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Source: European Review for Medical and Pharmacological Sciences
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Total 305 results found since Jan 2013.
CircRNA 010567 improves myocardial infarction rats through inhibiting TGF- β1.
CONCLUSIONS: CircRNA 010567 siRNA can improve the cardiac function, alleviate the MF, and inhibit the myocardial apoptosis, thereby further suppressing MI-induced MF, whose mechanism may be related to the inhibition on the TGF-β1 signaling pathway.
PMID: 31957851 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - January 21, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Dysregulation of microRNA-770-5p influences pancreatic- β-cell function by targeting TP53 regulated inhibitor of apoptosis 1 in gestational diabetes mellitus.
CONCLUSIONS: The data demonstrated that miR-770-5p was a vital regulator in pancreatic β-cell proliferation, apoptosis and insulin secretion by targeting TRIAP1, and dysregulation of miR-770-5p resulted in the development of GDM via APAF1 signaling pathway.
PMID: 32016984 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - February 6, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MiR-1301 promotes adipogenic and osteogenic differentiation of BMSCs by targeting Satb2.
CONCLUSIONS: Regulation of miR-1301 expression in BMSCs can improve BMSCs proliferation and regulate their adipogenic and osteogenic differentiation by regulating Satb2.
PMID: 32329823 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - April 26, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Effects of homeodomain-interacting protein kinase 2 on renal tubular epithelial cells.
CONCLUSIONS: Inhibition of HIPK2 expression can promote H/R-induced proliferation of NRK-52E cells through the JAK2/STAT3 signaling pathway, relieve the OS response, and reduce apoptosis.
PMID: 32572889 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 25, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Astaxanthin protecting myocardial cells from hypoxia/reoxygenation injury by regulating miR-138/HIF-1 α axis.
CONCLUSIONS: AST can exert a protective function in myocardial cells via regulating the expression of miR-138/HIF-1α axis.
PMID: 32744699 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - August 5, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
LncRNA UCA1 regulates cervical cancer survival and EMT occurrence by targeting miR-155.
CONCLUSIONS: UCA1 expression in cervical cancer is increased and related to patient survival and miR-155 expression is reduced. Lnc-RNA UCA1 regulates EMT occurrence in cervical cancer cells by targeting miR-155.
PMID: 33090390 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - October 23, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Effect of TLR7 gene expression mediating NF- κB signaling pathway on the pathogenesis of bronchial asthma in mice and the intervention role of IFN-γ.
CONCLUSIONS: Upregulation of TLR7 can inhibit the activation of NF-κB signaling pathway, reduces airway inflammation, inhibits ASMCS proliferation and thus promotes cell apoptosis in asthmatic mice. Besides, IFN-γ can exert a protective role in suppressing the progression of inflammation in asthma.
PMID: 33577041 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - February 14, 2021 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Cyclin I promotes cisplatin resistance via Cdk5 activation in cervical cancer.
CONCLUSIONS: These data suggest that a cyclin I-Cdk5 complex forms a critical antiapoptotic factor in the process of generating cisplatin resistance in cervical cancer.
PMID: 26698249 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 25, 2015 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Clinical significance of sCIP2A levels in breast cancer.
CONCLUSIONS: Our results suggest that serum CIP2A is significantly higher in patients with breast cancer, which is a potential biomarker to make a distinction between breast cancer patients and healthy controls. Higher serum CIP2A levels positively associated with the aggressive phenotype of breast cancer, and forecasts poor prognosis for patients with breast cancer. Knockdown of CIP2A may be a novel target for prevention and treatment of breast cancer.
PMID: 26813457 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - January 29, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Laryngeal squamous cell carcinoma progression is associated with the NFκB signaling pathway regulated by IκB kinase β.
CONCLUSIONS: The NFκB signaling pathway involved TNFR1, IKK-β, and FADD is significantly associated with the development of LSCC. Over-expressed IKK-β efficiently inhibits cell apoptosis and has positive effects on cell proliferation and migration.
PMID: 26914121 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - February 27, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
USP4 promotes invasion of breast cancer cells via Relaxin/TGF-β1/Smad2/MMP-9 signal.
CONCLUSIONS: Therapies targeting the USP4 inhibits invasion of breast cancer cells via Relaxin/TGF-β1/Smad2/MMP-9 signal. These results indicate that USP4 is an attractive target for breast cancer therapy.
PMID: 27049265 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 8, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
ERK1/2/p53 and NF-κB dependent-PUMA activation involves in doxorubicin-induced cardiomyocyte apoptosis.
CONCLUSIONS: DOX induced apoptosis and inhibited growth of H9c2 cells by activation of ERK1/2/p53 and NF-κB dependent-PUMA signaling pathway.
PMID: 27338072 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 25, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Vitamin E promotes breast cancer cell proliferation by reducing ROS production and p53 expression.
CONCLUSIONS: Vitamin E accelerated breast cancer growth by reducing ROS production and p53 expression.
PMID: 27383327 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 9, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
HIFs-MiR-33a-Twsit1 axis can regulate invasiveness of hepatocellular cancer cells.
CONCLUSIONS: MiR-33a downregulation in HCC cells is hypoxia-induced and is a result of HIFs upregulation. MiR-33a can modulate EMT and invasion of hepatocellular cancer cells at least partly via downregulating Twist1.
PMID: 27460728 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 29, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MiR-200c and miR-141 inhibit ZEB1 synergistically and suppress glioma cell growth and migration.
CONCLUSIONS: MiR-200c and miR-141 are significantly downregulated in glioma tissues and cell lines and can significantly induce ZEB1 mRNA degradation and suppress ZEB1 protein expression in the cells. ZEB1 is a functional downstream target of miR-200c and miR-141 in inhibiting glioma cell growth and migration.
PMID: 27608897 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - September 10, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
