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Long-term seroprotection after an adolescent booster meningococcal serogroup C vaccination
Conclusions The planned introduction in the UK of an adolescent booster of MenC conjugate vaccine in 2013 is likely to provide sustained protection against MenC disease. Trial registration Registered on ClinicalTrials.gov (NCT01459432).
Source: Archives of Disease in Childhood - August 13, 2013 Category: Pediatrics Authors: de Whalley, P. C. S., Snape, M. D., Plested, E., Thompson, B., Nuthall, E., Omar, O., Borrow, R., Pollard, A. J. Tags: Epidemiologic studies, Immunology (including allergy), Drugs: infectious diseases, Vaccination / immunisation, Adolescent health, Child health Original article Source Type: research

News Beyond Our Pages
The 7-valent pneumococcal vaccine (PCV7) was introduced into the US infant immunization schedule in 2000. Early observations noted a significant reduction in the incidence of invasive pneumococcal disease in all age groups, including unvaccinated persons, because of indirect or “herd” protection. There was also an early reduction in pneumonia hospitalizations in young children and among some adults. However, there was an increase in pneumococcal disease caused by serotypes not included in the vaccine. With concern that “serotype replacement” might have weakened gains made by PCV7 introduction, Griffin et al (N Engl...
Source: Journal of Allergy and Clinical Immunology - August 29, 2013 Category: Allergy & Immunology Authors: Marc E. Rothenberg, Jean Bousquet, Patricia C. Fulkerson Tags: News beyond our pages Source Type: research

Neurological manifestations of influenza infection in adults and children: results of a national british surveillance study
Conclusion This paediatric and adult UK cohort identified a severity of influenza related neurological manifestation not reported previously. Cases were more common in children, particularly those with underlying neurological conditions. Encephalopathy syndromes such as ANE, AIEF, HSE and AHL were seen more frequently in children and were associated with a worse outcome. Acute movement disorders and Guillain–Barré syndrome were identified more commonly in adults. Influenza related encephalopathy may be more common in those with abnormal genetically determined host inflammatory responses, but the virus itself i...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Goenka, A., Michael, B., Ledger, E., Hart, I., Absoud, M., Chow, G., Lilleker, J., Lim, M., Lunn, M., Peake, D., Pysden, K., Roberts, M., Carrol, E., Avula, S., Solomon, T., Kneen, R. Tags: Immunology (including allergy), Meningitis, Infection (neurology), Radiology, Adult intensive care, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Kinetics of the long-term antibody response after meningococcal C vaccination in patients with juvenile idiopathic arthritis: a retrospective cohort study
Conclusions Persistence of MenC-specific IgG antibodies in JIA patients is similar to healthy controls, but treatment with biologicals may induce accelerated antibody waning, resulting in unprotected patients who may need revaccination.
Source: Annals of the Rheumatic Diseases - February 27, 2014 Category: Rheumatology Authors: Stoof, S. P., Heijstek, M. W., Sijssens, K. M., van der Klis, F., Sanders, E. A. M., Teunis, P. F. M., Wulffraat, N. M., Berbers, G. A. M. Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology Clinical and epidemiological research Source Type: research

ANH-Intl News Alerts
The HPV vaccine, food labelling, muscle mass related to lower risk of death, the mumps vaccine, GM pollen in honey, meningitis vaccine, and the ASA
Source: Alliance for Natural Health - March 26, 2014 Category: Complementary Medicine Authors: Sophie Tags: allergy Alyssa Burns-Hill Alyssa Spills All ASA BMI europe food labelling FSA GM honey pollen HPV international meningitis mumps muscle mass NHS Jermey hunt research Source Type: news

Fifteen-minute consultation: Bacillus Calmette-Guerin abscess and lymphadenitis
Bacillus Calmette–Guérin (BCG) vaccine contains a live attenuated strain of Mycobacterium bovis, which provides 64% efficacy against tuberculous meningitis and 78% efficacy against disseminated tuberculosis.1 A number of local adverse reactions are recognised (abscess, suppurative lymphadentitis, keloid formation). An increased number of local complications were reported in the UK and Ireland since the introduction of a new BCG strain in 2002.2 3 It is important to distinguish between a normal vaccine response, a local complication and the very rare cases of systemic BCG infection that occur with immunodeficie...
Source: Archives of Disease in Childhood - Education and Practice - May 14, 2014 Category: Pediatrics Authors: Riordan, A., Cole, T., Broomfield, C. Tags: Epidemiologic studies, Immunology (including allergy), Drugs: infectious diseases, HIV/AIDS, Meningitis, Vaccination / immunisation, Infection (neurology), Pregnancy, Reproductive medicine, Child health, Infant health, Rheumatology, Sexual health, Dermato Source Type: research

Pneumococcal Vaccine Protects More Than Just Kids Who Get ItPneumococcal Vaccine Protects More Than Just Kids Who Get It
Since the introduction of PCV13, a 13-valent pediatric vaccine, the number of cases of invasive pneumococcal disease has declined, as has the antibiotic resistance of vaccine strains. Medscape Medical News
Source: Medscape Allergy Headlines - October 14, 2014 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

