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Molecules, Vol. 27, Pages 8316: Pharmacological and Clinical Efficacy of Picrorhiza kurroa and Its Secondary Metabolites: A Comprehensive Review
This study comprehensively evaluated the ethnopharmacological efficacy, phytochemistry, pharmacological activity, dose, and toxicity of P. kurroa. This review provides comprehensive insights into this traditional medication for future research and therapeutic application. The purpose of this review article was to determine the pharmacological effects of P. kurroa on a variety of disorders. P. kurroa may be a natural alternative to the standard treatment for eradicating newly evolving diseases. This study is intended as a resource for future fundamental and clinical investigations.
Source: Molecules - November 29, 2022 Category: Chemistry Authors: Tahani M. Almeleebia Abdulrhman Alsayari Shadma Wahab Tags: Review Source Type: research

The Introduction of Hydrazone, Hydrazide or Azepane Moieties to the Triterpenoid Core Enhances an Activity Against M. tuberculosis.
CONCLUSIONS: It was revealed that conjugation of lupanes with INH at C3 is more effective than at C28 and lupane skeleton is preferable among oleanane and ursane types. The replacement of native hexacarbocyclic A ring to seven-member azepane ring is favorably for inhibition of both MTB H37RV and SDR-strains. These data could possibly mean that the antitubercular activity against INH-resistant strains (INH-R) came from both triterpenoid and isoniazid parts of the hybrid molecules. Azepanobetulin showed the highest activity against both INH-R strains in comparison with other triterpenoids and INH. Thus, the introduction of h...
Source: Medicinal Chemistry - January 14, 2020 Category: Chemistry Authors: Kazakova OB, Medvedeva NI, Smirnova IE, Lopatina TV, Veselovsky AV Tags: Med Chem Source Type: research

Microwave-assisted Synthesis of 2-Styrylquinoline-4-carboxylic Acids as Antitubercular Agents.
Conclusion: Three compounds had activity under aerobic conditions. PMID: 27585570 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - August 31, 2016 Category: Chemistry Authors: Muscia GC, Asis SE, Buldain GY Tags: Med Chem Source Type: research

Design, synthesis and evaluation of acridine and fused-quinoline derivatives as potential anti-tuberculosis agents.
Abstract The synthesis of twelve acridine and polycyclic acridine derivatives prepared via the Friedländer reaction is described. The one-pot reactions of 2-amino-5-chloro or 5-nitro-benzophenones and a variety of cyclanones and indanones were carried out in a MW oven under TFA catalysis in good yields. The products were designed according natural antituberculosis products and were evaluated for growth inhibitory activity towards Mycobacterium tuberculosis H37Rv (Mtb) through the National Institute of Allergy and Infectious Diseases (NIAID, USA). Three of them underwent additional testings. The cyclopenta[b]quino...
Source: European Journal of Medicinal Chemistry - December 25, 2013 Category: Chemistry Authors: Muscia GC, Buldain GY, Asís SE Tags: Eur J Med Chem Source Type: research