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Source: Current Treatment Options in Allergy

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Total 345 results found since Jan 2013.

p-Phenylenediamine and Risk of Sensitization in Children
Opinion statement Contact allergy to p-phenylenediamine (PPD) in children has been described over almost 2 decades, indicating a major problem. PPD can be found in permanent hair dyes and temporary henna tattoos. Children often get sensitized to PPD at a relatively young age when getting a temporary henna tattoo while away on holiday in exotic surroundings. This results in a localized acute allergic reaction at the site of the tattoo within 1–2 weeks after the tattoo has been drawn. The symptoms will clear over weeks on treatment with topical corticosteroids. However, sensitization to PPD will be life-long and...
Source: Current Treatment Options in Allergy - September 1, 2014 Category: Allergy & Immunology Source Type: research

Occupational Allergic Rhinitis: What Do We Know?
Opinion statement • The main objectives of the management of occupational rhinitis are, elimination of symptoms and prevention of development of asthma. • Management strategies include, environmental interventions (cessation or reducing the exposure to the causal agent) and appropriate pharmacologic treatment. • Drug therapy does not differ from non-occupational rhinitis. • Given the increased risk for occupational asthma in patients with occupational rhinitis, the most effective approach is complete avoidance of exposure to the offending agent. However, if complete cessation of ...
Source: Current Treatment Options in Allergy - December 16, 2014 Category: Allergy & Immunology Source Type: research

Using Component-Resolved Diagnostics in the Management of Peanut-Allergic Patients
Opinion statement Instead of relying on crude peanut extract, component-resolved diagnostics (CRD) uses sensitization to allergenic proteins within peanut. In this review, we describe the recent advances and future perspectives of the use of CRD in the management of peanut-allergic patients. There is strong evidence that sensitization to Ara h 2 is the best predictor for clinically relevant peanut allergy in children and adults. Isolated sensitization to other peanut components is only rarely present in patients with systemic reactions to peanut. It is, however, important to remark that cut-off points of sIgE to A...
Source: Current Treatment Options in Allergy - April 6, 2016 Category: Allergy & Immunology Source Type: research

Prevention of Anaphylaxis Based on Risk Factors and Cofactors
Opinion statement Anaphylaxis is most commonly caused by drugs, food, and hymenoptera stings, or in certain instances may be idiopathic. A variety of risk factors, cofactors, and augmenting factors may act together to trigger anaphylaxis. Patients with certain underlying medical conditions may be at increased risk of anaphylaxis of certain etiologies, e.g., monoclonal mast cell activation syndromes and insect venom anaphylaxis, asthma, and fatal food-induced anaphylaxis especially in adolescents. Identification of risk factors, cofactors, and augmenting factors during clinical assessment is key to determining the ...
Source: Current Treatment Options in Allergy - July 12, 2016 Category: Allergy & Immunology Source Type: research

Desensitization for Peanut Allergies in Children
This article will describe the immunotherapy approaches that are being investigated to induce peanut desensitization, and highlight the benefits and risks of these therapies that need to be considered before they are ready for routine clinical practice.
Source: Current Treatment Options in Allergy - July 20, 2016 Category: Allergy & Immunology Source Type: research

Wheat-Dependent Exercise-Induced Anaphylaxis
Opinion statementWheat-dependent exercise-induced anaphylaxis (WDEIA) is presently gaining attention. Patients with WDEIA experience allergic symptoms when they exercise following wheat consumption. Some patients may be advised to restrict wheat consumption or exercise because of repeated allergic symptoms without adequate diagnosis or examination. Japanese guidelines recommend that WDEIA should be diagnosed using provocation tests with wheat and exercise. After wheat consumption, patients exercise using a treadmill or an ergometer during provocation tests. Once WDEIA is diagnosed, patients should not consume wheat before ...
Source: Current Treatment Options in Allergy - June 1, 2017 Category: Allergy & Immunology Source Type: research

Alpha-Gal Syndrome: Clinical Presentation, New Concepts, and Unmet Needs
Opinion statementFor decades, carbohydrate determinants were seen as cross-reactive structures without clinical impact. The discovery of specific IgE to the carbohydrate galactose- α-1,3-galactose, called α-gal, changed our perspective on the allergenic potential of carbohydrate determinants. α-Gal is present in tissues of non-primate mammals and, upon ingestion, can provoke a delayed form of allergic reaction in sensitized patients. We are faced with a new and unique entit y of allergy with high clinical relevance in food allergy and anaphylaxis to drugs derived from mammalian products. Tick bites are assumed to consti...
Source: Current Treatment Options in Allergy - June 2, 2017 Category: Allergy & Immunology Source Type: research

How Can We Influence the Performance of Drug Challenge in Future Treatment
AbstractDrug provocation tests are assumed to be the gold standard of drug allergy workup by ensuring the most objective results in clinical observation irrespective of the underlying mechanism of the reaction. Despite its some disadvantages, it is still one of the cornerstones of the drug allergy diagnosis. In this review, new methods for improving diagnostic accuracy of drug provocation tests will be discussed. In this sense, extended challenges are recently shown to have better outcome especially in diagnosing non-immediate reactions due to antibiotics. In children with non-immediate mild cutaneous reactions, provocatio...
Source: Current Treatment Options in Allergy - January 25, 2018 Category: Allergy & Immunology Source Type: research

