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Source: Cytokine
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Total 53 results found since Jan 2013.
Quercetin protects against Aspergillus fumigatus keratitis by reducing fungal load and inhibiting TLR-4 induced inflammatory response
CONCLUSION: Quercetin plays a protective role in mouse A. fumigatus keratitis by inhibiting fungal load, disrupting hyphae structure, macrophage infiltration, and suppressing inflammation response in macrophages via TLR-4 mediated signaling pathway.PMID:37677994 | DOI:10.1016/j.cyto.2023.156356
Source: Cytokine - September 7, 2023 Category: Molecular Biology Authors: Junjie Luan Yunan Zhu Jing Lin Yingxue Zhang Qiang Xu Lu Zhan Xue Tian Guiqiu Zhao Xudong Peng Source Type: research
IL-17 upregulates MCP-1 expression via Act1 / TRAF6 / TAK1 in experimental autoimmune myocarditis
This study aimed to explore the role of Act1/TRAF6/TAK1 cascade in IL-17-induced MCP-1 expression based on a well-designed experimental autoimmune myocarditis (EAM) model. It was found that IL-17 could stimulate the expression of MCP-1 by activating Act1/TRAF6/TAK1 cascade in EAM. The expression of Act1, TRAF6 and TAK1 followed downregulation by the application of IL-17 antibody. Additionally, myocardial inflammatory cell infiltration was observably alleviated by interfering TAK1 with TAK1 siRNA, and both MCP-1 mRNA and protein expression followed downregulation. This study suggested that IL-17 could activate the Act1/TRAF...
Source: Cytokine - February 20, 2022 Category: Molecular Biology Authors: Xiao Huang Zhuolun Li Xinhe Shen Na Nie Yan Shen Source Type: research
Hypertensive effects of transforming growth factor- β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2
In this study, we examined the role of extracellular sulfatases on TGF-β1-induced effects associated with the expression of mediators related to hypertension in vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHR). First, TGF-β1 increased the expression of 12-lipoxygenase (12-LO) and endothelin-1 (ET-1), inhibited dimethylarginine dimethylaminohydrolase-1 (DDAH-1) expression and showed additive effects on Ang II-induced 12-LO and ET-1 expression as well as Ang II-induced inhibition of DDAH-1 expression in SHR VSMCs. However, it had no effect on the expression of 12-LO, ET-1, and DDAH-1 in VSMCs...
Source: Cytokine - November 22, 2021 Category: Molecular Biology Authors: Hee Sun Kim Hye Young Kim Source Type: research
The tumor necrosis factor family molecules LIGHT and lymphotoxins in sinus mucosa of patients with chronic rhinosinusitis with or without nasal polyps
CONCLUSIONS: LIGHT and LTs may participate in the ongoing process of chronic inflammation, inducing chemokine secretion, leukocyte migration, and dysregulated epithelial barrier through LTβR and HVEM in sinonasal mucosa.PMID:34083106 | DOI:10.1016/j.cyto.2021.155594
Source: Cytokine - June 4, 2021 Category: Molecular Biology Authors: Jae Woong Hwang Young Chan Kim Ho Young Lee Ki Jeong Lee Tae Hoon Kim Sang Hag Lee Source Type: research
Mini-TrpRS is essential for IFN γ-induced monocyte-derived giant cell formation
Cytokine. 2021 Mar 12;142:155486. doi: 10.1016/j.cyto.2021.155486. Online ahead of print.ABSTRACTTruncated tryptophanyl-tRNA synthetase (mini-TrpRS), like any other aminoacyl-tRNA synthetases, canonically functions as a protein synthesis enzyme. Here we provide evidence for an additional signaling role of mini-TrpRS in the formation of monocyte-derived multinuclear giant cells (MGCs). Interferon-gamma (IFNγ) readily induced monocyte aggregation leading to MGC formation with paralleled marked upregulation of mini-TrpRS. Small interfering (si)RNA, targeting mini-TrpRS in the presence of IFNγ prevented monocyte aggregation....
Source: Cytokine - March 15, 2021 Category: Molecular Biology Authors: Erik Biros Venkat Vangaveti Corey S Moran Source Type: research
p53 affects epigenetic signature on SOCS1 promoter in response to TLR4 inhibition.
Abstract
Suppressor of cytokine signaling (SOCS1) functions as a negative regulator of toll-like receptor (TLR) induced inflammatory signaling. As silencing of SOCS1 is concomitant with elevated TLR4 levels in glioblastoma, we investigated the effect of TLR4 inhibition on SOCS1 expression. Pharmacological inhibition of TLR4 signaling by TAK242 or its siRNA-mediated knockdown in p53 mutant or wild-type glioma cells resulted in either increased or decreased SOCS1 expression and promoter activity, respectively. Genetic manipulation of p53 indicated that SOCS1 expression upon TLR4 inhibition is dependent on p53 mutati...
Source: Cytokine - January 18, 2021 Category: Molecular Biology Authors: Sheikh T, Sen E Tags: Cytokine Source Type: research
In cardiac fibroblasts, interferon-beta attenuates differentiation, collagen synthesis, and TGF- β1-induced collagen gel contraction.
In conclusion, IFN-β through STAT1 and STAT2 shows antifibrotic effects on CF TGF-β1-treated, whereas STAT3 did not participate in such effect.
PMID: 33160814 [PubMed - as supplied by publisher]
Source: Cytokine - November 4, 2020 Category: Molecular Biology Authors: Bolivar S, Espitia-Corredor JA, Olivares-Silva F, Valenzuela P, Humeres C, Anfossi R, Castro E, Vivar R, Salas-Hernández A, Pardo-Jiménez V, Díaz-Araya G Tags: Cytokine Source Type: research
