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Source: European Respiratory Journal
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Total 164 results found since Jan 2013.
DJ-1 and its anti-oxidative stress response regulates the expression of sirtuin-1 in COPD epithelial cells
Conclusions: DJ-1 binds and regulates the expression of SIRT1 in epithelial cells. As both DJ-1 and SIRT1 were down-regulated in COPD, the association of these molecules may be a mechanism of impaired anti-ageing and defence against oxidative stress in COPD.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Koga, T., Vuppusetty, C., Ito, K., Barnes, P. J., Baker, J. R. Tags: Airway Cell Biology and Immunopathology Source Type: research
TGF-{beta} participates in epithelial-mesenchymal transition in pleural fibrosis via targeting S100A4
In this study, we detected the expression of S100A4, EMT- and ECM-related markers in Met-5A cells treated with TGF-β or TGF-β inhibitor by real-time PCR, western blot and ELISA. In order to explore the role of S100A4, we used siRNA to knock down the expression of S100A4 in cell model. We found the expression of epithelial cell marker was decreased and the mesenchymal cell marker increased with ECM deposition and S100A4 up-regulation after treatment with TGF-β. Moreover, the changes of EMT-related event were restricted when the expression of S100A4 was knocked down. Conversely, S100A4 can partially rescue the...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Sun, Z., Ning, Q., Li, F., Wang, L., Li, H., Yao, Y., Hu, T. Tags: Pleural and Mediastinal Malignancies Source Type: research
Transcriptional Profiling reveals Reprogramming of Airway Basal Cells in IPF
Conclusion: airway basal cells derived from distal airways are reprogrammed in IPF which results in malfunction and mislead repair processes.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Prasse, A., Jäger, B., Carleo, A., Jonigk, D., DeLuca, D. Tags: Mechanisms of Lung Injury and Repair Source Type: research
Cigarette smoke exposure decreases CFLAR expression in bronchial epithelium, augmenting susceptibility for cell death and DAMP release
In conclusion, CS exposure decreases CFLAR expression, which might increase susceptibility to immunogenic cell death. Our study suggests that susceptibility for CS-induced airway inflammation is driven by dysregulated cell death machinery, which may be used at target for future COPD treatments.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Pouwels, S. D., Faiz, A., Heijink, I. H., Vermeulen, C. J., Guryev, V., Van Den Berge, M., Nawijn, M. C. Tags: Mechanisms of Lung Injury and Repair Source Type: research
Alternative Polyadenylation(APA) modulates extracellular matrix deposition in pulmonary hypertension
Cleavage and polyadenylation is an important and regulated step in the maturation of mRNAs. Alternative polyadenylation (APA) is typically a shortening of the 3’UTR of affected gene by using a second polyadenylation signal. This shortening can remove regulation and can lead to increased expression of these mRNAs. APA induced by the depletion of the 25kDa subunit of cleavage factor I (CFIm25) has been shown to affect transcripts encoding for extracellular matrix (ECM) Proteins. This leads to the hypothesis that APA due to reduced CFIm25 expression could play a role in modulating ECM production of pulmonary vasculature...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Collum, S., Weng, T., Hernandez, A., Mertens, T., Chen, N., Guha, A., Youker, K., Wagner, E., Han, L., Blackburn, M., Karmouty-Quintana, H. Tags: Pulmonary Hypertension Source Type: research
FKBP10 regulates fibroblast migration via synthesis of collagen VI
Conclusion: FKBP10 deficiency in phLF attenuates migration mainly by decreased synthesis of collagen VI.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Knüppel, L., Heinzelmann, K., Lindner, M., Hatz, R., Behr, J., Eickelberg, O., Staab-Weijnitz, C. Tags: Mechanisms of Lung Injury and Repair Source Type: research
Role of Mitogen activated-kinase (MAPK)-phosphatase (MKP)-5 in pulmonary fibrosis
Conclusion: Intact MKP5 is required for induction of changes in lung fibroblasts in-vitro and during bleomycin-induced lung fibrosis in-vivo. MKP5 inhibition represent a promising therapeutic target for experimental and lung fibrosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Tzouvelekis, A., Karampitsakos, T., Min, K., Xylourgidis, N., Yu, G., Herazo-Maya, J., Bizenhofer, L., Bennett, A., Kaminski, N. Tags: Idiopathic interstitial pneumonias Source Type: research
Krüppel-like factor 4 (Klf4) is a novel regulator of neonatal lung fibroblast homeostasis and reduced in hyperoxia-induced lung injury
Conclusion: We identify Klf4 as a novel key regulator of neonatal lung fibroblast homeostasis. Loss of Klf4 is intimately linked to myofibroblast activation, fibrosis and migration, eventually reducing thereby alveolar formation and contributing to the pathogeneis of BPD.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Hirani, D., Koch, M., Dinger, K., Mohr, J., Vohlen, C., Klaudt, C., Dötsch, J., Alejandre Alcazar, M. A. Tags: Lung and airway developmental biology Source Type: research
Role of TREM1-Ripk3 axis in hyperoxia induced lung injury in neonates.
