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Study of metabolomics in selenium deprived Przewalski's Gazelles ( < em > P. przewalskii < /em > )
Br J Nutr. 2021 Sep 13:1-29. doi: 10.1017/S000711452100355X. Online ahead of print.ABSTRACTTo understand why P. przewalskii does not show the same white myopathy as sheep in Se-deficient regions, and to provide reference for feeding nutrition level of artificial population and selection of wild reintroduction areas in the later period, a Se-deficient model was established. The mineral elements content, physiological and biochemical parameters in blood, and serum metabonomics were determined. In the Se-deficient group compared with the control group, the Se content was highly significantly lower (P<0.01), and the Cu cont...
Source: The British Journal of Nutrition - September 13, 2021 Category: Nutrition Authors: Ting Wu Jian He Xiaoyun Shen Source Type: research

Lessons Learned from Inherited Metabolic Disorders of Sulfur-Containing Amino Acids Metabolism
ABSTRACTThe metabolism of sulfur-containing amino acids (SAAs) requires an orchestrated interplay among several dozen enzymes and transporters, and an adequate dietary intake of methionine (Met), cysteine (Cys), and B vitamins. Known human genetic disorders are due to defects in Met demethylation, homocysteine (Hcy) remethylation, or cobalamin and folate metabolism, in Hcy transsulfuration, and Cys and hydrogen sulfide (H2S) catabolism. These disorders may manifest between the newborn period and late adulthood by a combination of neuropsychiatric abnormalities, thromboembolism, megaloblastic anemia, hepatopathy, myopathy, ...
Source: Journal of Nutrition - October 1, 2020 Category: Nutrition Source Type: research