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Specialty: Drugs & Pharmacology

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Total 2046 results found since Jan 2013.

Traditional Chinese medicine and drug-induced anaphylaxis: data from the Beijing pharmacovigilance database
Conclusion TCM was associated with a decreased risk of DIA compared to non-TCM drugs in drug allergy cases, and the risk was higher for TCM injections.
Source: International Journal of Clinical Pharmacy - July 26, 2018 Category: Drugs & Pharmacology Source Type: research

Hepatic cytochrome P450 metabolism suppressed by mast cells in type 1 allergic mice.
Abstract Mast cells and Kupffer cells secrete interleukin (IL)-1β, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α, which stimulate excess nitric oxide (NO) producing-inducible NO synthase (iNOS). Unlike Kupffer cells, immunoglobulin E-sensitized mast cells elicit sustained NO production. We investigated the participation of mast cell-released NO and cytokine-derived iNOS activation in type 1 allergy-suppressed hepatic cytochrome P450 (CYP) metabolism. Aminoguanidine, a selective iNOS inhibitor, completely suppressed serum nitrate plus nitrite (NOx) concentrations after primary and secondary sensitization...
Source: Biochemical Pharmacology - November 2, 2018 Category: Drugs & Pharmacology Authors: Tanino T, Bando T, Nojiri Y, Okada Y, Nagai N, Ueda Y, Sakurai E Tags: Biochem Pharmacol Source Type: research

Impact of a multidisciplinary workflow on safety and management of patients with heparin-induced thrombocytopenia.
CONCLUSION: Implementation of a multidisciplinary workflow for the management of HIT significantly reduced the incidence of heparin administration while testing was ongoing and improved the rate of appropriate heparin allergy documentation. PMID: 33103184 [PubMed - as supplied by publisher]
Source: American Journal of Health-System Pharmacy : AJHP - October 26, 2020 Category: Drugs & Pharmacology Authors: Northam KA, Chen SL, Stivers AP, Cicci JD, Hedrick TL, Rollins-Raval MA, Kasthuri RS Tags: Am J Health Syst Pharm Source Type: research

Isoflavones Suppress Cyp26b1 Expression in the Murine Colonic Lamina Propria.
In this study, we evaluated the effects of various isoflavones on Cyp26b1 expression in primary cultured lamina propria (LP) cells isolated from the mouse colon. The mRNA expression of Cyp26b1 was extremely downregulated by all isoflavones tested in the LP cells except for puerarin. In particular, genistein and genistin markedly suppressed Cyp26b1 mRNA expression without affecting RA-synthesizing enzyme expression. Moreover, to evaluate the effects of isoflavones on allergic reactions, genistein and genistin were administered to ovalbumin (OVA)-induced food allergy mice. Oral administration of genistin suppressed the devel...
Source: Biological and Pharmaceutical Bulletin - December 4, 2020 Category: Drugs & Pharmacology Authors: Yamamoto T, Nagata Y, Hayashi S, Kadowaki M Tags: Biol Pharm Bull Source Type: research

Methods for Detecting Pediatric Adverse Drug Reactions from the Electronic Medical Record
This article is protected by copyright. All rights reserved.PMID:34031886 | DOI:10.1002/jcph.1916
Source: The Journal of Clinical Pharmacology - May 25, 2021 Category: Drugs & Pharmacology Authors: Lydia M Joyner Leah A Alicea Jennifer L Goldman Sarah L Suppes Emma M Tillman Source Type: research