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Utility of the provocation coupled with the drug reintroduction test in the diagnosis of a hypersensitivity reaction to fixed-dose combination (FDC) of anti-TB drugs
Conclusion: Diagnosis tests for a hypersensitivity reaction to FDC of anti-TB drugs are codified. In the absence of drug atopy tests, provocation coupled with reintroduction test find are usefull for the diagnosis of the incriminated molecule.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Sana, A., Asma, O., Rahma, B. J., Wafa, B., Asma, K., Amani, K., Imen, G., Ahmed, A., Abdelaziz, H. Tags: 10.02 - Tuberculosis and non-tuberculous mycobacterial diseases Source Type: research

Association of tuberculosis infection with asthma in a european multinational cohort
Conclusion: Our study showed that TB infection was associated with asthma, in particular non-allergic asthma. Longitudinal analyses are needed to further explore these results.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Gyawali, S., Lopez Cervantes, J. P., Mustafa, T., Svanes, C., Shigdel, R. Tags: 06.01 - Epidemiology Source Type: research

Asthma and COVID-19 risk: a systematic review and meta-analysis
Background Individual case series and cohort studies have reported conflicting results in people with asthma on the vulnerability to and risk of mortality from coronavirus disease 2019 (COVID-19). Research question Are people with asthma at a higher risk of being infected or hospitalised or poorer clinical outcomes from COVID-19? Methods A systematic review and meta-analysis based on five main databases including the World Health Organization COVID-19 database between 1 December 2019 and 11 July 2021 on studies with a control (non-asthma) group was conducted. Prevalence and risk ratios were pooled using Sidik–Jonkm...
Source: European Respiratory Journal - March 31, 2022 Category: Respiratory Medicine Authors: Sunjaya, A. P., Allida, S. M., Di Tanna, G. L., Jenkins, C. R. Tags: Asthma and allergy, Respiratory infections and tuberculosis Original Articles: Asthma and infection Source Type: research

Does parental tuberculosis infection increase the risk of asthma in their offspring? A Norwegian registry-based study
Conclusions: Parental tuberculosis infection in childhood was associated with higher risk of asthma in their future offspring. We speculate that tuberculosis may have profound impact that may be transferred to offspring, the nature of such impact needs further study.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Lopez-Cervantes, J. P., Shigdel, R., Mustafa, T., Svanes, C. Tags: Allergy and immunology Source Type: research

The impact of COVID-19 on patients with asthma
Conclusion Patients with asthma and COVID-19 were older and at increased risk due to comorbidity-related factors. ICS and biologics are generally safe and may be associated with a protective effect against severe COVID-19 infection.
Source: European Respiratory Journal - March 4, 2021 Category: Respiratory Medicine Authors: Izquierdo, J. L., Almonacid, C., Gonzalez, Y., Del Rio-Bermudez, C., Ancochea, J., Cardenas, R., Lumbreras, S., Soriano, J. B. Tags: Respiratory infections and tuberculosis Original Articles: Pulmonary infections Source Type: research

Clinico-radiological and serological features in Allergic bronchopulmonary aspergillosis
Conclusions: There is a high prevalence of ABPA in asthmatic patients presenting at our hospital. The disease entity is still underrecognized in India, the vast majority of patients have bronchiectasis at presentation, and almost half are initially misdiagnosed as having pulmonary tuberculosis. There is a need to redefine the diagnostic criteria of ABPA and to develop a gold standard diagnostic test. This study places emphasis on using IgE levels specific for Aspergillus fumigatus as a screening test for ABPA.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Prasanth, P. Tags: Allergy and immunology Source Type: research

Bronchial inflammation, respiratory symptoms and lung function in patients who finished treatment for pulmonary tuberculosis: is it the beginning of a new disease?
Conclusion: This study suggests the existence of different celullar patterns once the treatment has finished and supports the basis of a treatment hypothesis.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Palma, I., Castro Zorrilla, L., Resguardo, A., Martinez, D., Troncoso, D., Cruz, V., Vina, J., Alves, L., Natiello, M., Estevan, R., Lazari, N., Medin, M. I., Inwentarz, S., Videla, A., Palmero, D. Tags: Allergy and immunology Source Type: research

