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Source: Nanomedicine : Nanotechnology, Biology, and Medicine

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Total 55 results found since Jan 2013.

Intranasal Brain Delivery of Cationic Nanoemulsion-Encapsulated TNFα siRNA in Prevention of Experimental Neuroinflammation
Neuroinflammation is a hallmark of acute and chronic neurodegenerative disorders. Activated microglia and secreted factors such as tumor necrosis factor-alpha (TNFα) are key mediators of neuroinflammation and may contribute to neuronal dysfunction. The main aim of this study was to evaluate the therapeutic efficacy of intranasal cationic nanoemulsions encapsulating an anti-TNFα siRNA, for potential anti-inflammatory therapy, tested in an LPS induced model of neuroinflammation. The strategy of developing a cationic nanoemulsion system for silencing the TNFα gene was to efficiently provide neuroprotection against inflammation.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - January 5, 2016 Category: Nanotechnology Authors: Sunita Yadav, Srujan K. Gandham, Riccardo Panicucci, Mansoor M. Amiji Source Type: research

Folate-targeted Amphiphilic Cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo
In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-formulating CD.siRNA complexes with DSPE-PEG5000-folate to target the prostate specific membrane antigen (PSMA). Targeted formulations showed increased uptake, relative to untargeted controls, in two prostate cancer cell lines expressing PSMA (VCaP and LNCaP). Competitive uptake studies, using excess folate, significantly reduced uptake of targeted nanoparticles in PSMA positive cell lines (p
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - July 3, 2016 Category: Nanotechnology Authors: James C. Evans, Meenakshi Malhotra, Jianfeng Guo, Joseph P. O'Shea, Karen Hanrahan, Amanda O'Neill, William Landry, Brendan T. Griffin, Raphael Darcy, R. William Watson, Caitriona M. O'Driscoll Source Type: research

Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo
In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-formulating CD.siRNA complexes with DSPE-PEG5000-folate to target the prostate specific membrane antigen (PSMA). Targeted formulations showed increased uptake, relative to untargeted controls, in two prostate cancer cell lines expressing PSMA (VCaP and LNCaP). Competitive uptake studies, using excess folate, significantly reduced uptake of targeted nanoparticles in PSMA positive cell lines (P
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - July 3, 2016 Category: Nanotechnology Authors: James C. Evans, Meenakshi Malhotra, Jianfeng Guo, Joseph P. O'Shea, Karen Hanrahan, Amanda O'Neill, William Landry, Brendan T. Griffin, Raphael Darcy, R. William Watson, Caitriona M. O'Driscoll Source Type: research

Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models
Epithelial ovarian cancer (EOC) is the most deadly gynecologic malignancy on account of its late stage at diagnosis and frequency of drug resistant recurrences. Novel therapies to overcome these barriers are urgently needed. TWIST is a developmental transcription factor reactivated in cancers and linked to angiogenesis, metastasis, cancer stem cell phenotype, and drug resistance, making it a promising therapeutic target. In this work, we demonstrate the efficacy of TWIST siRNA (siTWIST) and two nanoparticle delivery platforms to reverse chemoresistance in EOC models.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - November 23, 2016 Category: Nanotechnology Authors: Cai M. Roberts, Sophia Allaf Shahin, Wei Wen, James B. Finlay, Juyao Dong, Ruining Wang, Thanh H. Dellinger, Jeffrey I. Zink, Fuyuhiko Tamanoi, Carlotta A. Glackin Tags: Original Article Source Type: research

Combinatorial treatment of idiopathic pulmonary fibrosis using nanoparticles with prostaglandin E and siRNA(s)
Inhalation delivery of prostaglandin E (PGE2) in combination with selected siRNA(s) was proposed for the efficient treatment of idiopathic pulmonary fibrosis (IPF). Nanostructured lipid carriers (NLC) were used as a delivery system for PGE2 with and without siRNAs targeted to MMP3, CCL12, and HIF1Alpha mRNAs. The model of IPF was developed in SKH1 mice by intratracheal administration of bleomycin at a dose of 1.5U/kg. Results showed that NLC-PGE2 in combination with three siRNAs delivered locally to the lungs by inhalation markedly reduced mouse body mass, substantially limited hydroxyproline content in the lungs and distu...
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - April 18, 2017 Category: Nanotechnology Authors: O.B. Garbuzenko, V. Ivanova, V. Kholodovych, D.C. Reimer, K.R. Reuhl, E. Yurkow, D. Adler, T. Minko Source Type: research

