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The Matrix Metalloproteinase ‐13 Inhibitor Poricoic Acid ZI Ameliorates Renal Fibrosis by Mitigating Epithelial‐Mesenchymal Transition
ConclusionsThe findings indicate that as a specific MMP ‐13 inhibitor, PZI attenuates EMT and renal fibrosis. Therefore, the MMP‐13 inhibitor PZI could be a novel therapeutic candidate for limiting EMT and renal fibrosis.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - March 28, 2019 Category: Food Science Authors: Lin Chen, Gang Cao, Ming Wang, Ya ‐Long Feng, Dan‐Qian Chen, Nosratola D. Vaziri, Shougang Zhuang, Ying‐Yong Zhao Tags: Research Article Source Type: research

Luteolin Ameliorates Testis Injury and Blood ‐Testis Barrier Disruption through the Nrf2 Signaling Pathway and by Up‐Regulating Cx43
Conclusion: Luteolin was identified as a novel active ingredient that contributed to the protective activity in testicular damage through activating the Nrf2 signaling pathway and by up ‐regulating Cx43.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - March 28, 2019 Category: Food Science Authors: Bo Ma, Jie Zhang, Zhiming Zhu, Ang Zhao, Yanfen Zhou, Hanjie Ying, Qi Zhang Tags: Research Article Source Type: research

Increased Dynamin ‐Related Protein 1–Dependent Mitochondrial Fission Contributes to High‐Fat‐Diet‐Induced Cardiac Dysfunction and Insulin Resistance by Elevating Tafazzin in Mouse Hearts
ConclusionIn HF ‐diet‐fed mouse hearts, increased tafazzin contributes to insulin resistance via mediating Drp‐1 translocation to the mitochondria, and a small non‐coding RNA, miR‐125b‐5p, at least partially regulates this signaling pathway and alleviates insulin resistance.
Source: Molecular Nutrition and Food Research - January 18, 2019 Category: Food Science Authors: Wenguang Chang, Dandan Xiao, Xiang Ao, Mengyang Li, Tao Xu, Jianxun Wang Tags: Research Article Source Type: research

Increased Dynamin ‐Related Protein 1‐Dependent Mitochondrial Fission Contributes to High‐Fat Diet‐Induced Cardiac Dysfunction and Insulin Resistance by Elevating Tafazzin in Mouse Hearts
ConclusionIn high ‐fat diet‐fed mouse hearts, increased tafazzin contributes to insulin resistance via mediating Drp‐1 translocation to the mitochondria, and a small non‐coding RNA, miR‐125b‐5p, at least partially regulates this signalling pathway and alleviates insulin resistance.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 10, 2019 Category: Food Science Authors: Wenguang Chang, Dandan Xiao, Xiang Ao, Mengyang Li, Tao Xu, Jianxun Wang Tags: Research Article Source Type: research

The anti ‐inflammatory effects of Morin hydrate in atherosclerosis is associated with autophagy induction through cAMP signaling
Conclusion: Our results suggest that anti‐AS and anti‐inflammatory effects of MO are largely associated with its induction of autophagy through stimulation of cAMP‐PKA‐AMPK‐SIRT1 signaling pathway.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - April 1, 2017 Category: Food Science Authors: Yue Zhou, Zhan ‐Qi Cao, Hong‐Yuan Wang, Yan‐Na Cheng, Lu‐Gang Yu, Xin‐Ke Zhang, Yan Sun, Xiu‐Li Guo Tags: Research Article Source Type: research

Fructose down ‐regulates miR‐330 to induce renal inflammatory response and insulin signaling impairment: Attenuation by morin
Conclusion: These findings suggest that morin protects against fructose‐induced kidney insulin signaling impairment by up‐regulating miR‐330 to reduce inflammatory response. Morin may be a potential therapeutic agent for the treatment of kidney injury associated with fructose‐induced inflammation and insulin signaling impairment.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 31, 2017 Category: Food Science Authors: Ting ‐Ting Gu, Lin Song, Tian‐Yu Chen, Xin Wang, Xiao‐Juan Zhao, Xiao‐Qin Ding, Yan‐Zi Yang, Ying Pan, Dong‐Mei Zhang, Ling‐Dong Kong Tags: Research Article Source Type: research

Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1/ChREBP and SIRT1/p66shc pathways in rats
Conclusion: CA exerted protective effects against alcoholic liver injury by activating the SIRT1/ChREBP and SIRT1/p66shc pathways, which are related to the anti‐steatosis, anti‐oxidant and anti‐apoptosis effects.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - March 31, 2016 Category: Food Science Authors: Lili Gao, Wen Shan, Wenjing Zeng, Yan Hu, Guangzhi Wang, Xiaofeng Tian, Ning Zhang, Xue Shi, Yan Zhao, Chunchun Ding, Feng Zhang, Kexin Liu, Jihong Yao Tags: Research Article Source Type: research

Curcumin protects against fructose‐induced podocyte insulin signaling impairment through upregulation of miR‐206
ConclusionCurcumin is suggested to activate miR‐206 expression to downregulate PTP1B, and then improve insulin signaling, protect against fructose‐induced glomerular podocyte injury, and proteinuria, which may provide new evidence regarding curcumin's effects on fructose‐associated podocyte injury.
Source: Molecular Nutrition and Food Research - October 15, 2015 Category: Food Science Authors: Xiao‐Qin Ding, Ting‐Ting Gu, Wei Wang, Lin Song, Tian‐Yu Chen, Qiao‐Chu Xue, Fan Zhou, Jian‐Mei Li, Ling‐Dong Kong Tags: Research Article Source Type: research

Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway
Conclusions: RSV improved hepatic steatosis partially by inducing autophagy in vitro and in vivo, via the cAMP‐PRKA‐AMPK‐SIRT1 signaling pathway, which provides new evidence regarding RSV's effects on NAFLD treatmentThis article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - May 5, 2015 Category: Food Science Authors: Yong Zhang, Ming‐liang Chen, Yong Zhou, Long Yi, Yan‐xiang Gao, Li Ran, Shi‐hui Chen, Ting Zhang, Xi Zhou, Dan Zou, Bin Wu, Ying Wu, Hui Chang, Jun‐dong Zhu, Qian‐yong Zhang, Man‐tian Mi Tags: Research Article Source Type: research

Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function
Conclusion: Nobiletin exerted anti‐inflammatory effects in TNBS‐induced colitis through the down‐regulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX‐2) expression. Nobiletin restored barrier function, which had been damaged after TNBS administration, through the inhibition of the Akt–NF‐κB–MLCK pathway.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - February 1, 2015 Category: Food Science Authors: Yongjian Xiong, Dapeng Chen, Changchun Yu, Bochao Lv, Jinyong Peng, Jingyu Wang, Yuan Lin Tags: Research Article Source Type: research

Sulforaphane suppresses cardiac hypertrophy by inhibiting GATA4/GATA6 expression and MAPK signaling pathways
Conclusion: These results suggest that sulforaphane has the potential to prevent cardiac hypertrophy by down‐regulating GATA4/6 and MAPK signaling pathways.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - October 1, 2014 Category: Food Science Authors: Hae Jin Kee, Gwi Ran Kim, In Kyeom Kim, Myung Ho Jeong Tags: Research Article Source Type: research

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