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Rare case of homozygous ifnar1 deficiency in a samoan child with disseminated varicella after vaccination
Autosomal recessive interferon alpha/beta receptor 1 (IFNAR1) deficiency increases susceptibility to live-attenuated vaccines and wild-type viruses. Currently 16 cases, half with Polynesian ancestry have been reported since the discovery in 2019. Most cases present with severe MMR or yellow fever vaccine-related disease. Some cases report severe SARS-CoV-2, herpes simplex, and enterovirus. Varicella vaccine-related disease has been hypothesized but not previously reported.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: M. Revier, N. Scanlon, M. Lee, C. Collins, S. Laubach Tags: M247 Source Type: research

Transcutaneous yellow fever vaccination of subjects with or without atopic dermatitis
Conclusions: YFV vaccination of patients with AD through the transcutaneous route revealed that high baseline IgE levels provide a potential biomarker for predicting reduced virus-specific immune memory after transcutaneous infection with a live virus.
Source: Journal of Allergy and Clinical Immunology - December 12, 2013 Category: Allergy & Immunology Authors: Mark K. Slifka, Donald Y.M. Leung, Erika Hammarlund, Hans-Peter Raué, Eric L. Simpson, Susan Tofte, Shahana Baig-Lewis, Gloria David, Henry Lynn, Rob Woolson, Tissa Hata, Henry Milgrom, Jon Hanifin Tags: Atopic dermatitis and skin disease Source Type: research