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Effect of expression of PPARG, DNM2L, RRAD, and LINGO1 on broiler chicken breast muscle satellite cell function
The objective of this study was to determine the expression of the adipogenic genes PPARG, DNM2L, RRAD, and LINGO1 in commercial Ross 708 (708) and Randombred (RBch) satellite cells. RBch satellite cells are from commercial 1995 broilers before WB and 708 broilers are a modern commercial line. In general, expression of these genes was different between the 708 and RBch satellites during proliferation and differentiation. Expression of PPARG and RRAD were both significantly increased during both proliferation and differentiation in the 708 cells (P ≤ 0.05). Knocking down the expression of these genes with small interferin...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - March 12, 2022 Category: Physiology Authors: Sandra G Velleman Cynthia S Coy Behnam Abasht Source Type: research

Effect of growth selection of broilers on breast muscle satellite cell function: Response of satellite cells to NOV, COMP, MYBP-C1, and CSRP3.
Abstract The wooden breast (WB) myopathy is characterized by the palpation of a hard pectoralis major muscle that results in the necrosis and fibrosis of muscle fibers in fast-growing heavy weight meat-type broiler chickens. Necrosis of existing muscle fibers requires the repair and replacement of these myofibers. Satellite cells are responsible for the repair and regeneration of myofibers. To address how WB affects satellite cell function, top differentially expressed genes in unaffected and WB-affected pectoralis major muscle determined by RNA-Sequencing were studied by knocking down their expression by small in...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - February 3, 2021 Category: Physiology Authors: Velleman SG, Coy CS, Abasht B Tags: Comp Biochem Physiol A Mol Integr Physiol Source Type: research