In cardiac fibroblasts, interferon-beta attenuates differentiation, collagen synthesis, and TGF- β1-induced collagen gel contraction.

In conclusion, IFN-β through STAT1 and STAT2 shows antifibrotic effects on CF TGF-β1-treated, whereas STAT3 did not participate in such effect.
PMID: 33160814 [PubMed - as supplied by publisher]

Source: Cytokine - November 4, 2020 Category: Molecular Biology Authors: Bolivar S, Espitia-Corredor JA, Olivares-Silva F, Valenzuela P, Humeres C, Anfossi R, Castro E, Vivar R, Salas-Hernández A, Pardo-Jiménez V, Díaz-Araya G Tags: Cytokine Source Type: research