Risk Factors for Adverse Reactions During OIT
AbstractPurpose of reviewOral immunotherapy (OIT) can have a major positive impact on patients with IgE-mediated food allergies, increasing reaction thresholds and reducing the need for dietary and lifestyle limitations. However, patients experience more frequent allergic reactions during OIT than when following dietary avoidance, and 10 –75% of patients on OIT may experience anaphylaxis to treatment doses. Our ability to identify patients at higher risk of more severe or frequent reactions during OIT is limited. We review the current data available and highlight the gaps in knowledge which impede our ability to predict ...
Source: Current Treatment Options in Allergy - April 30, 2019 Category: Allergy & Immunology Source Type: research

Importance of Diagnostics Prior to Desensitization in New Drug Hypersensitivity: Chemotherapeutics and Biologicals
AbstractPurpose of reviewIn this review article, we intend to summarize the diagnostic tools available for the study of drug hypersensitivity reactions to chemotherapy and biologicals, based on the experience and controversies of the main research groups leading the topic.Recent findingsRecent publications with large cohorts of patients reacting to these drugs are allowing for a better understanding of phenotyping, endotyping, and optimally managing these patients.SummaryThere is a remarkable heterogeneity on the diagnostic and therapeutic approach among the different groups, and yet this has allowed for very interesting d...
Source: Current Treatment Options in Allergy - January 9, 2020 Category: Allergy & Immunology Source Type: research

Anaphylaxis Induced by Magnetic Resonance Imaging (MRI) Contrast Media
Opinion statementPurpose of reviewThe aim of this document is to review the epidemiology, diagnosis, and treatment of immediate and anaphylactic reactions to gadolinium-based contrast agents (GBCA) most commonly used in magnetic resonance imaging (MRI).Recent findingsThe frequency of adverse reactions to GBCA ranges from 0.04 to 2.2%. Most reactions are mild (47% –95%) and the frequency of anaphylactic shock is 0.004%–0.01%. Mortality due to anaphylaxis induced by GBCAs has been 0.0019%.Allergic reactions are more frequent in patients with a previous reaction, in females, using macrocycle estructure GBCA and with hepat...
Source: Current Treatment Options in Allergy - January 29, 2020 Category: Allergy & Immunology Source Type: research

Quinolone-Induced Anaphylaxis
AbstractPurpose of reviewQuinolones are the second most common antibiotic class that may induce IgE and non-IgE-mediated immediate hypersensitivity reactions. The prevalence of true quinolone allergy still remains unknown, but its incidence has increased in recent years, probably due to the extensive utilization of this antibiotic class and the introduction of moxifloxacin.Recent findingsQuinolones may also induce nonallergic reactions through the MRGPRX2 receptor. The diagnosis of hypersensitivity reactions to quinolones is complex, since clinical history is often doubtful, skin tests can induce false-positive results, an...
Source: Current Treatment Options in Allergy - June 1, 2020 Category: Allergy & Immunology Source Type: research

Shrimp-Induced Anaphylaxis
AbstractPurpose of ReviewShrimp and other crustaceans and molluscs are one of the most frequent causes of food allergy and anaphylaxis at all ages. Molecular biology has paved the way to a better understanding of the allergen profile of invertebrates that is much more complex than thought only one decade ago.Recent FindingsWhile tropomyosin has been traditionally considered as the dominating major allergen in crustaceans and other invertebrates, recent research demonstrated that IgE to this allergen can be detected in about 50% of shrimp-allergic patients only. Many of these allergens are conserved ones and, hence, potenti...
Source: Current Treatment Options in Allergy - June 28, 2020 Category: Allergy & Immunology Source Type: research

Allergen Preparation in AIT, Now and in the Future
Opinion StatementPurpose of ReviewAt present,in vivo allergy diagnosis and allergen-specific immunotherapy (AIT) are still based on allergens extracted from natural material. The inherent content and activity change of allergen source cannot be resolved, which impedes the standardization of AIT and limits doctors ’ desire to recommend it.Recent FindingsWith the increasing use of allergen molecules in allergy diagnosis, the molecular allergens in AIT are believed to be the future trend. However, the current clinical phase III trials are not satisfying. Improvements have been made in the field of allergen extracts or molec...
Source: Current Treatment Options in Allergy - March 5, 2021 Category: Allergy & Immunology Source Type: research

Updated Criteria to Include Contact Allergens in the European Baseline Series With Suggested Additions
This article discusses these shifts in exposure and hence potential additions and deletions from the EBS.Recent findingsThe formaldehyde-releasing preservatives imidazolidinyl urea 2% pet., diazolidinyl urea 2% pet. and 2-bromo-2-nitropropane-1,3-diol 0.5% pet. should be considered for inclusion in the EBS as published data has shown formaldehyde 2% aq. is an inadequate screen for contact allergy to the formaldehyde releasers. Other potential additions include isothiazolinones preservatives, sodium metabiosulphite, linalool hydroperoxide and limonene hydroperoxide, Compositae mix II, sorbitan monooleate and sorbitan sesqui...
Source: Current Treatment Options in Allergy - April 1, 2022 Category: Allergy & Immunology Source Type: research