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Antibiotic-Induced Disruption of Gut Microbiota Alters Local Metabolomes and Immune Responses
In conclusion, our study indicated that 3 weeks antibiotic administration induced elevated expression of many cytokines in mouse colon, suggesting that there might be a direct interaction between antibiotics and host tissue. Furthermore, different antibiotics used can lead to different effects on mouse models. Broad spectrum antibiotic enrofloxacin had a stronger effect on the cytokines response in the colon. Vancomycin can induce significant changes in composition and metabolic profiling of gut microbiota. Compared to enrofloxacin and vancomycin, polymixin B sulfate had a weakest effect. The differences observed in compos...
Source: Frontiers in cellular and infection microbiology - April 23, 2019 Category: Microbiology Source Type: research