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Nutrition: Herbs

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Total 19 results found since Jan 2013.

Oxymatrine attenuates oxidized low ‑density lipoprotein‑induced HUVEC injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway
Int J Mol Med. 2021 Oct;48(4):187. doi: 10.3892/ijmm.2021.5020. Epub 2021 Aug 9.ABSTRACTOxymatrine, a quinolizidine alkaloid isolated from the traditional Chinese herb Sophora flavescens Aiton, has been demonstrated to exert anti‑inflammatory and atherosclerotic effects, but the molecular mechanism has yet to be elucidated. Accumulating evidence indicates an important role of NLR family pyrin domain containing 3 (NLRP3) inflammasome‑mediated pyroptosis in the pathogenesis of atherosclerosis. The present study was undertaken to investigate whether oxymatrine attenuates oxidized low‑density lipoprotein (ox‑LDL)‑ind...
Source: International Journal of Molecular Medicine - August 9, 2021 Category: Molecular Biology Authors: Xin Jin Wan Fu Jiaxiu Zhou Niannian Shuai Yan Yang Bo Wang Source Type: research

Salidroside reduces cold-induced mucin production by inhibiting TRPM8 activation.
Abstract Salidroside is an effective component of the traditional Chinese herb, Rhodiola rosea, that is known to have the ability to protect individuals from cold attacks. In the present study, we investigated the effects of salidroside on respiratory epithelial cells exposed to cold temperatures. We wished to determine whether salidroside exerts any effect on cold-induced mucin (MUC) production and the possible mechanisms involved in this process. We incubated HBE16 cells with salidroside, exposed them to a cold stimulus (18˚C), and assayed the following endpoints: MUC production (the expression of MUC5AC), conc...
Source: International Journal of Molecular Medicine - July 5, 2013 Category: Molecular Biology Authors: Li Q, Zhou XD, Kolosov VP, Perelman JM Tags: Int J Mol Med Source Type: research

Purified vitexin compound 1 inhibits growth and angiogenesis through activation of FOXO3a by inactivation of Akt in hepatocellular carcinoma.
Abstract Vitexins, isolated from the seeds of the Chinese herb Vitex negundo, is known to exert antitumor activity in cancer xenograft models and cell lines. The aim of the current study was to examine whether the Akt/forkhead box protein O3a (FOXO3a) pathway mediates the biological effects of purified vitexin compound 1 (VB-1) in hepatocellular carcinoma (HCC) cells. The effect of VB-1 on the viability of the HCC cell lines HepG2, Hep3B, Huh-7 and the human embryonic liver cells L-02 was investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Growth inhibition was assess...
Source: International Journal of Molecular Medicine - December 12, 2013 Category: Molecular Biology Authors: Wang J, Zheng X, Zeng G, Zhou Y, Yuan H Tags: Int J Mol Med Source Type: research

SH003 selectively induces p73 ‑dependent apoptosis in triple‑negative breast cancer cells.
SH003 selectively induces p73‑dependent apoptosis in triple‑negative breast cancer cells. Mol Med Rep. 2016 Sep 6; Authors: Choi EK, Kim SM, Hong SW, Moon JH, Shin JS, Kim JH, Hwang IY, Jung SA, Lee DH, Lee EY, Lee S, Kim H, Kim D, Kim YS, Choi YK, Kim HI, Choi HS, Cho SG, Kim JE, Kim KP, Hong YS, Lee WK, Lee JS, Kim TW, Ko SG, Jin DH Abstract Triple-negative breast cancer (TNBC) is a breast cancer subtype that has an aggressive phenotype, is highly metastatic, has limited treatment options and is associated with a poor prognosis. In addition, metastatic TNBC has no preferred standard chemotherapy ...
Source: Molecular Medicine Reports - September 10, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal
In conclusion, baicalin and scutellarin, though structurally similar, promoted glucose disposal in adipocytes by differential regulation on AMPK and Akt activity. Our data provide insight that multicomponent herbal medicines may act synergistically and cooperatively on multiple targets. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - November 26, 2016 Category: Molecular Biology Source Type: research

β‐Caryophyllene oxide Inhibits Constitutive and Inducible STAT3 Signaling Pathway Through Induction of the SHP‐1 Protein Tyrosine Phosphatase
Abstract Constitutive activation of STAT3 is frequently observed and closely linked with proliferation, survival, invasion, metastasis and angiogenesis in tumor cells. In the present study, we investigated whether β‐caryophyllene oxide (CPO), a sesquiterpene isolated primarily from the essential oils of medicinal plants such as guava (Psidium guajava), and oregano (Origanum vulgare L.), can mediate its effect through interference with the STAT3 activation pathway in cancer cells. The effect of CPO on STAT3 activation, associated protein kinases and phosphatase, STAT3‐regulated gene products and apoptosis was investiga...
Source: Molecular Carcinogenesis - June 13, 2013 Category: Molecular Biology Authors: Chulwon Kim, Somi K. Cho, Shweta Kapoor, Ansu Kumar, Shireen Vali, Taher Abbasi, Sung‐Hoon Kim, Gautam Sethi, Kwang Seok Ahn Tags: Research Article Source Type: research

Extracts of Koelreuteria henryi Dummer induce apoptosis and autophagy by inhibiting dihydrodiol dehydrogenase, thus enhancing anticancer effects.
Abstract Dihydrodiol dehydrogenase (DDH) is frequently detected in cancer cells, and its overexpression correlates with drug resistance, the downregulation of DNA repair mechanisms, increased frequency of tumor recurrence, cancer cell metastasis and poor prognosis. The silencing of DDH expression using siRNA, on the other hand, reduces drug resistance and cancer cell mobility. These data suggest that DDH may be an oncogene-related protein. However, no specific DDH inhibitor has been identified to date. Thus, in this study, we used DDH as a target enzyme in a live-cell enzyme-linked immunosorbent assay to screen Ch...
Source: International Journal of Molecular Medicine - July 12, 2013 Category: Molecular Biology Authors: Chiang YY, Wang SL, Yang CL, Yang HY, Yang HC, Sudhakar JN, Lee CK, Huang HW, Chen CM, Chiou SH, Chiang SF, Fang HY, Chen CY, Shieh SH, Chow KC Tags: Int J Mol Med Source Type: research

Par‐4 dependent modulation of cellular β‐catenin by medicinal plant natural product derivative 3‐azido Withaferin A
This study, for the first time, reveals 3‐AWA treatment consistently sequestered nuclear β‐catenin and augmented its cytoplasmic pool as evidenced by reducing β‐catenin transcriptional activity in these cells. Moreover, 3‐AWA treatment triggered robust induction of pro‐apoptotic intracellular Par‐4, attenuated Akt activity and rescued Phospho‐GSK3β (by Akt) to promote β‐catenin destabilization. Further, our in vitro studies demonstrate that 3‐AWA treatment amplified E‐cadherin expression along with sharp downregulation of c‐Myc and cyclin D1 proteins. Strikingly, endogenous Par‐4 knock down by s...
Source: Molecular Carcinogenesis - May 12, 2015 Category: Molecular Biology Authors: Hina Amin, Debasis Nayak, Reyaz ur Rasool, Souneek Chakraborty, Anmol Kumar, Khalid Yousuf, Parduman Raj Sharma, Zabeer Ahmed, Neelam Sharma, Asmita Magotra, Debaraj Mukherjee, Lekha Dinesh Kumar, Anindya Goswami Tags: Research Article Source Type: research