Hyperoxia-induced lung injury (HALI) is one of the major contributor to the development of bronchopulmonary dysplasia (BPD), a devastating lung disease in premature infants, the mechanisms of which are not fully characterized. Here we report that the triggering receptor expressed on myeloid cells 1 (TREM-1) is upregulated in hyperoxia exposed neonatal mice lungs as well as in human neonatal lungs with respiratory distress syndrome (RDS) and BPD as an adaptive response to survive hyperoxia. Inhibition of TREM-1 function using siRNA approach or deletion of TREM-1 gene in mice showed increased alveolar damage and mortality of...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Syed, M. A., Shah, D., Bhandari, V. Tags: Lung and airway developmental biology Source Type: research
Dysregulated mitochondrial integrity associated with lamin B1 reduction is involved in cellular senescence progression in COPD pathogenesis
Conclusion: These findings suggest the involvement of mTOR-mediated dysregulated mitochondrial integrity in cellular senescence progression during lamin B1 reduction in COPD pathogenesis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Saito, N., Araya, J., Ito, S., Hosaka, Y., Kadota, T., Yoshida, M., Tsubouchi, K., Ichikawa, A., Kurita, Y., Kobayashi, K., Minagawa, S., Hara, H., Utsumi, H., Yanagisawa, H., Hashimoto, M., Wakui, H., Ishikawa, T., Numata, T., Kaneko, Y., Nakayama, K., K Tags: Airway Cell Biology and Immunopathology Source Type: research
Analyzing the role of proteasome activator 200 (PA200) in lung cancer
The proteasome system is the main cellular protein degradation machinery and acts as a key regulator of cellular growth, survival and signaling. Tumor cells are highly dependent on its function and the proteasome has been shown to be activated in colon or breast cancer. Its regulation in lung cancer, however, is largely unknown. We here investigated the role of the proteasome activator PA200 in lung cancer to determine its so far unknown regulation in disease and to better characterize proteasome regulation in lung cancer.The specificity of PA200 antibodies was first validated by siRNA-mediated silencing of PA200 in A549 a...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Welk, V., Meul, T., Lukas, C., Bölükbas, D., Koch, I., Lindner, M., Meiners, S. Tags: Lung Cancer Source Type: research
Late Breaking Abstract - NGF induces pulmonary arterial hyperreactivity through increased connexin-43 expression: potential role in pulmonary hypertension
Conclusions: Our results show that NGF increases Cx43 expression in human and rat PA through a TrkA/PI3K/ERK-dependent signalling pathway. This mechanism contributes to NGF-induced PA hyperreactivity and may thus participate in PH pathophysiology.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Douard, M., Robillard, P., Deweirdt, J., Baudrimont, I., Dubois, M., Marthan, R., Savineau, J.-P., Muller, B., Guibert, C., Freund-Michel, V. Tags: Pulmonary hypertension Source Type: research
Late Breaking Abstract - Chronic Hypoxia Promotes Pulmonary Venous Smooth Muscle Cells Proliferation by Upregulating Calcium Sensing Receptor
Conclusions: CaSR mediating excessive PVSMC proliferation is a new pathogenic mechanism involved in the initiation and progression of hypoxic PVSMC proliferation.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Peng, G., Li, S., Hong, W., Xu, J., Liu, R., Li, B., Ran, P. Tags: Pulmonary hypertension Source Type: research
The BRD4-PLK1 Axis Drives Vascular Remodeling in PAH
Conclusion: We demonstrate that the BRD4/PLK1 axis is increased in human PAH and represents a promising therapeutic target.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Boucherat, O., Tremblay, E., Martineau, S., Jahagirdar, R., Kulikowski, E., Provencher, S., Bonnet, S. Tags: Pulmonary hypertension Source Type: research
Cigarette smoke induces mitochondrial dysfunction via PKCd-p66Shc signaling pathway in human bronchial epithelial cells
Conclusions: These data suggest that PKC-p66Shc pathway may be involved in the pathogenesis of COPD.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Zhang, M., Li, Y., Tang, J., Zhang, J., Yang, X., Shan, H., Zhang, Q. Tags: Airway Cell Biology and Immunopathology Source Type: research
