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Oligonucleotides —A Novel Promising Therapeutic Option for IBD
Conclusions In this review, we focused on recent and past approaches to test the therapeutic efficacy of oligonucleotide based therapies in IBD. The combining mechanistic mode of oligonucleotide based therapeutics is a targeted action on specific pro-inflammatory molecules, which are over activated in IBD patients and contribute significantly to disease pathogenesis. The proposed high selectivity of the agents is derived from its mode of action, that aims to specifically block certain inflammatory molecular patterns, without a general systemic effect on other molecular targets. It would be important for each oligonucleot...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Apoptotic enteropathy caused by antimetabolites and TNF-{alpha} antagonists
Conclusions Pathologists should be aware of the expanding spectrum of drugs that can cause apoptotic enteropathy, including antimetabolites and tumour necrosis factor-α inhibitors.
Source: Journal of Clinical Pathology - June 19, 2014 Category: Pathology Authors: Soldini, D., Gaspert, A., Montani, M., Reineke, T., Rogler, G., Odze, R., Weber, A. Tags: Neurogastroenterology, Immunology (including allergy), Clinical diagnostic tests Original article Source Type: research