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Specialty: Biology
Source: Life Sciences
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Total 146 results found since Jan 2013.
Role of canonical transient receptor potential channel-3 in acetylcholine-induced mouse airway smooth muscle cell proliferation
Publication date: Available online 9 August 2017 Source:Life Sciences Author(s): Xiao-Xu Chen, Jia-Hua Zhang, Bin-Hua Pan, Hui-Li Ren, Xiu-Ling Feng, Jia-Ling Wang, Jun-Hua Xiao Aims Canonical transient receptor potential channel-3 (TRPC3)-encoded Ca2+-permeable nonselective cation channel (NSCC) has been proven to be an important native constitutively active channel in airway smooth muscle cell (ASMC), which plays significant roles in physiological and pathological conditions by controlling Ca2+ homeostasis in ASMC. Acetylcholine (ACh) is generally accepted as a contractile parasympathetic neurotransmitter in the airway....
Source: Life Sciences - August 9, 2017 Category: Biology Source Type: research
Effects of lentivirus-mediated silencing of Periostin on tumor microenvironment and bone metastasis via the integrin-signaling pathway in lung cancer
Publication date: Available online 7 June 2017 Source:Life Sciences Author(s): Jing Che, Wen-Zhuang Shen, Yu Deng, Yu-Hong Dai, Yong-De Liao, Xiang-Lin Yuan, Peng Zhang The study aims to investigate the effects of Periostin gene silencing on tumor microenvironment and bone metastasis via the integrin-signaling pathway in lung cancer (LC). LC patients were divided into bone metastasis and non-bone metastasis groups; Healthy volunteers were selected as normal group. ELISA was performed to detect serum Periostin levels and plasma calcium ion concentration. SBC-5 cells were assigned into blank group (without transfection), ne...
Source: Life Sciences - June 8, 2017 Category: Biology Source Type: research
7-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells
Publication date: Available online 8 May 2017 Source:Life Sciences Author(s): En-Xia Wang, Bo-Yang Zou, Lei Shi, Lin-Ying Du, Yan-Yan Zhu, Ya-Meng Jiang, Xiao-Dong Ma, Xiao-Hui Kang, Chang-Yuan Wang, Yu-Hong Zhen, Li-Dan Sun Aims To investigate the antitumor effects of 7-O-geranylquercetin (GQ), a novel O-alkylated derivative of quercetin, against non-small cell lung cancer (NSCLC) cell lines A549 and NCI-H1975 and the corresponding mechanisms. Main methods Cell viability was assessed using MTT assay. The expression of proteins involved in apoptosis and autophagy was measured using western blotting. Besides, apoptosis was...
Source: Life Sciences - May 9, 2017 Category: Biology Source Type: research
1,25-Dihydroxyvitamin D3 suppresses gastric cancer cell growth through VDR- and mutant p53-mediated induction of p21
Publication date: Available online 29 April 2017 Source:Life Sciences Author(s): Mingxing Li, Longfei Li, Lin Zhang, Wei Hu, Jing Shen, Zhangang Xiao, Xu Wu, Franky Leung Chan, Chi Hin Cho Aims Previous studies have indicated that vitamin D deficiency correlates with cancer risk and vitamin D potentiates antitumor effects in a variety of cancers. The antitumor effect of vitamin D on gastric cancer was rarely studied. We aimed to investigate the antitumor effect of vitamin D on gastric cancer and underlying mechanisms. Main methods We investigated the antitumor activity of the active form of vitamin D, 1α,25-dihydroxyvita...
Source: Life Sciences - April 30, 2017 Category: Biology Source Type: research
The lipid moiety 7-ketocholesteryl-9-carboxynonanoate mediates binding interaction of oxLDL to LOX-1 and upregulates ABCA1 expression through PPAR γ
Publication date: Available online 2 April 2017 Source:Life Sciences Author(s): Jingda Li, Zhilong Xiu, Renjun Wang, Chengjie Yu, Yan Chi, Jianzhong Qin, Changzhen Fu, Eiji Matsuura, Qingping Liu Aim Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), a specific membrane receptor for oxidized low-density lipoprotein (oxLDL), plays a crucial role in atherosclerosis progression. The aim of this study was to elucidate the role of 7-ketocholesteryl-9-carboxynonanoate (oxLig-1), a lipid component of oxLDL, in the binding of oxLDL to LOX-1 and to determine whether oxLig-1 binding to LOX-1 is involved in the upregul...
