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Infectious Disease: Hepatitis
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Total 297 results found since Jan 2013.
Pharmacokinetics of Jnj-73763989 And Jnj-56136379 (Bersacapavir) In Participants With Moderate Hepatic Impairment
This article is protected by copyright. All rights reserved.PMID:36786053 | DOI:10.1002/jcph.2214
Source: The Journal of Clinical Pharmacology - February 14, 2023 Category: Drugs & Pharmacology Authors: Thomas N Kakuda Atef Halabi Gernot Klein Madhu Sanga Carine Guinard-Azadian Monika Kowalik Katja Nedoschinsky Julius Nangosyah Emmanuel Njumbe Ediage Vera Hillewaert Peter Verboven Ivo Goris Jan Snoeys Martyn Palmer Michael Biermer Source Type: research
Suppression of SIRT1/FXR signaling pathway contributes to oleanolic acid-induced liver injury
In conclusion, our study reveals that SIRT1/FXR pathway is crucial in OA-induced hepatotoxicity. Activation of SIRT1/HNF1α/FXR axis may represent a novel therapeutic target for ameliorating OA and other herb-induced hepatotoxicity.PMID:37028458 | DOI:10.1016/j.taap.2023.116509
Source: Toxicology and Applied Pharmacology - April 7, 2023 Category: Toxicology Authors: Songjie Liao Xiaolong Fu Jianxiang Huang Yi Wang Yuanfu Lu Shaoyu Zhou Source Type: research
Calcitriol attenuates liver fibrosis through hepatitis C virus nonstructural protein 3-transactivated protein 1-mediated TGF β1/Smad3 and NF-κB signaling pathways
CONCLUSION: Our results suggest that calcitriol may be employed as an adjuvant therapy for hepatic fibrosis and that NS3TP1 is a unique, prospective therapeutic target in hepatic fibrosis.PMID:37274069 | PMC:PMC10237113 | DOI:10.3748/wjg.v29.i18.2798
Source: World Journal of Gastroenterology : WJG - June 5, 2023 Category: Gastroenterology Authors: Liu Shi Li Zhou Ming Han Yu Zhang Yang Zhang Xiao-Xue Yuan Hong-Ping Lu Yun Wang Xue-Liang Yang Chen Liu Jun Wang Pu Liang Shun-Ai Liu Xiao-Jing Liu Jun Cheng Shu-Mei Lin Source Type: research
