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Source: Clinical and Translational Allergy
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Total 373 results found since Jan 2013.
Differences in medication adherence are associated with beliefs about medicines in asthma and COPD
This study refers to the “necessity-concerns framework” and examines the associations between beliefs about medicines and self-reported medication adherence in people with chronic obstructive lung disease. 402 patients (196 with asthma, 206 with COPD) participated in the study and completed a questionnaire comprising th e “Beliefs about Medicines-Questionnaire” (BMQ) and the “Medication Adherence Report Scale” (MARS). Multivariable logistic regression analyses with the BMQ-subscales as explanatory and the dichotomized MARS-score as dependent variable were computed for the asthma and the COPD sample, respect ive...
Source: Clinical and Translational Allergy - November 10, 2017 Category: Allergy & Immunology Source Type: research
Comparison of atopy patch testing to skin prick testing for diagnosing mite-induced atopic dermatitis: a systematic review and meta-analysis
ConclusionsOur analysis indicates that APT is a useful tool in the screening of mite-induced AD, although this conclusion must be interpreted cautiously due to high heterogeneity among the included studies.
Source: Clinical and Translational Allergy - November 29, 2017 Category: Allergy & Immunology Source Type: research
Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis
ConclusionsThe prevalence of coexisting allergic rhinitis and asthma shows a clear male predominance in childhood and seems to switch to a female predominance in adolescents. This switch was less pronounced for allergic rhinitis only.
Source: Clinical and Translational Allergy - December 5, 2017 Category: Allergy & Immunology Source Type: research
How to manage anaphylaxis in primary care
AbstractAnaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction characterized by rapidly developing airway and/or circulation problems. It presents with very different combinations of symptoms and apparently mild signs and can progress to fatal anaphylactic shock unpredictably. The difficulty in recognizing anaphylaxis is due, in part, to the variability of diagnostic criteria, which in turn leads to a delay in administration of appropriate treatment, thus increasing the risk of death. The use of validated clinical criteria can facilitate the diagnosis of anaphylaxis. Intramusc...
Source: Clinical and Translational Allergy - December 11, 2017 Category: Allergy & Immunology Source Type: research
Lung function in severe pediatric asthma: a longitudinal study in children and adolescents in Brazil
ConclusionsThe fact that the spirometric parameters (as percentages of the predicted values) remained constant in the> 800 µg/day group, whereas there was a gain in lung function in the sample as a whole, suggests an early plateau phase in the> 800 µg/day group. However, there was some loss of lung function in the> 800 µg/day group, as evidenced by a decrease in the z-score for FEF25 –75%, suggesting irreversible small airway impairment, and by a reduction in the post-bronchodilator FEV1%, suggesting reduced reversibility of airway obstruction. Among children and adolescents with severe asthma, the u...
Source: Clinical and Translational Allergy - December 15, 2017 Category: Allergy & Immunology Source Type: research
MI (2-methyl-4-isothiazolin-3-one) contained in detergents is not detectable in machine washed textiles
ConclusionIt is important to discuss the difference of risk and hazard. While MI clearly is a high hazard as a strong contact allergen, the risk depends on exposure. Regarding the risk of exposure levels for the consumer to MI in clothes it can be stated that the use of MI in laundry detergents is safe for the consumer if these products are used according to the instructions in the normal household setting machine wash.
Source: Clinical and Translational Allergy - January 5, 2018 Category: Allergy & Immunology Source Type: research
Stevens –Johnson syndrome/toxic epidermal necrolysis and erythema multiforme drug-related hospitalisations in a national administrative database
ConclusionsSJS/TEN in-hospital mortality is high, and its risk factors include advanced age, liver disease, and TEN diagnosis. The drug classes most frequently associated with these conditions include antivirals, hypouricaemic drugs and antineoplastic/immunosuppressive drugs. Administrative databases seem useful in the study of SJS/TEN drug-related hospitalisations, yielding results consistent with previous studies and on a nationwide basis.
Source: Clinical and Translational Allergy - January 22, 2018 Category: Allergy & Immunology Source Type: research
Interleukin-25 and eosinophils progenitor cell mobilization in allergic asthma
ConclusionsThe findings of this study indicate a potential role for IL-25 in allergen-induced trafficking of EoP to the airways and local differentiation promoting tissue eosiniophilia in asthmatic responses.
Source: Clinical and Translational Allergy - February 13, 2018 Category: Allergy & Immunology Source Type: research
On-demand intermittent beclomethasone is effective for mild asthma in Brazil
ConclusionClinicians might consider intermittent inhaled steroid therapy as a therapeutic regimen for mild persistent asthma.Trial registration The Portuguese and English versions of the study protocol were submitted, approved, and registered in the Brazilian Network Platform for Clinical Trials (http://www.ensaiosclinicos.gov.br) under the primary identifier number “RBR-3gbyhk”. This platform is part of the Primary Registries in the World Health Organization Registry Network, where the trial is registered under the following Universal Trial Number: 1111-1149-4774
Source: Clinical and Translational Allergy - March 5, 2018 Category: Allergy & Immunology Source Type: research
The kinase LRRK2 is differently expressed in chronic rhinosinusitis with and without nasal polyps
ConclusionLRRK2 and NRON may play different role in CRSsNP and CRSwNP. The molecular mechanisms identified here may aid in the design of novel therapeutic strategies to improve clinical outcomes.
Source: Clinical and Translational Allergy - March 12, 2018 Category: Allergy & Immunology Source Type: research
Effectiveness of icatibant for treatment of hereditary angioedema attacks is not affected by body weight: findings from the Icatibant Outcome Survey, a cohort observational study
ConclusionOverall, icatibant was comparatively effective in treating attacks in patients across all BMI groups.Trial registration NCT01034969.
Source: Clinical and Translational Allergy - March 23, 2018 Category: Allergy & Immunology Source Type: research
Pollen and spore monitoring in the world
ConclusionsThe map shows the current situation of pollen and spore monitoring and facilitates collaboration among those individuals who are interested in pollen and spore counts. It might also help to improve the monitoring of biological particles up to the current level employed for non-biological components.
Source: Clinical and Translational Allergy - April 4, 2018 Category: Allergy & Immunology Source Type: research
Diverse expression of TNF- α and CCL27 in serum and blister of Stevens–Johnson syndrome/toxic epidermal necrolysis
ConclusionsOur study demonstrated roles of CCL27 and TNF- α in promoting the course of SJS/TEN. CCL27 may act early in the course of disease, via the circulation, whereas TNF-α acts throughout the course of disease, in skin lesions.
Source: Clinical and Translational Allergy - April 20, 2018 Category: Allergy & Immunology Source Type: research
Consideration of methods for identifying mite allergens
AbstractHouse dust mites are small arthropods that produce proteins —found in their feces, body parts, and eggs—that are major triggers of human allergies worldwide. The goal of this review is to describe the current methods used to identify these allergens. A literature search for allergen identification methods employed between 1995 and 2016 revealed multiple techniques that can be broadly grouped into discovery and confirmation phases. The discovery phase employs screening for mite proteins that can bind IgEs in sera from animals or patients allergic to dust mites. The confirmation phase employs biochemical methods ...
Source: Clinical and Translational Allergy - April 27, 2018 Category: Allergy & Immunology Source Type: research
7th International Symposium on Molecular Allergology (ISMA 2017)
Source: Clinical and Translational Allergy - May 3, 2018 Category: Allergy & Immunology Source Type: research