Source: Life Sciences - April 2, 2017 Category: Biology Source Type: research
Toll-like receptor 9 mediates paraquat-induced acute lung injury: An in vitro and in vivo study
This study aimed to investigate the role of Toll-like receptor 9 in paraquat-induced acute lung injury (ALI). Main methods For in vivo study,C57BL mice were randomly assigned into the vehicle control group, paraquat group, paraquat + antagonist (ODN2088) group, and antagonist (ODN2088) group (n =24 per group). After paraquat 30mg/kg ip for 2, 24 and 48h, serum samples and lung tissues were collected to evaluate ALI and TLR9 signaling. As for in vitro research A549 cells were randomly divided into the control group, paraquat group, paraquat + TLR9 siRNA group, and TLR9 siRNA group. After paraquat treatment for 24h, the cell...
Source: Life Sciences - March 29, 2017 Category: Biology Source Type: research
SIRT1 regulates lipopolysaccharide-induced CD40 expression in renal medullary collecting duct cells by suppressing the TLR4-NF- κB signaling pathway
Publication date: Available online 1 December 2016 Source:Life Sciences Author(s): Qin-qin Lin, Yuan-wen Geng, Zhong-wei Jiang, Zhen-jun Tian Aims Recent evidence indicates that sirtuin1 (SIRT1), a NAD+-dependent deacetylase, exerts a protective effect against inflammatory kidney injury by suppressing pro-inflammatory cytokines production. The co-stimulatory molecule, CD40, is expressed in a variety of inflammatory diseases in the kidney. Here, we aimed to investigate the potential effect of SIRT1 on CD40 expression induced by lipopolysaccharide (LPS) and to disclose the underlying mechanisms in renal inner medullary coll...
Source: Life Sciences - November 30, 2016 Category: Biology Source Type: research
Suppression of Kv1.5 protects against endothelial apoptosis induced by palmitate and in type 2 diabetes mice
Publication date: 1 January 2017 Source:Life Sciences, Volume 168 Author(s): Jie-Yi Du, Feng Yuan, Li-Yan Zhao, Jie Zhu, Yun-Ying Huang, Gen-Shui Zhang, Yi Wei, Yun Liu, Quan Yi, Yong-sheng Tu, Xiao Zhong, Fang-Yun Sun, Hong-Shuo Sun, Yong-Yuan Guan, Wen-Liang Chen, Guan-Lei Wang Aims Palmitate, a common saturated free fatty acid, induces endothelial apoptosis in vitro in culture endothelial cells and in vivo in type 2 diabetes mellitus (T2DM) patients. The present study aimed to investigate whether Kv1.5 regulates palmitate-induced endothelial apoptosis and endothelial dysfunction in T2DM. Main methods In vitro experimen...
Source: Life Sciences - November 22, 2016 Category: Biology Source Type: research
Cardioprotective effects of monocyte locomotion inhibitory factor on myocardial ischemic injury by targeting vimentin
In this study, we evaluated the effect of MLIF on myocardial ischemia. The myocardial ischemia reperfusion (I/R) model was established by ligation of the left anterior descending branch (LAD) using 8–0 silk suture for 30min followed by 3h reperfusion in mice. After sacrifice, the serum concentrations of cardiac troponin I (cTnI), creatine kinase (CK), lactate dehydrogenase (LDH) as well as the heart infarct size were measured. An in vitro myocardial ischemia model was established by oxygen-glucose deprivation (OGD) induced H9c2 cell apoptosis. The apoptotic cell rate was examined by flow cytometry assay, and the expressi...
Source: Life Sciences - October 28, 2016 Category: Biology Source Type: research
Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle
Conclusion: Nox4 activation in VSMCs contributes to actin depolymerization after hypoxia, which could be the underlying mechanism for myogenic-tone impairment following ischemia/reperfusion.
