Myopathy Mistook for Complications of Immunosuppressants After Kidney Transplant
We report the case of a 48-year-old woman with diabetes mellitus, sensorineural hearing loss, and severe myopathy without neuropathy after deceased donor kidney transplant. ShehadamitochondrialDNApointmutation at position 3243 (A>G), and mitochondrial diseases such as maternally inherited diabetes deafness or mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodeswere suspected.Diabetes andother symptoms following kidney transplant can often be overlooked as complications of immunosuppressants taken after kidney transplant. However, in patients without a known cause of their symptoms, appropriate exam...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - July 30, 2021 Category: Transplant Surgery Authors: Yong Hoon Shin Ae Jin Kim Han Ro Jae Hyun Chang Ji Yong Jung Woo Kyung Chung Hyun Hee Lee Source Type: research

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