• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Long Non-coding RNA CRNDE Promotes Multiple Myeloma Cell Growth By Suppressing MiR-451.
In this study, we found that the CRNDE expression level, in MM sample and cell lines, is higher than control detected by real-time qPCR, which is also closely related to tumor progression and poor survival in MM patients. Afterwards, knockdown of CRNDE significantly inhibits the proliferative vitality of MM cells (U266 and RPMI8226), meanwhile, induces cell cycle arrest in G0/G1 phase and apoptosis-promoting. After being transfected with siRNA, miR-451 expression observably increases. Bioinformatics analysis and luciferase assay reveal the interaction complementary bonding between CRNDE and miR-451. Pearson's correlation s...
Source: Oncology Research - March 10, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Long Non-Coding RNA PVT1 Facilitates Cervical Cancer Progression Via Negative Regulating of miR-424.
Authors: Gao YL, Zhao ZS, Zhang MY, Han LJ, Dong YJ, Xu B Abstract Emerging evidence suggests that the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 gene (PVT1) is involved in pathogenesis of cervical cancer. However, the potential mechanism is rarely reported. Our study found that PVT1 was up-regulated in cervical cancer tissue and cell lines. After transfecting PVT1 siRNA, the proliferation, migration and invasion of cervical cancer cells were markedly decreased. MiRNA expression profiles demonstrate that miR-424 was markedly down-regulated in cervical cancer tissue. Bioinformatics analysis re...
Source: Oncology Research - March 10, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

CSTB Downregulation Promotes Cell Proliferation and Migration and Suppresses Apoptosis in Gastric Cancer SGC-7901 Cell Line.
This study aimed to investigate the pivotal role of cystatin B (CSTB) in the development of gastric cancer and to explore its possible regulatory mechanism. Human gastric cancer SGC-7901 cells as a model in vitro were transfected with plasmid PCDNA3.1-CSTB and siRNA-CSTB using Lipofectamine 2000. Quantitative real-time PCR (qRT-PCR) and Western blotting were performed to determine the relative expression of CSTB and PI3K/Akt/mTOR pathway-related protein. Moreover, MTT assay, Transwell assay, and flow cytometry were used to assess cell proliferation, migration, and apoptosis, respectively. The results showed that CSTB was s...
Source: Oncology Research - March 12, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

miR-183 Modulates Cell Apoptosis and Proliferation in Tongue Squamous Cell Carcinoma SCC25 Cell Line.
In conclusion, miR-183 contributed to cell growth and proliferation, and suppressed cell apoptosis in SCC25 cells. Therefore, miR-183 might serve as a therapeutic target in tongue squamous cell carcinoma (TSCC). PMID: 28281960 [PubMed - in process]
Source: Oncology Research - March 12, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

G-Protein Signaling Protein-17 (RGS17) is Upregulated and Promotes Tumor Growth and Migration in Human Colorectal Carcinoma.
Authors: Li L, Luo HS Abstract Colorectal carcinoma is one of the leading causes of cancer-related deaths and has a high tendency for metastasis, which makes it a priority to find novel methods to diagnose and treat colorectal carcinoma in the very early stage. Herein, we studied the role of regulators of G-protein signaling (RGS) family protein RGS17 in colorectal carcinoma growth and metastasis. We found that RGS17 was upregulated in both clinical colorectal carcinoma tissues and cultured colorectal carcinoma cells. Knockdown of RGS17 by specific siRNA decreased, whereas overexpression of RGS17 with expression pl...
Source: Oncology Research - March 27, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Regulation of Acetate Utilization By Monocarboxylate Transporter 1 (MCT1) in Hepatocellular Carcinoma (HCC).
Authors: Jeon J, Lee M, Whang S, Kim JW, Cho A, Yun M Abstract Altered energy metabolism is a biochemical fingerprint of cancer cells. Hepatocellular carcinoma (HCC) shows reciprocal18F-Fluorodeoxyglucose (FDG) and 11C-acetate uptake, as revealed by positron emission tomography/computed tomography (PET/CT). Previous studies have focused on the role of FDG uptake in cancer cells; in this study, we evaluated the mechanism and roles of 11C-acetate uptake in human HCCs and cell lines. The expression of monocarboxylate transporters (MCTs) was assessed to determine the transporters of 11C-acetate uptake in HCC cell lines...
Source: Oncology Research - April 9, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

