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Source: Journal of Experimental and Clinical Cancer Research

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Total 25 results found since Jan 2013.

Sustained delivery of siRNA/PEI complex from in situ forming hydrogels potently inhibits the proliferation of gastric cancer
Gastric cancer remains a major cause of mortality and morbidity worldwide. In recent years, gene-based therapeutic strategies were confirmed promising in cancer inhibition and attracted great attention. RNA in...
Source: Journal of Experimental and Clinical Cancer Research - March 31, 2016 Category: Cancer & Oncology Authors: Hao Peng, Huawei Yang, Liwei Song, Zheng Zhou, Jinwen Sun, Yunfeng Du, Keyu Lu, Tao Li, Aiguo Yin, Jianhua Xu and Shidong Wei Source Type: research

Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition
Conclusions: These results provide a further insight into the molecular mechanisms affected by crizotinib in ARMS cells inferring that it could be a useful therapeutic tool in ARMS cancer treatment.
Source: Journal of Experimental and Clinical Cancer Research - October 6, 2015 Category: Cancer & Oncology Authors: Francesca MegiorniHeather McDowellSimona CameroOlga MannarinoSimona CeccarelliMilena PaianoPaul LostyBarry PizerRajeev ShuklaAntonio PizzutiAnna ClericoCarlo Dominici Source Type: research

Overexpression of P21-activated kinase 4 is associated with poor prognosis in non-small cell lung cancer and promotes migration and invasion
Conclusions: These data demonstrate that PAK4 mediated LIMK1 phosphorylation regulates the migration and invasion in NSCLC. Therefore, PAK4 might be a significant prognostic marker and potential therapeutic molecular target in NSCLC.
Source: Journal of Experimental and Clinical Cancer Research - May 15, 2015 Category: Cancer & Oncology Authors: Songwang CaiZhiqiang YeXiaohong WangYuhang PanYimin WengSen LaoHongbo WeiLian Li Source Type: research

MicroRNA-144 inhibits the metastasis of gastric cancer by targeting MET expression
Gastric cancer (GC) remains one of the most common types of malignant cancer, and the molecular mechanism underlying its metastasis is still largely unclear. MicroRNAs have emerged as important regulators of metastasis because of their ability to act on multiple signaling pathways. In our study, we found that miR-144 is significantly downregulated in both highly metastatic GC cell lines and tissues. Results from both gain-of-function and loss-of-function experiments demonstrate that increased miR-144 expression significantly reduced GC cell migration, whereas decreased miR-144 expression dramatically enhanced GC cell migra...
Source: Journal of Experimental and Clinical Cancer Research - April 17, 2015 Category: Cancer & Oncology Authors: Jun LiuHui XueJianjun ZhangTao SuoYijin XiangWen ZhangJun MaDingfang CaiXixi Gu Source Type: research

DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas
Conclusion: Taken together, whereas DEC2 was found to promote HIF-1α degradation in other types of tumors, our data indicate that DEC2 facilitates HIF-1α stabilization and promotes HIF-1 activation in osteosarcoma. This implies that DEC2 may contribute to the progression and metastasis of human osteosarcoma by sensitizing tumor cells to hypoxia. On the other hand, HIF-1 activation may contribute to the expression of DEC2 in osteosarcoma. This is the first demonstration of a novel DEC2-HIF-1 vicious cycle in osteosarcoma and a tumor-type specific role for DEC2.
Source: Journal of Experimental and Clinical Cancer Research - February 28, 2015 Category: Cancer & Oncology Authors: Tu HuNengbin HeYunsong YangChengqian YinNianli SangQingcheng Yang Source Type: research

Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinoma
Conclusions: This study demonstrates the oncogenic role of Pim-1 in ACC. The findings also suggest that Pim-1 may serve as a neoteric therapeutic target and potential prognostic marker for ACC cancer.
Source: Journal of Experimental and Clinical Cancer Research - December 31, 2014 Category: Cancer & Oncology Authors: Xin ZhuJia-jie XuSi-si HuJian-guo FengLie-hao JiangXiu-xiu HouJun CaoJing HanZhi-qiang LingMing-hua Ge Source Type: research

MicroRNA-34a functions as an anti-metastatic microRNA and suppresses angiogenesis in bladder cancer by directly targeting CD44
Conclusion: Our study defines a major metastasis and angiogenesis suppressive role for mir-34a, a microRNA functions as a tumor suppressor in bladder cancer by directly targeting CD44, which would be helpful as a therapeutic approach to block bladder cancer metastasis.
Source: Journal of Experimental and Clinical Cancer Research - December 31, 2014 Category: Cancer & Oncology Authors: Gan YuWeimin YaoWei XiaoHeng LiHua XuBin Lang Source Type: research

Parathyroid hormone-related protein serves as a prognostic indicator in oral squamous cell carcinoma
This study showed that the mRNA and protein levels of PTHLH in 9 OSCC cell lines were much higher than that in normal epithelial cells (P
Source: Journal of Experimental and Clinical Cancer Research - December 18, 2014 Category: Cancer & Oncology Authors: Zhongjing LvXiangbing WuWei CaoZongZe ShenLizhen WangFuRong XieJianJun ZhangTong JiMing YanWanTao Chen Source Type: research

The role of microRNA-133b and its target gene FSCN1 in gastric cancer
Conclusion: Our findings demonstrated that miR-133b was significantly down-regulated in GC tissues and exerted its tumor suppressor role in GC cells. The investigation of the detailed mechanism showed that miR-133b directly targeted FSCN1 which functioned as an oncogenic gene in GC cells. These results suggested that miR-133b can be developed as a new diagnostic marker or therapeutic target for GC.
Source: Journal of Experimental and Clinical Cancer Research - November 30, 2014 Category: Cancer & Oncology Authors: Lihua GuoHua BaiDongling ZouTao HongJie LiuJiaqiang HuangPengfei HeQi ZhouJinsheng He Source Type: research

Reciprocal regulation of PCGEM1 and miR-145 promote proliferation of LNCaP prostate cancer cells
Prostate cancer gene expression marker 1 (PCGEM1) is a long non-coding RNA (lncRNA) overexpressed in prostate cancer (PCa) cells that promotes PCa initiation and progression, and protects against chemotherapy-induced apoptosis. The microRNA miR-145 functions as a tumor suppressor in PCa. We speculate that reciprocal regulation of PCGEM1 and miR-145 promote proliferation of LNCaP prostate cancer cells. To test this hypothesis, the interaction between PCGEM1 and miR-145 was examined using a luciferase reporter assay. Expression levels were selectively altered in LNCaP cells and noncancerous RWPE-1 prostate cells by transfect...
Source: Journal of Experimental and Clinical Cancer Research - September 10, 2014 Category: Cancer & Oncology Authors: Jin-Hua HeJing-zhi ZhangZe-Ping HanLi WangYu LvYu-Guang Li Source Type: research

Histone deacetylase 8 is deregulated in urothelial cancer but not a target for efficient treatment
Conclusions: Deregulation of HDAC8 is frequent in urothelial cancer, but neither specific pharmacological inhibition nor siRNA-mediated knockdown of HDAC8 impaired viability of urothelial cancer cell lines in a therapeutic useful manner. Accordingly, HDAC8 on its own is not a promising drug target in bladder cancer.
Source: Journal of Experimental and Clinical Cancer Research - July 10, 2014 Category: Cancer & Oncology Authors: Maria LehmannMichèle HoffmannAnnemarie KochScott UlrichWolfgang SchulzGünter Niegisch Source Type: research

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