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Specialty: Physiology
Nutrition: Calcium
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Total 1412 results found since Jan 2013.
Structural and functional analysis of salivary intercalated duct cells reveals a secretory phenotype
J Physiol. 2023 Sep 19. doi: 10.1113/JP285104. Online ahead of print.ABSTRACTCurrently, all salivary ducts (intercalated, striated and collecting) are assumed to function broadly in a similar manner, reclaiming ions that were secreted by the secretory acinar cells while preserving fluid volume and delivering saliva to the oral cavity. Nevertheless, there has been minimal investigation into the structural and functional differences between distinct types of salivary duct cells. Therefore, in this study, the expression profile of proteins involved in stimulus-secretion coupling, as well as the function of the intercalated du...
Source: The Journal of Physiology - September 19, 2023 Category: Physiology Authors: Amanda M Wahl Takahiro Takano Shan Su Blake M Warner Paola Perez James Sneyd David I Yule Source Type: research
Deciphering calcium signals in cells and tissues with tailored probes and models
J Physiol. 2023 Sep 16. doi: 10.1113/JP285037. Online ahead of print.NO ABSTRACTPMID:37715737 | DOI:10.1113/JP285037
Source: The Journal of Physiology - September 16, 2023 Category: Physiology Authors: Nicolas Demaurex Source Type: research
Age-related changes in P2Y receptor signalling in mouse cochlear supporting cells
J Physiol. 2023 Sep 16. doi: 10.1113/JP284980. Online ahead of print.ABSTRACTOur sense of hearing depends on the function of a specialised class of sensory cells, the hair cells, which are found in the organ of Corti of the mammalian cochlea. The unique physiological environment in which these cells operate is maintained by a syncitium of non-sensory supporting cells, which are crucial for regulating cochlear physiology and metabolic homeostasis. Despite their importance for cochlear function, the role of these supporting cells in age-related hearing loss, the most common sensory deficit in the elderly, is poorly understoo...
Source: The Journal of Physiology - September 16, 2023 Category: Physiology Authors: Sarah A Hool Jing-Yi Jeng Daniel J Jagger Walter Marcotti Federico Ceriani Source Type: research
Deciphering calcium signals in cells and tissues with tailored probes and models
J Physiol. 2023 Sep 16. doi: 10.1113/JP285037. Online ahead of print.NO ABSTRACTPMID:37715737 | DOI:10.1113/JP285037
Source: The Journal of Physiology - September 16, 2023 Category: Physiology Authors: Nicolas Demaurex Source Type: research
Age-related changes in P2Y receptor signalling in mouse cochlear supporting cells
J Physiol. 2023 Sep 16. doi: 10.1113/JP284980. Online ahead of print.ABSTRACTOur sense of hearing depends on the function of a specialised class of sensory cells, the hair cells, which are found in the organ of Corti of the mammalian cochlea. The unique physiological environment in which these cells operate is maintained by a syncitium of non-sensory supporting cells, which are crucial for regulating cochlear physiology and metabolic homeostasis. Despite their importance for cochlear function, the role of these supporting cells in age-related hearing loss, the most common sensory deficit in the elderly, is poorly understoo...
Source: The Journal of Physiology - September 16, 2023 Category: Physiology Authors: Sarah A Hool Jing-Yi Jeng Daniel J Jagger Walter Marcotti Federico Ceriani Source Type: research
Deciphering calcium signals in cells and tissues with tailored probes and models
J Physiol. 2023 Sep 16. doi: 10.1113/JP285037. Online ahead of print.NO ABSTRACTPMID:37715737 | DOI:10.1113/JP285037
Source: The Journal of Physiology - September 16, 2023 Category: Physiology Authors: Nicolas Demaurex Source Type: research
Age-related changes in P2Y receptor signalling in mouse cochlear supporting cells
J Physiol. 2023 Sep 16. doi: 10.1113/JP284980. Online ahead of print.ABSTRACTOur sense of hearing depends on the function of a specialised class of sensory cells, the hair cells, which are found in the organ of Corti of the mammalian cochlea. The unique physiological environment in which these cells operate is maintained by a syncitium of non-sensory supporting cells, which are crucial for regulating cochlear physiology and metabolic homeostasis. Despite their importance for cochlear function, the role of these supporting cells in age-related hearing loss, the most common sensory deficit in the elderly, is poorly understoo...
Source: The Journal of Physiology - September 16, 2023 Category: Physiology Authors: Sarah A Hool Jing-Yi Jeng Daniel J Jagger Walter Marcotti Federico Ceriani Source Type: research
Interaction of quercetin and its derivatives with Ca2+-ATPase from sarcoplasmic reticulum: Kinetic and molecular modeling studies
Gen Physiol Biophys. 2023 Sep;42(5):457-468. doi: 10.4149/gpb_2023020.ABSTRACTSarcoplasmic reticulum Ca2+-ATPases (SERCAs) regulate cellular calcium homeostasis and are targeted for age-related diseases. Among 14 SERCA mRNA splice variants, SERCA1a is specific to adult fast-twitch skeletal muscle. Quercetin derivatives (monochloropivaloylquercetin (CPQ), IC50 = 195.7 µM; 2-chloro-1,4-naphthoquinonequercetin (CHNQ), IC50 = 60.3 µM) were studied for their impact on SERCA1a using molecular modeling and enzyme kinetics. While there were some similarities in kinetic parameters and molecular modeling, the compounds exhibited d...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Petronela Rezbarikova Jana Viskupicova Magdalena Majekova Lubica Horakova Source Type: research
Electrophysiological effects of stretch-activated ion channels: a systematic computational characterization
J Physiol. 2023 Sep 4. doi: 10.1113/JP284439. Online ahead of print.ABSTRACTCardiac electrophysiology and mechanics are strongly interconnected. Their interaction is, among others, mediated by mechano-electric feedback through stretch-activated ion channels (SACs). The electrophysiological changes induced by SACs may contribute to arrhythmogenesis, but the precise SAC-induced electrophysiological changes remain incompletely understood. Here, we provide a systematic characterization of stretch effects through three distinguished SACs on cardiac electrophysiology using computational modelling. We implemented potassium-select...
Source: The Journal of Physiology - September 4, 2023 Category: Physiology Authors: Melania Buonocunto Aurore Lyon Tammo Delhaas Jordi Heijman Joost Lumens Source Type: research