DKK3 Overexpression Increases Malignant Properties of Head and Neck Squamous Cell Carcinoma Cells.
Authors: Katase N, Nishimatsu SI, Yamauchi A, Yamamura M, Terada K, Itadani M, Okada N, Hassan NMM, Nagatsuka H, Ikeda T, Nohno T, Fujita S Abstract DKK3, a member of dickkopf WNT signaling pathway inhibitor family, is believed to be a tumor suppressor, because of itsreduced expression in cancer cells. However, our previous studies have revealed that DKK3 expression is predominantly observed in head and neck, and oral squamous cell carcinoma (HNSCC/OSCC). Interestingly, HNSCC/OSCC patients with DKK3 expression showed high metastasis rate and poorer survival, and siRNA-mediated knockdown of DKK3 in HNSCC-derived can...
Source: Oncology Research - May 6, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MicroRNA-138 Inhibits Cell Growth, Invasion, and EMT of Non-Small Cell Lung Cancer Via SOX4/p53 Feedback Loop.
In this study, we investigated the biological functions and molecular mechanisms of miR-138 in NSCLC cell lines, discussing whether it could be a therapeutic biomarker of NSCLC in the future. In our study, we found that miR-138 is down-regulated in NSCLC tissues and cell lines. Moreover, the low level of miR-138 was associated with increased expression of SOX4 in NSCLC tissues and cell lines. Up-regulation of miR-138 significantly inhibited proliferation of NSCLC cells. In addition, invasion and EMT of NSCLC cells was suppressed by overexpression of miR-138. However, down-regulation of miR-138 promoted cell growth and meta...
Source: Oncology Research - June 28, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Activation of Vimentin is Critical to Promote a Metastatic Potential of Cholangiocarcinoma Cells.
Authors: Saentaweesuk W, Araki N, Vaeteewoottacharn K, Silsirivanit A, Seubwai W, Talabnin C, Muisuk K, Sripa B, Wongkham S, Okada S, Wongkham C Abstract Cholangiocarcinoma (CCA) is a highly metastatic tumor, of which the majority of the patients have short survival due tono effective treatment. Hence, a better understanding regarding CCA metastasis may provide an opportunity to improve the strategies for treatment. A comparison study between the highly metastatic cells and their parental cells is an approach to uncover the molecular mechanisms underlying the metastatic process. In the present study, a lung metasta...
Source: Oncology Research - August 3, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiR-449a Suppresses LDHA-Mediated Glycolysis to Enhance the Sensitivity of Non-Small Cell Lung Cancer Cells to Ionizing Radiation.
Authors: Li L, Liu H, Du L, Xi P, Wang Q, Li Y, Liu D Abstract MicroRNA dysregulation contributes to malignant progression, dissemination and profound treatment resistance in multiple cancers. MiR-449a is recognized as a tumor suppresser. However, roles of miR-449a in lung cancers initiation and progression are largely unrevealed. Our study aims to investigate roles and the underlying mechanism of miR-449a in modulating sensitivity to ionizing radiation (IR) in non-small cell lung cancers (NSCLC). Lung cancer cells were transfected with miR-449a mimics or negative control and exposed to IR, levels of target protein...
Source: Oncology Research - August 14, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiR-26b Mimic Inhibits Glioma Proliferation In Vitro and In Vivo Suppressing COX-2 Expression.
Authors: Chen ZG, Zheng CY, Cai WQ, Li DW, Ye FY, Zhou J, Wu R, Yang K Abstract Glioma is the most common malignant tumor of the nervous system. Studies have shown the microRNA (miR)-26b/cyclooxygenase (COX)-2 axis in the development and progression in many tumor cells. Our study aims to investigate the effect and mechanism of miR-26b/COX-2 axis in glioma. Decreased expression of miR-26b with increased level of COX-2 was found in glioma tissues compared with matched normal tissues. A strong negative correlation was observed between the level of miR-26b and COX-2 in 30 glioma tissues. The miR-26b was then overexpres...
Source: Oncology Research - August 14, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Non-SMC Condensin I Complex, Subunit G (NCAPG) is a Novel Mitotic Gene Required for Hepatocellular Cancer Cell Proliferation and Migration.
Authors: Zhang Q, Su R, Shan C, Gao C, Wu P Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Currently, only chemoembolization and sorafenib have shown survival benefits for advanced HCC. There are major unmet needs in HCC management and the discovery of new therapeutic targets. Here, we identified that NCAPG(non-SMC condensin I complex, subunit G) as a novel mitotic gene required for HCC cell proliferation and migration through siRNA knockdown of a panel of novel overexpressed genes in HCC based on The Cancer Genome Atlas (TCGA) dataset. We found that knockdow...
Source: Oncology Research - October 20, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiR-136 inhibits malignant progression of hepatocellular carcinoma cells by targeting cyclooxygenase 2.
In conclusion, miR-136 was vital in the regulation of HCC cell proliferation and metastasis by targeting COX2. Thus, our findings provided novel evidence that miR-136 might be recommended as a potential target for the diagnosis and treatment of HCC patients. PMID: 29295728 [PubMed - as supplied by publisher]
Source: Oncology Research - January 5, 2018 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

The downregulation of miR-200c promotes lactate dehydrogenase A expression and non-small cell lung cancer progression.
This study was aimed to investigate the function and mechanism of microRNA-200c (miR-200c) in the progression of non-small cell lung cancer (NSCLC). A total of 76 patients diagnosed as NSCLC were enrolled in this study. Then, the expression level of miR-200c in NSCLC tissues and cell lines was investigated using the quantitative realtime polymerase chain reaction (RT-qPCR) method. We found the expression of miR200c was significantly reduced in NSCLC tissues and cell lines compared with in normal lung tissues and human bronchial epithelial cell line. Force the expression of miR-200c using miR-200c mimic significantly suppre...
Source: Oncology Research - January 14, 2018 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

CD47 promotes human glioblastoma invasion through activation of PI3K/Akt pathway.
In this study we found that CD47 expression was stronger in glioblastoma patients and cells in comparison with normal controls. CD47 downregulation modulated by siRNA suppressed invasion in vitro. However, excessive CD47 expression modulated by transfection exerted opposite influence. In the meantime, excessive CD47 or knockdown CD47 expression had no effect on proliferation. Moreover, CD47 expression was related to AKT phosphorylation on cellular molecular level. AKT suppression with specific inhibitor impaired invasion of cells in which excessively expressed CD47, indicating that stimulation of PI3K/Akt pathway served as...
Source: Oncology Research - January 14, 2018 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Pages: 1  2  3  4  5  6  7  8