Mannose-conjugated layered double hydroxide nanocomposite for targeted siRNA delivery to enhanced cancer therapy
Sheet-like layered double hydroxide nanoparticles (LDH NPs) have showed great potentials in biomedical applications such as nanocarriers for drug and gene delivery, biosensors and imaging agents. However, target delivery of drugs and genes using LDH NPs to the desired tumor sites is a major challenge in cancer therapy. The aim of this study is to develop a functional LDH-based nanocomposite for target delivery of siRNA to cancer cells. Mannose as a targeting moiety was firstly conjugated onto SiO2-coated LDH nanocomposite.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - June 22, 2017 Category: Nanotechnology Authors: Li Li, Run Zhang, Wenyi Gu, Zhi Ping Xu Source Type: research

Mannose-conjugated layered double hydroxide nanocomposite for targeted siRNA delivery to enhance cancer therapy
Sheet-like layered double hydroxide nanoparticles (LDH NPs) have showed great potentials in biomedical applications such as nanocarriers for drug and gene delivery, biosensors and imaging agents. However, target delivery of drugs and genes using LDH NPs to the desired tumor sites is a major challenge in cancer therapy. The aim of this study is to develop a functional LDH-based nanocomposite for target delivery of siRNA to cancer cells. Mannose as a targeting moiety was firstly conjugated onto SiO2-coated LDH nanocomposite.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - June 22, 2017 Category: Nanotechnology Authors: Li Li, Run Zhang, Wenyi Gu, Zhi Ping Xu Tags: Special Topic: Two-Dimensional Biomaterials in Regenerative Medicine Source Type: research

Amelioration of cirrhotic portal hypertension by targeted cyclooxygenase-1 siRNA delivery to liver sinusoidal endothelium with polyethylenimine grafted hyaluronic acid
In this study, hyaluronate-graft-polyethylenimine (HA-PEI) was synthesized for the targeted delivery of COX-1 siRNA to LSECs.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - July 13, 2017 Category: Nanotechnology Authors: Liteng Lin, Mingyue Cai, Shaohui Deng, Wensou Huang, Jingjun Huang, Xinghua Huang, Mingsheng Huang, Yong Wang, Xintao Shuai, Kangshun Zhu Source Type: research

Amphiphilic poly( α)glutamate polymeric micelles for systemic administration of siRNA to tumors
RNAi therapeutics carried a great promise to the area of personalized medicine: the ability to target “undruggable” oncogenic pathways. Nevertheless, their efficient tumor targeting via systemic administration had not been resolved yet. Amphiphilic alkylated poly(α)glutamate amine (APA) can serve as a cationic carrier to the negatively-charged oligonucleotides. APA polymers complexed with siRNA to form round-shaped, homogenous and reproducible nano-sized polyplexes bearing ~50nm size and slightly negative charge.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - November 7, 2017 Category: Nanotechnology Authors: Adva Krivitsky, Dina Polyak, Anna Scomparin, Shay Eliyahu, Paula Ofek, Galia Tiram, Hagar Kalinski, Sharon Avkin-Nachum, Nat àlia Feiner Gracia, Lorenzo Albertazzi, Ronit Satchi-Fainaro Source Type: research

Mannose-conjugated layered double hydroxide nanocomposite for targeted siRNA delivery to enhance cancer therapy
Sheet-like layered double hydroxide nanoparticles (LDH NPs) have showed great potentials in biomedical applications such as nanocarriers for drug and gene delivery, biosensors and imaging agents. However, target delivery of drugs and genes using LDH NPs to the desired tumor sites is a major challenge in cancer therapy. The aim of this study is to develop a functional LDH-based nanocomposite for target delivery of siRNA to cancer cells. Mannose as a targeting moiety was firstly conjugated onto SiO2-coated LDH nanocomposite.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - June 22, 2017 Category: Nanotechnology Authors: Li Li, Run Zhang, Wenyi Gu, Zhi Ping Xu Tags: Special Topic: Two-Dimensional Biomaterials in Regenerative Medicine Source Type: research

