Lung function in severe pediatric asthma: a longitudinal study in children and adolescents in Brazil

ConclusionsThe fact that the spirometric parameters (as percentages of the predicted values) remained constant in the>  800 µg/day group, whereas there was a gain in lung function in the sample as a whole, suggests an early plateau phase in the>  800 µg/day group. However, there was some loss of lung function in the>  800 µg/day group, as evidenced by a decrease in the z-score for FEF25 –75%, suggesting irreversible small airway impairment, and by a reduction in the post-bronchodilator FEV1%, suggesting reduced reversibility of airway obstruction. Among children and adolescents with severe asthma, the use of ICS doses higher than those recommended for age does not appear to improve lung function.
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research