Source: Life Sciences - August 21, 2016 Category: Biology Source Type: research
Association of Notch4 with metastasis in human oral squamous cell carcinoma
This study therefore investigates (1) the expression of Notch4 and its downstream target myelin associated glycoprotein (MAG) in tissue samples representative of different stages of OSCC with varied clinicopathological features and (2) the possible involvement of Notch4 in the proliferation and migration of OSCC cells. Main methods Sixty patients reported positive for OSCC were obtained along with the clinicopathological parameters and we performed immunohistochemistry, western blotting and RT-PCR for Notch4 and MAG expression. Further, the metastatic role of Notch4 was analyzed in the HSC-3 cell line by cell proliferatio...
Source: Life Sciences - May 16, 2016 Category: Biology Source Type: research
TLR4 siRNA inhibits proliferation and invasion in colorectal cancer cells by downregulating ACAT1 expression
Publication date: Available online 10 May 2016 Source:Life Sciences Author(s): Kai Ye, Yiyang Wu, Yafeng Sun, Jian'an Lin, Jianhua Xu Aims Toll-like receptor 4 (TLR4) is involved in tumor development. Numerous studies have confirmed that TLR4 mediates processes in tumorigenesis, for example, inflammation, proliferation and invasion. However, the effects of TLR4 on colorectal cancer development have not been fully elucidated. The present study aimed to evaluate the effects and mechanisms of TLR4 on colorectal cancer development. Main methods The expression of TLR4 and Acyl coenzyme A cholesterol acyltransferase 1 (A...
Source: Life Sciences - May 10, 2016 Category: Biology Source Type: research
Lycopene inhibits ICAM-1 expression and NF-κB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells
Publication date: Available online 4 May 2016 Source:Life Sciences Author(s): Po-Min Yang, Zhi-Zhen Wu, Yu-Qi Zhang, Being-Sun Wung Aims Age-related macular degeneration (AMD) is one of the most common diseases leading to blindness in elderly people. The progression of AMD may be prevented through anti-inflammation and antioxidation in retinal pigment epithelial (RPE) cells. Lycopene, a carotenoid, has been shown to possess both antioxidative and anti-inflammatory properties. This research was conducted to detail the mechanisms of these effects of lycopene-treated RPE cells. Main methods We exposed ARPE-19 cells to ...
Source: Life Sciences - May 4, 2016 Category: Biology Source Type: research
Acquired expression of osteopontin selectively promotes enrichment of leukemia stem cells through AKT/mTOR/PTEN/β-catenin pathways in AML cells
Publication date: 1 May 2016 Source:Life Sciences, Volume 152 Author(s): Saeed Mohammadi, Seyed H. Ghaffari, Mojgan Shaiegan, Mahin Nikougoftar Zarif, Mohsen Nikbakht, Shiva Akbari Birgani, Kamran Alimoghadam, Ardeshir Ghavamzadeh Aims Acute myeloid leukemia (AML) initiation and progression have been attributed to subpopulations of self-renewing leukemia stem cells (LSCs), which contribute to progression, recurrence and therapeutic resistance in leukemia. Osteopontin (OPN) plays an important role in promoting survival and drug resistance in LSCs. The aim of this study was to explore OPN roles in modulating curcum...
Source: Life Sciences - May 2, 2016 Category: Biology Source Type: research
A novel bisindole-PBD conjugate inhibits angiogenesis by regulating STAT3 and VEGF in breast cancer cells
Publication date: Available online 12 March 2016 Source:Life Sciences Author(s): Pranjal Sarma, M. Janaki Ramaiah, Dhananjaya Pal, Utpal Bhadra, Manika Pal Bhadra Aims Breast cancer is highly resistant to chemotherapeutic approach and hence, alternative strategies have been developed to fight against this heterogeneous group of disease. In particular, many studies have demonstrated about various drugs for the treatment of breast cancer. In our study, we assessed the anti-angiogenenic activities of Bisindole-PBD (5b) in MCF-7 and MDA-MB-231 cell lines. Main methods In vitro Endothelial Cell (HUVEC) Tube Formation As...
Source: Life Sciences - March 12, 2016 Category: Biology Source Type: research