Targeted delivery of Dicer-substrate siRNAs using a dual targeting peptide decorated dendrimer delivery system
Small interfering RNAs (siRNA) are emerging as novel therapeutic agents, providing competent delivery systems that are available. Dendrimers, a special family of synthetic macromolecules, represent an exciting delivery platform by virtue of their well-defined dendritic structure and unique multivalency and cooperativity confined within a nanoscale volume. Here, we report a Dicer-substrate siRNA (dsiRNA) which, when delivered using a structurally flexible triethanolamine-core poly(amidoamine) dendrimer of generation 5 as the nanocarrier, gives rise to a much greater RNAi response than that produced with conventional siRNA.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - June 2, 2014 Category: Nanotechnology Authors: Xiaoxuan Liu, Cheng Liu, Chao Chen, Mélanie Bentobji, Francine Azario Cheillan, Jeanne Thomassin Piana, Fanqi Qu, Palma Rocchi, Ling Peng Source Type: research

Chemo-biologic combinatorial drug delivery using folate receptor-targeted dendrimer nanoparticles for lung cancer treatment
Co-administration of functionally distinct anti-cancer agents has emerged as an efficient strategy in lung cancer treatment. However, a specially designed drug delivery system is required to co-encapsulate functionally different agents, such as a combination of siRNA and chemotherapy, for targeted delivery. We developed a folic acid (FA) -conjugated polyamidoamine dendrimer (Den) -based nanoparticle (NP) system for co-delivery of siRNA against HuR mRNA (HuR siRNA) and cis-diamine platinum (CDDP) to folate receptor- α (FRA) -overexpressing H1299 lung cancer cells.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - November 16, 2017 Category: Nanotechnology Authors: Narsireddy Amreddy, Anish Babu, Janani Panneerselvam, Akhil Srivastava, Ranganayaki Muralidharan, Allshine Chen, Yan D. Zhao, Anupama Munshi, Rajagopal Ramesh Source Type: research

Recent development of silica nanoparticles as delivery vectors for cancer imaging and therapy
Abstract: In spite of significant advances in early detection and combined treatments, a number of cancers are often diagnosed at advanced stages and thereby carry a poor prognosis. Developing novel prognostic biomarkers and targeted therapies may offer alternatives for cancer diagnosis and treatment. Recent rapid development of nanomaterials, such as silica based nanoparticles (SiNPs), can just render such a promise. In this article, we attempt to summarize the recent progress of SiNPs in tumor research as a novel delivery vector. SiNP-assisted imaging techniques are used in cancer diagnosis both in vitro and in vivo. Mea...
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - September 11, 2013 Category: Nanotechnology Authors: Xu Wu, Min Wu, Julia Xiaojun Zhao Tags: Pathology, Neoplasms, Drug Delivery, Imaging, Therapy, Silica NPs Source Type: research

Targeted-gene silencing of BRAF to interrupt BRAF/MEK/ERK pathway synergized photothermal therapeutics for melanoma using a novel FA-GNR-siBRAF nanosystem
Melanoma is significantly associated with mutant BRAF gene, a suitable target for siRNA-based anti-melanoma therapy. However, a tumor-specific delivery system is a major hurdle for clinical applications. Here, we developed a novel nano-carrier, FA-GNR-siBRAF for safe topical application, which consists of folic acid (FA) as the tumor-targeting moiety, golden nanorods (GNR) providing photothermal capability to kill tumor cells under laser irradiation, and siRNA specifically silencing BRAF (siBRAF).
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - April 20, 2018 Category: Nanotechnology Authors: Yujuan Zhang, Xuelin Zhan, Shanshan Peng, Ying Cai, Yu Shrike Zhang, Yanling Liu, Zhigang Wang, Yanrong Yu, Yifan Wang, Qiaofa Shi, Xiaoping Zeng, Keng Yuan, Nanjin Zhou, Rakesh Joshi, Meng Zhang, Zhuxu Zhang, Weiping Min Source Type: research