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The TL1A-DR3 Axis in Asthma: Membrane-Bound and Secreted TL1A Co-Determined the Development of Airway Remodeling
CONCLUSIONS: Our results confirm differential TL1A expression (including its secreted and non-secreted form) in asthma, which modulates remodeling. The shared mechanism of action by which nsTL1A and secreted TL1A exert their effects on asthma development might be mediated via the nuclear factor-κB pathway. The TL1A-DR3 axis presents a promising therapeutic target in asthma.PMID:35255540 | PMC:PMC8914606 | DOI:10.4168/aair.2022.14.2.233
Source: Allergy, Asthma and Immunology Research - March 7, 2022 Category: Allergy & Immunology Authors: Jintao Zhang Dong Zhang Yun Pan Xiaofei Liu Jiawei Xu Xinrui Qiao Wenjing Cui Liang Dong Source Type: research

Epithelial PI3K- δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners.
CONCLUSIONS: The results of this study suggest that PI3K-δ-isoform can promote HDM-induced allergic airway inflammation via NLRP3 inflammasome-dependent response as well as via NLRP3 inflammasome-independent epithelial cell activation. PMID: 32009326 [PubMed]
Source: Allergy, Asthma and Immunology Research - February 7, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

TRPV1 Blocking Alleviates Airway Inflammation and Remodeling in a Chronic Asthma Murine Model.
CONCLUSIONS: Treatment directed at TRPV1 significantly alleviated AHR, airway inflammation, and remodeling in a chronic asthma murine model. The TRPV1 receptor can be a potential drug target for chronic bronchial asthma. PMID: 29676068 [PubMed]
Source: Allergy, Asthma and Immunology Research - April 22, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Alteration in Claudin-4 Contributes to Airway Inflammation and Responsiveness in Asthma.
CONCLUSIONS: These findings thus raise the possibility that regulation of lung epithelial barrier proteins may constitute a therapeutic approach for asthma. PMID: 29178675 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 29, 2017 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Synergistic Effect of Dermatophagoides farinae and Lipopolysaccharides in Human Middle ear Epithelial Cells.
CONCLUSIONS: When Der f treatment preceded LPS exposure, Der f and LPS acted synergistically in the induction of pro-inflammatory cytokines and the MUC gene, suggesting an important role in the development of OME in patients with concealed allergy airway sensitization. PMID: 27334783 [PubMed]
Source: Allergy, Asthma and Immunology Research - June 24, 2016 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Alternaria Induces Production of Thymic Stromal Lymphopoietin in Nasal Fibroblasts Through Toll-like Receptor 2.
CONCLUSIONS: The results of this study show that TSLP expression could be induced in nasal fibroblasts by exposure to Alternaria and that TLR2 may be involved in the process. The promotion of TSLP production in nasal fibroblasts by airborne fungi may facilitate the development or exacerbation of Th2-type nasal inflammation, especially in CRS with nasal polyps. PMID: 26540503 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 7, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

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