Improving the care of children and young people in the UK: 20 years on
Introduction In 2000, practitioners in child health asked a simple question—who speaks for children and their health at the policy level?1 It documented the invisibility of children in the National Health Service (NHS) and made recommendations for the future. As we experience unprecedented political turbulence, austerity, increasing poverty and ideological reforms of health and education, is all well in the UK for children, childhood and child health now? The context Children are our nation's most precious resource because of the change in the old age dependency ratio—the number of active working age adults per...
Source: Archives of Disease in Childhood - December 15, 2014 Category: Pediatrics Authors: Aynsley-Green, A. Tags: Immunology (including allergy), Meningitis, TB and other respiratory infections, Tropical medicine (infectious diseases), Vaccination / immunisation, Infection (neurology), Neuromuscular disease, Pain (neurology), Adolescent health, Child health, Pain (pa Source Type: research

Pneumococcal conjugate vaccines PREVenar13 and SynflorIX in sequence or alone in high-risk Indigenous infants (PREV-IX_COMBO): protocol of a randomised controlled trial
Introduction Otitis media (OM) starts within weeks of birth in almost all Indigenous infants living in remote areas of the Northern Territory (NT). OM and associated hearing loss persist from infancy throughout childhood and often into adulthood. Educational and social opportunities are greatly compromised. Pneumococcus and non-typeable Haemophilus influenzae (NTHi) are major OM pathogens that densely colonise the nasopharynx and infect the middle ear from very early in life. Our hypothesis is that compared to current single vaccine schedules, a combination of vaccines starting at 1 month of age, may provide earlier, ...
Source: BMJ Open - January 16, 2015 Category: Journals (General) Authors: Leach, A. J., Mulholland, E. K., Santosham, M., Torzillo, P. J., Brown, N. J., McIntyre, P., Smith-Vaughan, H., Skull, S., Balloch, A., Andrews, R., Carapetis, J., McDonnell, J., Krause, V., Morris, P. S., Grierson, Wilson, Birt, Hayes, Wienert, Nankervis Tags: Open access, Ear, nose and throat/otolaryngology, Immunology (including allergy), Infectious diseases, Paediatrics Protocol Source Type: research

Has the incidence of empyema in Scottish children continued to increase beyond 2005?
Conclusions The incidence of empyema in Scottish children initially rose in children aged 1 to 9 years after the introduction of routine conjugate pneumococcal vaccination, however, empyema incidence has fallen since 2010 when the PCV-13 was introduced.
Source: Archives of Disease in Childhood - February 18, 2015 Category: Pediatrics Authors: Nath, S., Thomas, M., Spencer, D., Turner, S. Tags: Immunology (including allergy), Drugs: infectious diseases, Pneumonia (infectious disease), TB and other respiratory infections, Vaccination / immunisation, Pneumonia (respiratory medicine), Ear, nose and throat/otolaryngology Original article Source Type: research

Humoral immune response to vaccines in patients with rheumatoid arthritis treated with tocilizumab: results of a randomised controlled trial (VISARA)
Conclusions Short-term TCZ treatment does not significantly attenuate humoral responses to PPV23 or TTV. To maximise vaccine response, patients should be up to date with immunisations before starting TCZ treatment. ClinicalTrials.gov identifier NCT01163747.
Source: Annals of the Rheumatic Diseases - April 2, 2015 Category: Rheumatology Authors: Bingham, C. O., Rizzo, W., Kivitz, A., Hassanali, A., Upmanyu, R., Klearman, M. Tags: Open access, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology Clinical and epidemiological research Source Type: research

Using root cause analysis (rca) to ensure learning from an error involving the national infant primary immunisation schedule
Conclusion Using RCA methodology to investigate this error identified several deficiencies in the process for immunisation within our Trust enabling action to be taken to ensure that the process is more robust in the future. This has included changing pharmacy purchasing processes for immunisations, identifying both a lead pharmacist and clinician for immunisations, improving links with primary care and PHE and starting to develop minimum standards for immunisations within the Trust. Involving PHE in the RCA process also facilitated learning on a national basis.
Source: Archives of Disease in Childhood - May 18, 2015 Category: Pediatrics Authors: Aindow, A., Gill, A., Sharpe, D., Barker, C., Mulvoy, J., Falconer, M., Riordan, A. Tags: Immunology (including allergy), Drugs: infectious diseases, Vaccination / immunisation, Child health, Infant health Short Papers Source Type: research

Vaccine evaluation: lessons from a meningococcal B vaccine
Vaccination is among the most effective public health interventions of the past century, with immunisations against some of the most common and devastating childhood infections already in use to great effect. The development of new vaccines depends on advances in the field of vaccinology that carry high monetary costs. In most countries, these costs pose an obstacle to adoption of new vaccines. To that end, together with the scientific evaluation of new vaccines, an economic evaluation is vital. This aims to determine whether investment in the proposed vaccine is worthwhile. In this article, we will examine one such case s...
Source: Archives of Disease in Childhood - May 18, 2015 Category: Pediatrics Authors: Sarfatti, A., Martinon-Torres, F., Nadel, S. Tags: Patients, Health policy, Vaccination programs, Immunology (including allergy), Drugs: infectious diseases, Meningitis, Vaccination / immunisation, Infection (neurology), Neonatal and paediatric intensive care, Paediatric intensive care, Health economics, Source Type: research

ACIP backs broader use of MenB vaccination to include adolescents and college students
A recommendation to expand serogroup B meningococcal vaccination to include adolescents and young adults, including college students, was supported by the Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices, at a <a...
Source: Skin and Allergy News - June 24, 2015 Category: Dermatology Tags: CNN News CNN Pediatric Neurology EM Clinical News EM News EM Infectious Disease FPN News FPN Child & Adolescent Medicine FPN Infectious Diseases Source Type: news

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