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Specialty: Molecular Biology
Infectious Disease: Hepatitis

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Total 17 results found since Jan 2013.

A human proteome microarray identifies that the heterogeneous nuclear ribonucleoprotein K (hnRNP K) recognizes the 5 ' terminal sequence of the hepatitis C virus RNA.
In this study, we employed a human proteome microarray, comprised of ~17,000 individually purified human proteins in full-length, and identified 313 proteins that recognize HCV SL1. Eighty-three of the identified proteins were annotated as liver-expressing proteins, and twelve of which were known to be associated with hepatitis virus. siRNA-induced silencing of 8 out of 12 candidate genes led to at least 25% decrease in HCV replication efficiency. In particular, knockdown of heterogeneous nuclear ribonucleoprotein K (hnRNP K) reduced HCV replication in a concentration-dependent manner. UV-crosslinking assay also showed tha...
Source: Molecular and Cellular Proteomics : MCP - October 10, 2013 Category: Molecular Biology Authors: Fan B, Lu KY, Sutandy FX, Chen YW, Konan K, Zhu H, Kao CC, Chen CS Tags: Mol Cell Proteomics Source Type: research

Interferon alpha and ribavirin collaboratively regulate p38 mitogen-activated protein kinase signaling in hepatoma cells.
Abstract Signaling events triggered by interferon alpha (IFN-α) and ribavirin are involved in anti-hepatitis C virus (HCV) action. The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in HCV pathogenesis. Effects of IFN-α and ribavirin on p38 MAPK signaling were investigated in human hepatoma cells. Type I IFN receptor 2 (IFNAR2) mediated IFN-α-induced p38 MAPK phosphorylation. Also, p38 MAPK phosphorylation was enhanced by ribavirin. Treatment for 48h with a combination of IFN-α and ribavirin increased p38 MAPK phosphorylation, whereas the treatment for 72h reduced p38 MAPK phosphor...
Source: Cytokine - February 11, 2013 Category: Molecular Biology Authors: He SF, Wang W, Ren H, Zhao LJ, Qi ZT Tags: Cytokine Source Type: research