• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Amentoflavone inhibits tumorsphere formation by regulating the Hedgehog/Gli1 signaling pathway in SUM159 breast cancer stem cells
This study aimed to investigate the effects of amentoflavone, a natural compound identified from Chamaecyparis obtusa, on stemness of basal-like SUM159 breast CSCs, and its underlying mechanism of action. We found that amentoflavone suppressed tumorsphere formation and regulated the expression of the stem cell markers CD44, CD24, and ALDH1 in a dose dependent manner, and inhibited Hedgehog (Hh) signaling by down-regulating Smo, Gli1, OCT4, and NANOG. Knock-down of Gli1 by siRNA significantly affected the expression of CD44, CD24, ALDH1, OCT4, and NANOG, and reduced tumorsphere formation efficiency in SUM159 breast CSCs. Ou...
Source: Journal of Functional Foods - August 7, 2019 Category: Nutrition Source Type: research

Flavonoids from Livistona chinensis fruit ameliorates LPS/D-GalN-induced acute liver injury by inhibiting oxidative stress and inflammation
This study investigated the hepatoprotective effect and mechanism of flavonoids from Livistona chinensis fruit (FLCF). Mice received FLCF pre-treatment for 7 days and induced liver injury with LPS+D-GalN. RAW264.7 cells were triggered inflammation by LPS and received FLCF for 24 h. The result showed that FLCF ameliorated the liver pathology in mice, decreased the levels of AST, ALT, MDA, but increased SOD and GSH. Moreover, FLCF inhibited TLR4/NF-κB signaling, while activated Nrf2/HO-1 signaling in LPS+D-GalN mice. These effects were consistent with the in vitro data revealing that FLCF suppressed TLR4/NF-κB signalin...
Source: Journal of Functional Foods - July 18, 2019 Category: Nutrition Source Type: research

Gallotannin derivatives from mango (Mangifera indica L.) suppress adipogenesis and increase thermogenesis in 3T3-L1 adipocytes in part through the AMPK pathway
In this study, 3T3-L1 preadipocytes were differentiated into adipocytes and treated with mango polyphenols (MG), or pyrogallol (PG) for 6 days. The anti-adipogenic activity of PG was demonstrated by reduced number of lipid droplets and expressions of adipogenic markers, such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). In mature adipocytes, PG promoted adipocyte browning and increased the expressions of uncoupling protein 1 (UCP1) and sirtuin 1 (Sirt1). Knockdown of AMP-activated protein kinase (AMPK) α1 with siRNA partially abolished the effect of PG on adip...
Source: Journal of Functional Foods - May 4, 2018 Category: Nutrition Source Type: research

Serine prevents LPS-induced intestinal inflammation and barrier damage via p53-dependent glutathione synthesis and AMPK activation
Publication date: December 2017 Source:Journal of Functional Foods, Volume 39 Author(s): Xihong Zhou, Yumei Zhang, Liuqin He, Dan Wan, Gang Liu, Xin Wu, Yulong Yin The role of serine in metabolic processes has recently attracted much attention as it could be used for the biosynthesis of purine, sphingolipids, and glutathione. The present study was conducted to investigate the effects of serine on LPS-induced intestinal inflammation and barrier dysfunction. The results showed that pretreatment with serine prevented the LPS-induced inflammatory response and oxidative stress both in vivo and in vitro. Moreover, serine mainta...
Source: Journal of Functional Foods - November 3, 2017 Category: Nutrition Source Type: research

Transport of soybean protein-derived antihypertensive peptide LSW across Caco-2 monolayers
In conclusion, antihypertensive tripeptide LSW was transported intact across Caco-2 monolayers by paracellular diffusion via TJ and PepT1 pathway, but not by transcytosis pathway.
Source: Journal of Functional Foods - October 19, 2017 Category: Nutrition Source Type: research

Quercetin attenuates tau hyperphosphorylation and improves cognitive disorder via suppression of ER stress in a manner dependent on AMPK pathway
Publication date: April 2016 Source:Journal of Functional Foods, Volume 22 Author(s): Junjun Chen, Xueyang Deng, Ning Liu, Min Li, Baolin Liu, Qiang Fu, Rong Qu, Shiping Ma Quercetin, a natural flavonoid abundantly found in onions, apples, tea, berries, cauliflower, and red wine, has been demonstrated to exert beneficial effect on Alzheimer's disease. We aimed to investigate its AMPK activity on hyperphosphorylation of tau and explore the underlying mechanism associated with Endoplasmic reticulum (ER) stress. Quercetin and quercetin-3-O-glucuronide suppressed ER stress with decreased phosphorylation of IRE1α and...
Source: Journal of Functional Foods - February 24, 2016 Category: Nutrition Source Type: research

Icaritin protects against oxidative stress-induced injury in cardiac H9c2 cells via Akt/Nrf2/HO-1 and calcium signalling pathways
Publication date: October 2015 Source:Journal of Functional Foods, Volume 18, Part A Author(s): Si Wan Lei, Guozhen Cui, George Pak Heng Leung, Sharon Chui Wah Luk, Maggie Pui Man Hoi, Liang Wang, Gail B. Mahady, Simon Ming Yuen Lee Icaritin, a prenylflavonoid isolated from Herbal Epimedii, is well known for its osteoplastic and anti-tumour activities. Here, we examined the cardioprotective actions of icaritin on cardiac H9c2 cells under oxidative stress conditions induced by treatment with tert-butylhydroperoxide (t-BHP). Icaritin at a concentration range between 1 and 4 µM effectively increased cell viabilit...
Source: Journal of Functional Foods - July 30, 2015 Category: Nutrition Source Type: research

Zyflamend, a polyherbal mixture, inhibits lipogenesis and mTORC1 signalling via activation of AMPK
The objective in this study was to determine if the antiproliferative effects are mediated, in part, through the activation of AMPK signalling and inhibition of its downstream targets, lipogenesis and mTORC1 complex. By increasing the phosphorylation of AMPK in CWR22Rv1 and PC3 prostate cancer cell lines, Zyflamend decreased de novo lipid biosynthesis by decreasing the activity of acetyl-CoA carboxylase and the expressions of fatty acid synthase and SREBP-1c, with a concomitant up regulation of fatty acid oxidation. In addition, via AMPK, Zyflamend inhibited the activity of mTORC1 complex by directly phosphorylating raptor...
Source: Journal of Functional Foods - July 25, 2015 Category: Nutrition Source Type: research

Ursolic acid protects hepatocytes against lipotoxicity through activating autophagy via an AMPK pathway
Publication date: August 2015 Source:Journal of Functional Foods, Volume 17 Author(s): Fanyu Meng , Hua Ning , Zongxiang Sun , Fangfang Huang , Yanchuan Li , Xia Chu , Huimin Lu , Changhao Sun , Songtao Li Ursolic acid is a naturally occurring pentacyclic triterpenoid in many plants, such as medicinal herbs and food, and was previously found to be an effective phytochemical that protected against high-fat diet-induced hepatic steatosis and liver injury. However, the molecular mechanisms are not fully determined. The present study examined the protective role of ursolic acid against saturated fatty acid-induced lipotoxici...
Source: Journal of Functional Foods - June 7, 2015 Category: Nutrition Source Type: research