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Activation of Sphingosine Kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance
Conclusion: Sphk2 is transcriptionally upregulated by acute ER stress via activation of ATF4 and improves perturbed hepatic glucose and fatty acid metabolism. This article is protected by copyright. All rights reserved.
Source: Hepatology - March 22, 2015 Category: Internal Medicine Authors: Su‐Yeon Lee, In‐Kyung Hong, Bo‐Rahm Kim, Soon‐Mi Shim, Jae Sung Lee, Hui‐Young Lee, Cheol Soo Choi, Bo‐Kyung Kim, Tae‐Sik Park Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

High expression of PYK2 is associated with poor prognosis and cancer progression in early-stage cervical carcinoma
Proline-rich tyrosine kinase-2 (PYK2), also known as calcium dependent tyrosine kinase, regulates different signal transduction cascades that control cell proliferation, migration, and invasion. However, the role of PYK2 in cervical cancer remains to be elucidated. The current study retrospectively included 134 patients with cervical cancer from December 2007 to September 2014. PYK2 expression was detected in tissue microarray and cervical cancer cell lines. Statistical analysis was performed to evaluate its clinicopathological significance. Small interfering RNA (siRNA) was employed to suppress endogenous PYK2 expression ...
Source: Medicine - October 14, 2022 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research