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Specialty: Respiratory Medicine
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Total 4701 results found since Jan 2013.
Allergy Season Springs Into Bloom
Allergist outlines ways to minimize effects of pollen
Source: Pulmonary Medicine News - Doctors Lounge - March 22, 2014 Category: Respiratory Medicine Authors: webmaster at doctorslounge.com Tags: Family Medicine, Pulmonology, Asthma, Allergy, Preventive Medicine, News, Source Type: news
Guidance on handheld inhalers in asthma and COPD guidelines
Summary: Background: Inhaled therapy is the cornerstone of pharmacotherapy in patients with asthma and chronic obstructive pulmonary disease (COPD). Appropriate inhalation device selection is as important as drug choice but device-specific guidance appears to be lacking.Methods: To quantify the level of inhalation-device recommendations in clinical guidelines, a review was conducted by hand-searching national and international asthma and COPD guidelines (Global Initiative for Asthma [GINA] and Global initiative for chronic Obstructive Lung Disease [GOLD] guidelines) and an international guideline on device selection (the A...
Source: Respiratory Medicine CME - March 3, 2014 Category: Respiratory Medicine Authors: P.N. Richard Dekhuijzen, Leif Bjermer, Federico Lavorini, Vincent Ninane, Mathieu Molimard, John Haughney Tags: Asthma and Allergy Source Type: research
FDA Panel Says No to Over-the-Counter Allergy Drug Singulair
Experts expressed relief at the decision, citing safety concerns
Source: Pulmonary Medicine News - Doctors Lounge - May 3, 2014 Category: Respiratory Medicine Authors: webmaster at doctorslounge.com Tags: Pharmacy, Pulmonology, Asthma, Allergy, News, Source Type: news
Maternal stress during pregnancy increases neonatal allergy susceptibility: Role of glucocorticoids
We sought to test experimentally whether maternal stress can promote susceptibility to development of asthma-like allergic airways disease in offspring. Normal pregnant mice (day 15) were subjected to a single restraint stress exposure. We subsequently tested their offspring for the development of airway hyperreactivity (AHR) and allergic airway inflammation (AI), after an intentionally suboptimal sensitization protocol. The offspring of stressed mothers showed levels of AI and enhanced airway responses to methacholine comparable to those seen in fully sensitized and challenged positive control animals; in contrast, minima...
Source: AJP: Lung Cellular and Molecular Physiology - July 15, 2014 Category: Respiratory Medicine Authors: Lim, R., Fedulov, A. V., Kobzik, L. Tags: ARTICLES Source Type: research
Predictors of work-related sensitisation, allergic rhinitis and asthma in early work life
Although work-related asthma and allergies are a huge burden for society, investigation of occupational exposures in early work life using an unexposed reference group is rare. Thus, the present analyses aimed to assess the potential impact of occupational exposure and other risk factors on the prevalence of work-related sensitisation and incidence of allergic rhinitis/asthma using a population-based approach and taking into account an unexposed reference group.
In SOLAR (Study on Occupational Allergy Risks) II, German participants of ISAAC (International Study of Asthma and Allergies in Childhood) phase II were followed f...
Source: European Respiratory Journal - August 31, 2014 Category: Respiratory Medicine Authors: Kellberger, J., Peters-Weist, A. S., Heinrich, S., Pfeiffer, S., Vogelberg, C., Roller, D., Genuneit, J., Weinmayr, G., von Mutius, E., Heumann, C., Nowak, D., Radon, K. Tags: Epidemiology, occupational and environmental lung disease, Asthma and allergy Original Articles: Asthma Source Type: research
Current evidence of epidermal barrier dysfunction and thymic stromal lymphopoietin in the atopic march
It has long been observed that the development of asthma, allergic rhinitis and food allergy are frequently preceded by atopic dermatitis, a phenomenon known as the "atopic march". Clinical, genetic and experimental studies have supported the fact that atopic dermatitis could be the initial step of the atopic march, leading to the subsequent development of other atopic diseases. This brief review will focus on the current evidence showing that epidermal barrier dysfunction and the keratinocyte-derived cytokine thymic stromal lymphopoietin play critical roles in the onset of the atopic march.
Source: European Respiratory Review - August 31, 2014 Category: Respiratory Medicine Authors: Li, M. Tags: Asthma and allergy, Lung biology and experimental studies, Mechanisms of lung disease Mini-Reviews Source Type: research
Mast cells in human airways: the culprit?
