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Source: Oncology Letters

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Total 221 results found since Jan 2013.

Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells.
Authors: Niu L, Liu A, Xu W, Yang L, Zhu W, Gu Y Abstract Peroxiredoxin (Prx) II is an imperative member of the superfamily of peroxidases. It serves an essential role in scavenging organic hydroperoxide and H2O2. It is involved in the development of various malignant tumors. In order to investigate the significance of Prx II expressions level in gastric cancer (GC), downregulation of Prx II was performed to investigate its role in the proliferation and migration of gastric adenocarcinoma cells. In GC cells and 45 GC specimens, the mRNA and protein expression levels of Prx II were determined using reverse transcrip...
Source: Oncology Letters - September 16, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

High serum Ephrin-B2 levels predict poor prognosis for patients with gastric cancer.
Authors: Yue WJ, Liu YP, Li M, Liu CX, Mou SJ, Li QK, Chen ZP Abstract Gastric cancer is an intractable disease with a poor prognosis and limited treatment options. Its treatment remains a major clinical challenge worldwide. Ephrin-B2 is upregulated and involved in tumor growth in various types of cancer. However, the association between ephrin-B2 and prognosis of gastric cancer, and the potential of ephrin-B2 as a therapeutic target remains unknown. The present study investigated ephrin-B2 as a prognostic factor and a therapeutic target for gastric cancer. Reverse transcription-quantitative polymerase chain reacti...
Source: Oncology Letters - September 16, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Downregulation of lncRNA PVT1 expression inhibits proliferation and migration by regulating p38 expression in prostate cancer.
Authors: Wan B, Wu HY, Lv DJ, Zhou XM, Zhong LR, Lei B, Zhang SB, Mao XM Abstract Long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been reported to be overexpressed in prostate cancer cells and associated with tumorigenesis in various types of cancer. However, the biological function of lncRNA PVT1 remains largely unknown. The aim of the present study was to investigate the effect of lncRNA PVT1 expression on the proliferation and migration of prostate cancer cells. Stably transfected prostate cancer cells with downregulated expression of lncRNA PVT1 were constructed by an efficient siRN...
Source: Oncology Letters - September 26, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Expression of Smo in pancreatic cancer CD44+CD24+cells and construction of a lentiviral expression vector to silence Smo.
Authors: Cong P, Yi C, Wang XY Abstract The present study focused on the roles of members of the Hedgehog (Hh) signaling pathway in the maintenance of malignant biological characteristics, such as tumorigenesis, similar to that of pancreatic tumor cells. Cluster of differentiation (CD)44+CD24+/CD44-CD24- cells were isolated from three different pancreatic cancer cell lines by flow cytometry. Among the three pancreatic cancer cell lines, the SW1990 cell line exhibited the highest percentage of CD44+CD24+ cells, which accounted for 39.9% of the total. The expression of members of the Hh signaling pathway in CD44+CD24...
Source: Oncology Letters - September 26, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Hepatocyte growth factor-induced mesenchymal-epithelial transition factor activation leads to insulin-like growth factor 1 receptor inhibitor unresponsiveness in gastric cancer cells.
In conclusion, HGF-induced MET activation may represent a novel mechanism conferring unresponsiveness to IGF-1R-targeted agents in GC, and inhibition of MET may improve the efficacy of IGF-1R inhibitors. PMID: 30333869 [PubMed]
Source: Oncology Letters - October 21, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Acidosis promotes cell apoptosis through the G protein-coupled receptor 4/CCAAT/enhancer-binding protein homologous protein pathway.
Authors: Dong B, Zhang X, Fan Y, Cao S, Zhang X Abstract The aim of the present study was to investigate the effects of acidosis on the apoptosis of renal epithelial and endothelial cells, and the molecular pathways responsible for this. A human proximal tubular cell line, HK-2, and human umbilical vein endothelial cells (HUVECs), were transfected with control or G protein-coupled receptor 4 siRNA for 36 h. Cells were exposed to normal (pH 7.4) or acidic (pH 6.4) media. Western blot analysis was used to assess the protein expression levels of G protein-coupled receptor 4 (GPR4), CCAAT/enhancer-binding protein homol...
Source: Oncology Letters - November 9, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Knockdown of LETM1 inhibits proliferation and metastasis of human renal cell carcinoma cells.
In conclusion, these results suggest that knockdown of LETM1 exhibits tumor suppressive effects, at least in part by controlling the downstream Wnt/β-Catenin signaling pathway. Therefore, LETM1 may act as a novel therapeutic target for the treatment of RCC. PMID: 30405774 [PubMed]
Source: Oncology Letters - November 9, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

