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HNF4α contributes to glucose formation in aged rat hepatocytes.
This study suggests that the mild hypoxic conditions in response to aging-dependent hepatic structural changes may contribute to the induction of the gluconeogenic enzyme PEPCK through HNF4α protein stabilization. PMID: 24177414 [PubMed - as supplied by publisher]
Source: Experimental Gerontology - October 29, 2013 Category: Geriatrics Authors: Park EY, Lee CH, Lee EK, Kim JH, Cova A, Lee SK, Cho SC, Kwak CS, Song KY, Park SC, Jun HS, Kim KT Tags: Exp Gerontol Source Type: research

Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats.
Abstract Adipogenesis and lipid accumulation during aging have a great impact on the aging process and the pathogenesis of chronic, age-related diseases. However, little is known about the age-related molecular changes in lipid accumulation and the mechanisms underlying them. Here, using 5-month- and 25-month-old rats (young and old, respectively), we found that epididymal fat is the only tissue to accumulate during aging. By testing tissues rich with mitochondria in old and young animals, we found that the old animals had elevated levels of triglycerides in their muscle, heart and liver tissues but not in their k...
Source: Experimental Gerontology - February 8, 2014 Category: Geriatrics Authors: Zhao L, Zou X, Feng Z, Luo C, Liu J, Li H, Chang L, Wang H, Li Y, Long J, Gao F, Liu J Tags: Exp Gerontol Source Type: research

Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis.
In this study, we show for the first time that the protein level of plasminogen activator inhibitor 1 (PAI-1), a protease inhibitor which plays an essential role in the control of fibrinolysis, was significantly increased with age in mouse lung homogenate and lung fibroblasts. Upon bleomycin challenge, old mice experienced augmented PAI-1 induction and lung fibrosis as compared to young mice. Most interestingly, we show that fewer (myo)fibroblasts underwent apoptosis and more (myo)fibroblasts with increased level of PAI-1 accumulated in the lung of old than in young mice after bleomycin challenge. In vitro studies further ...
Source: Experimental Gerontology - November 28, 2014 Category: Geriatrics Authors: Huang WT, Akhter H, Jiang C, MacEwen M, Ding Q, Antony V, Thannickal VJ, Liu RM Tags: Exp Gerontol Source Type: research

Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway.
This study confirmed that glucose restriction can enhance autophagy, inhibit senescence, and enhance proliferation of HUVECs through the AMPK/SIRT1-FOXA3-Beclin1 pathway. PMID: 32768436 [PubMed - as supplied by publisher]
Source: Experimental Gerontology - August 4, 2020 Category: Geriatrics Authors: Liu Q, Li H, Wang J, Zhong L, Chen X, Zhang R, Wang H Tags: Exp Gerontol Source Type: research

Changes in AMPK activity induces cellular senescence in human dental follicle cells
This study examined the role of AMPK in inducing senescence in DFCs. During the induction of cellular senescence, AMPK activity was impaired, suggesting a negative impact on senescence induction. In line with this assumption, cellular senescence was induced upon inhibition of AMPK with a specific siRNA. In addition, after this inhibition, autophagy was also inhibited. Moreover, specific inhibition of autophagy promoted cellular senescence. However, inducers of AMPK such as metformin or AICAR surprisingly increased senescence in DFCs. Interestingly, autophagy was impaired after long-term induction of AMPK with AICAR and met...
Source: Experimental Gerontology - December 23, 2022 Category: Geriatrics Authors: Christian Morsczeck Anja Reck Torsten E Reichert Source Type: research

Osteocalcin inhibits myocyte aging through promotion of starvation-induced autophagy via IL-6/STAT3 signaling
In conclusion, the inhibition of osteocalcin on muscle cell aging is accompanied by the induction of IL-6-STAT3-dependent autophagy, indicating osteocalcin might be a promising therapeutic candidate for aging-related myopathies.PMID:36621698 | DOI:10.1016/j.exger.2023.112082
Source: Experimental Gerontology - January 9, 2023 Category: Geriatrics Authors: Pengying Gu Daidi Tao Yuanyuan Xu Qian Yang Tingting Bai Shilian Hu Xingyuan Yang Source Type: research