Etiology of bronchiectasis in Finland
Conclusions: Asthma was associated to bronchiectasis in 76% of the patients but it was estimated as etiology in only every fifth patient. However, retrospectively it is difficult to exclude asthma as a background cause in many cases with recurrent asthma like symptoms and respiratory infections. Nevertheless, in one fifth of the patients no identifiable cause was found. None of the patients had had tuberculosis. Lung function test results were well preserved and in 66% bronchiectasis was restricted to one-three lobes.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Mäntylä, J., Mazur, W., Viinanen, A., Purokivi, M., Kauppi, P. Tags: Epidemiology Source Type: research

Risk score of drug-induced liver injury among new tuberculosis patients
Conclusion: a questionnaire was developed to assess the DILI risk before ATT starting for targeted prevention and monitoring of DILI among new TB patients.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Ivanova, D., Borisov, S. Tags: Tuberculosis Source Type: research

Manifestations of hypersensitivity to anti-tuberculosis drugs
Conclusion: ATD can induce allergic reaction type I to IV, occurring preferably in the first two months of treatment. The female prédominance has been described for EPT. Monitoring of this patients is necessary. The responsable ATD schould be identifed to allow, if possible, a resumption of ATD.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Benbetka, Y., Souilah, S., Fissah, A. Tags: Tuberculosis Source Type: research

Safety profile of a novel peptide, PIN201104, with potential to act as a disease modifying, broad spectrum treatment for asthma
Conclusion: From these studies, 104 does not show potential to induce significant safety concerns going into clinical development.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Watson, J., Federici-Canova, D., Cooper, N., Burgess, C. Tags: Allergy and immunology Source Type: research

Tolerance and side effects of second line anti tubercular drugs
Conclusion: Second line anti TB drugs are associated with multiple side effects. Comorbidities major intolerance risk. Early management of intolerance is necessary to improve TB prognosis.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Agrebi, S., Ben Saad, S., Habouria, C., Daghfous, H., Tritar, F. Tags: Tuberculosis Source Type: research

Rifamycin induced leukocytoclastic vasculitis. A rare side-effect of anti-tuberculous chemotherapy
We describe a case of leucocytoclastic vasculitis (LCV) caused by rifamycins.A 53 year old female presented with cough, night sweats and upper lobe nodules. Bronchial-alveolar lavage confirmed fully sensitive mycobacterium tuberculosis (TB).She commenced treatment with rifampicin, isoniazid, ethambutol and pyrizinazmide. At 4 weeks she developed an extensive purpuric rash, malaise and joint aches. There was no evidence of other infections or connective tissue disorders on extensive screening. Her inflammatory markers were elevated. A punch biopsy of her shin demonstrated leukocytoclastic vasculitis of the superficial dermi...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Ewence, A., Dodd, J., Tewari, A., Akhras, V., Aul, R. Tags: 10.2 Tuberculosis Source Type: research

Eosinophilia and predominant Th2 immune responses are rarely evident in disseminated tuberculosis
Conclusion: We could find no evidence of frequent asthma or heightened Th2 immunity (high blood eosinophils) in disseminated TB. It is possible that measuring blood counts at time of presentation is too late to detect any eosinophilia present earlier when they first acquired TB and failed to mount an early effective immune response. The eosinopaenia in these patients may reflect Th1 immune responses suppressing Th2 responses, and there is limited evidence that BCG vaccination may be able to suppress asthmatic inflammation.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Pfeffer, P., Burman, M., Milton, V., Naidu, V., Vaghela, D., Kunst, H. Tags: 10.2 Tuberculosis Source Type: research

Antituberculosis fixed multi-dose combination and single drug therapy in active tuberculosis: What is about drug hypersensitivity reactions?
CONCLUSION: Adverse drug reaction anti-TB drugs whatever form is not an uncommon. Hematologic effects significantly higher in patients treated with FDCs and Significant difference in doses of Isoniazid and Rifampicin can be the reason of these.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Majdoub, S., Daghfouss, H., Ben Saad, S., Ben Tkhayat, A., Tritar, F. Tags: 5.3 Allergy and Immunology Source Type: research

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