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Infectious Disease: Gastroenteritis
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Total 621 results found since Jan 2013.
Wharton's Jelly Mesenchymal Stem Cells-derived Exosomes and Imipenem in Combination Reduce Apoptosis and Inflammatory Responses in E.coli-infected HepG2 Cells
In this study, we investigated the immunomodulatory effect of Wharton's jelly MSC-derived exosomes in combination with imipenem on HepG2 cells infected with Escherichia col i.MSC-derived exosomes were separated from MSCs, which were isolated by flow cytometry. Scanning electron microscopy and dynamic light scanning were used to confirm the presence of exosomes. Quantitative real-time PCR, ELISA, and nitric oxide assay were used to assess the inflammatory response in the infected cells. Annexin-PI was used to measure the extent of apoptosis. The results showed that the combination of imipenem and MSC-derived exosomes were m...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Ali Hazrati Sara Soudi Seyed Mahmoud Hashemi Source Type: research
Generation of high affinity ICAM-1-specific nanobodies and evaluation of their suitability for allergy treatment
In conclusion, our results showed that the selected ICAM-1-specific nanobody bound ICAM-1 with high affinity and was not internalized. Thus, it could be further used to engineer heterodimers with allergen-specific nanobodies in order to develop topical treatments of pollen allergy.
Source: Frontiers in Immunology - November 9, 2022 Category: Allergy & Immunology Source Type: research
Detection of Novel Autoantibodies to Nucleolin's RNA-binding Domains as a Serum Tumor Biomarker Through ELISA
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):616-625. doi: 10.18502/ijaai.v21i6.11520.ABSTRACTExpression and location of nucleolin are often abnormal in malignancies, which may result in the production of autoantibodies. Despite this, the identification of such autoantibodies may be essential for the early diagnosis and prognosis of cancers. In this investigation, the recombinant nucleolin protein was generated using an Escherichia coli expression system and was used an indirect enzyme-linked immunosorbent assay to detect anti-nucleolin autoantibodies in cancer patients' sera. Lung cancer patients' autoantibodies displ...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Fatemeh Ezzatifar Alireza Rafiei Reza Valadan Hossein Asgarian-Omran Mahmood Jeddi-Tehrani Source Type: research