The role of the fat mass and obesity-associated protein in the proliferation of pancreatic cancer cells.
Authors: Tang X, Liu S, Chen D, Zhao Z, Zhou J Abstract Fat mass and obesity-associated (FTO) protein has been identified as a critical demethylase in regulating cellular mRNA stability by removing N6-methyladenosine (m6A) residues in mRNA. Even though the role of FTO in body energy metabolism has been well established, its role in cancer cell homeostasis remains unclear. In the present study, by using RNA interference, it was indicated that FTO is required for pancreatic cancer cell proliferation. Knockdown of FTO resulted in compromised proliferation of pancreatic cancer cells. Furthermore, DNA synthesis was comp...
Source: Oncology Letters - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

miR-127 suppresses gastric cancer cell migration and invasion via targeting Wnt7a.
In conclusion, miR-127 could curb GC cell migration and invasion by upregulating Wnt7a, indicating its potential application in GC diagnosis and therapy. PMID: 30867752 [PubMed]
Source: Oncology Letters - March 16, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

The oncogenic role of Wnt10a in colorectal cancer through activation of canonical Wnt/ β-catenin signaling.
In conclusion, the present study demonstrated that Wnt10a may have an oncogenic role during carcinogenesis of CRC through activation of Wnt/β-catenin signaling. PMID: 30881490 [PubMed]
Source: Oncology Letters - March 19, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Rapamycin enhanced the antitumor effects of doxorubicin in myelogenous leukemia K562 cells by downregulating the mTOR/p70S6K pathway.
Authors: Li J, Liu W, Hao H, Wang Q, Xue L Abstract Chronic myelogenous leukemia (CML) is a common hematological malignancy. Some patients progressing to the blast phase develop chemotherapeutic drug resistance. In the authors' previous study, it was found that the mammalian target of rapamycin (mTOR) pathway was activated in CML and that rapamycin inhibited the proliferation of K562 cells. Targeting the mTOR pathway may be used in combination with chemotherapeutic drugs to enhance their efficacy and overcome multidrug resistance. The aim of the present study was to investigate the effects of rapamycin and doxorubi...
Source: Oncology Letters - August 14, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

A combination of inhibitors of glycolysis, glutaminolysis and de novo fatty acid synthesis decrease the expression of chemokines in human colon cancer cells.
Authors: Schcolnik-Cabrera A, Dominguez-Gómez G, Chávez-Blanco A, Ramírez-Yautentzi M, Morales-Bárcenas R, Chávez-Díaz J, Taja-Chayeb L, Dueáas-González A Abstract Lonidamine, 6-Diazo-5-oxo-L-norleucine (DON) and orlistat are well known inhibitors of glycolysis, glutaminolysis and of de novo fatty acid synthesis, respectively. Although their antitumor effects have been explored in detail, the potential inhibition of the malignant metabolic phenotype and its influence on the expression of chemokines and growth factors involved in colon cancer, have not been previously reported to the best of our knowledge. I...
Source: Oncology Letters - December 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

microRNA-144 inhibits cell proliferation and invasion by directly targeting TIGAR in esophageal carcinoma.
Authors: Mu Y, Wang Q, Tan L, Lin L, Zhang B Abstract microRNAs (miRNAs) have been identified to play vital roles in the development and progression of numerous different types of human malignancy, including esophageal squamous cell carcinoma (ESCC). In the present study, the biological function of microRNA-144 (miR-144) was investigated, as well as its underlying molecular mechanism in ESCC. The results revealed that miR-144 expression was significantly decreased, whereas the expression of TP53-inducible glycolysis and apoptosis regulator (TIGAR) was significantly increased in human ESCC tissues when compared with...
Source: Oncology Letters - April 8, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Long non-coding RNA GAS5 is critical for maintaining stemness and induces chemoresistance in cancer stem-like cells derived from HCT116.
Authors: Zhou X, Xiao D Abstract Long non-coding RNAs (lncRNAs) are recognized as critical regulators of self-renewal in human cancer stem-like cells (CSCs), which are a subpopulation of cancer cells primarily responsible for the malignant features of cancer. However, most CSC-related lncRNAs remain unidentified. The results of the present study suggested that growth-arrest-specific transcript 5 (GAS5), a tumor suppressor, exhibited increased expression and was associated with malignant features in human colorectal cancer cell HCT116-derived CSCs. Phenotypic analysis indicated that GAS5 knockdown by specific siRNA ...
Source: Oncology Letters - April 11, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Downregulation of FHL1 protein in glioma inhibits tumor growth through PI3K/AKT signaling.
In conclusion, the results of the present study demonstrated that FHL1 suppressed glioma development through PI3K/AKT signaling. PMID: 32382330 [PubMed]
Source: Oncology Letters - May 10, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research