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Eosinophils as Major Player in Type 2 Inflammation: Autoimmunity and Beyond
Adv Exp Med Biol. 2021 May 26. doi: 10.1007/5584_2021_640. Online ahead of print.ABSTRACTEosinophils are a subset of differentiated granulocytes which circulate in peripheral blood and home in several body tissues. Along with their traditional relevance in helminth immunity and allergy, eosinophils have been progressively attributed important roles in a number of homeostatic and pathologic situations. This review aims at summarizing available evidence about eosinophils functions in homeostasis, infections, allergic and autoimmune disorders, and solid and hematological cancers.Their structural and biological features have b...
Source: Advances in Experimental Medicine and Biology - May 25, 2021 Category: Research Authors: Marco Folci Giacomo Ramponi Ivan Arcari Aurora Zumbo Enrico Brunetta Source Type: research

Identification of a New Human Monoclonal Antibody that More Potently Prevents Malaria Infection
Malaria is a major disease caused by a parasite transmitted through the bite of infected female mosquitoes. Globally, an estimated 214 million cases of malaria and 438,000 deaths from malaria occur annually, with chidren in African and South Asian regions being most vulnerable. Approximately 1,500-2,000 cases of malaria are reported in the United States each year, mostly in returning travelers from malaria- endemic countries. Among the international travelers, military personnel, diplomats, pregnant women, children and older individuals with weakened immune systems are more likely to be at risk of malaria infection and mor...
Source: NIH OTT Licensing Opportunities - November 13, 2020 Category: Research Authors: ott-admin Source Type: research

Enhanced Tissue Clearing Solution, Clearing-Enhanced 3D (Ce3D), Compatible with Advanced Fluorescence Microscopy Imaging
NIH immunologists have created a solution, Clearing-enhanced 3D (Ce3D), that can be used to make entire organs extremely transparent (top right panel). This allows the tissue to be imaged using advanced fluorescence microscopy techniques (bottom panel). Unlike current tissue clearing solutions, the Ce3D tissue clearing solution is robustly compatible with a variety of staining methods, and preserves tissue morphology and reporter fluorescence. Ce3D enabled microscopy provides unprecedented insight into the spatial organization of cells within intact organs. Further, when Ce3D enabled microscopy is coupled with multiplexed ...
Source: NIH OTT Licensing Opportunities - January 19, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Compositions and Methods for Blocking Transmission of Plasmodium
According to the World Health Organization, about 3.2 billion people – nearly half of the world ' s population – are at risk of infection by Plasmodium parasites, resulting in malaria. An estimated 214 million cases and 438,000 deaths were due to malaria in 2015.P47 protein expressed by Plasmodium species allow malaria parasites to evade the mosquito immune system, thereby facilitating the transmission of malaria parasites. NIAID inventors have discovered the region of P47 protein responsible for the immune evasion function of this protein. Specific sequences of protein fragments of P47 have proven to be both highly an...
Source: NIH OTT Licensing Opportunities - January 11, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Compounds That Treat Malaria and Prevent Malaria Transmission
Malaria is the single leading cause of death, especially among children, in the developing world. Malaria is caused by infection with parasites of the genusPlasmodium, transmitted by mosquitos. In addition to transmission, vital steps in the parasite lifecycle occur in the mosquito host. The invention offered for licensing relates to therapeutic compounds and related pharmaceutical compositions that can be used in the prevention and treatment of malaria infection. More specifically, the invention is drawn to compounds that may kill sexual and mosquito stage malaria parasites to block transmission. Specifically claimed is t...
Source: NIH OTT Licensing Opportunities - July 18, 2017 Category: Research Authors: ajoyprabhu3 Source Type: research

AMA1-RON2 Complex-Based Vaccine Against Malaria
This technology relates to a malaria vaccine composed of a protein complex of Apical Membrane Antigen (AMA1) and rhoptry neck protein 2 (RON2) with an adjuvant. AMA1 is a crucial component of thePlasmodium invasion machinery and is a leading candidate for antimalarial vaccine development. AMA1-based vaccines have shown ability to block red cell invasion inin vitro assays, but protection has so far not translated toin vivo human infections. NIAID investigators have demonstrated that interaction between AMA1 and RON2 (or peptide thereof) is essential for malaria parasites to successfully enter human red blood cells (RBCs). V...
Source: NIH OTT Licensing Opportunities - March 9, 2017 Category: Research Authors: ajoyprabhu3 Source Type: research

AMA1-RON2 Complex-based Vaccine Against Malaria
This technology relates to a malaria vaccine composed of a protein complex of Apical Membrane Antigen (AMA1) and rhoptry neck protein 2 (RON2) with an adjuvant. AMA1 is a crucial component of the Plasmodium invasion machinery and is a leading candidate for antimalarial vaccine development. AMA1-based vaccines have shown ability to block red cell invasion in in vitro assays, but protection has so far not translated to in vivo human infections. NIAID investigators have demonstrated that interaction between AMA1 and RON2 (or peptide thereof) is essential for malaria parasites to successfully enter human red blood cells (RBCs...
Source: NIH OTT Licensing Opportunities - June 18, 2014 Category: Research Authors: admin Source Type: research

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