By virtue of their undisputed role in allergy, the study of airway mast cells has focused on nasal and bronchial mast cells and their involvement in allergic rhinitis and asthma. However, recent mechanistic and human studies suggest that peripheral mast cells also have an important role in asthma, as well as chronic obstructive pulmonary disease, respiratory infections and lung fibrosis. Pathogenic roles include immune-modulatory, pro-inflammatory and pro-fibrotic activities. Importantly, mast cells also actively downregulate inflammation and participate in the defence against respiratory infections. Another complicating f...
Source: European Respiratory Review - August 31, 2014 Category: Respiratory Medicine Authors: Erjefalt, J. S. Tags: Asthma and allergy, Mechanisms of lung disease Mini-Reviews Source Type: research
Regulatory T cells in children with allergy and asthma: It is time to act
Publication date: Available online 18 November 2014 Source:Respiratory Physiology & Neurobiology Author(s): Anna Stelmaszczyk-Emmel Nowadays allergy and asthma are a huge medical problem. Despite deeper and more precise knowledge concerning their pathogenesis and the role of the immune system in these processes, so far immunotherapy is the only treatment which can modify the course of these diseases. Considering that regulatory T cells (Treg cells) have a great significance in pathogenesis of both diseases it seems appropriate to pay attention to their role in the treatment process. This work summarizes the Treg ...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research
Epidemiology and characteristics of severe asthma exacerbations in children
Conclusion:The overall SAE rate was 0.02/PY, being highest in children <7 and >15 years and in treated children. Seasonal patterns were observed. Factors associated with frequent SAE are age, previous SAE and pediatrician consults.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Engelkes, M., Janssens, H., de Ridder, M., Sturkenboom, M., de Jongste, J., Verhamme, K. Tags: 7.2 Paediatric Asthma and Allergy Source Type: research
Late-breaking abstract: The certification of allergy-, asthma- and COPD-clinics in primary care in Southern Sweden
ConclusionBy certifying asthma and COPD clinics both the education level and the allocated time for patients can beincreased.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Lagorstrand, B., Bjermer, L., Karegard, M., Tunsater, A., Romberg, K. Tags: 1.6 General Practice and Primary Care Source Type: research
LSC 2014 abstract - Chemerin/ChemR23 pathway in diesel exhaust particles-induced pulmonary inflammation
Conclusions: These data suggest that the chemerin/ChemR23 axis is involved in the DEP-induced monocyte-derived DC recruitment.Funding: FWO Vlaanderen; Belgian IUAP P7/30; Concerted Research Initiative – Ghent University.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Provoost, S., De Grove, K., Fraser, G., Tournoy, K., Brusselle, G., Maes, T., Joos, G. Tags: 5.3 Allergy and Immunology Source Type: research
Sensitization to three mites in Cuban children with allergic respiratory diseases
Conclusions: There are one strong relation between allergic respiratory diseases and sensitization to mites in Cuban children.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Alvarez, M., Castro, R., Labrada, A., Enriquez, I., Ronquillo, M., Rodriguez, J. Tags: 7.2 Paediatric Asthma and Allergy Source Type: research
Regional differences in sensitization to Ambrosia in Croatian children
Conclusions: Region of Slavonia measures highest Ambrosia pollen concentrations and also most de novo sensitized children, which leads to assumption that sensitization rates are primary correlated to exposure levels to Ambrosia pollen.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Banic, I., Vecenaj, A., Miletic Gospic, A., Perica, M., Zivkovic, J., Plavec, D., Cvitkovic, A., Peternel, R., Peris, N., Turkalj, M. Tags: 7.2 Paediatric Asthma and Allergy Source Type: research
Late-breaking abstract: Surfactant protein D is dysregulated in severe asthma
Conclusions: BAL SP-D leakage into the serum in severe asthmatics might provide a peripheral blood biomarker reflecting increased epithelial damage and/or epithelial permeability within the airways.In addition these findings reveal impaired innate immunity within the airways in severe asthma.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Mackay, R.-M., Grainge, C., Lau, L., Barber, C., Clark, H., Howarth, P. Tags: 5.3 Allergy and Immunology Source Type: research
Late-breaking abstract: IL-5-induced airways eosinophilia as a negative regulator of TLR7 expression may impair the interferon response to rhinovirus in allergic airways
Conclusions: This implicates IL-5-induced airways eosinophilia as a negative regulator of TLR7 expression.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Collison, A., Hatchwell, L., Girkin, J., Parsons, K., Li, J., Zhang, J., Phipps, S., Knight, D., Bartlett, N. W., Johnston, S. L., Foster, P. S., Wark, P. A. B., Mattes, J. Tags: 5.3 Allergy and Immunology Source Type: research
