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Source: Cell Biology International
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Total 159 results found since Jan 2013.
Lefty Promotes the Proliferation and Invasion of Trophoblast Cells by Inhibiting Nodal Expression.
Abstract
Trophoblast cells play a vital role in embryo implantation. Exploring cytokines secreted by trophoblast cells will be significant in revealing the molecular mechanism of embryo implantation. In vitro-cultured trophoblast cells treated with Lefty revealed that Lefty could downregulate the expression of Nodal while promoting the expression of MMP-2 and MMP-9. Thus, Lefty may promote the proliferation and invasion of trophoblast cells, thereby reducing the amount of apoptosis of these cells. Lefty siRNA knockdown or overexpression of Nodal showed opposite effects to treatment with Lefty. When trophoblast cel...
Source: Cell Biology International - April 16, 2018 Category: Cytology Authors: Li H, Cao R, Bai L, Qiao XM, Zhao YQ Tags: Cell Biol Int Source Type: research
TRIM22 knockdown suppresses chronic myeloid leukemia via inhibiting PI3K/Akt/mTOR signaling pathway.
In conclusion, loss of TRIM22 suppresses the progression and invasion of CML through regulation of PI3K/Akt/mTOR pathway, suggesting that TRIM22 might be as a potential target for the treatment strategy of CML.
PMID: 29762880 [PubMed - as supplied by publisher]
Source: Cell Biology International - May 15, 2018 Category: Cytology Authors: Li L, Qi Y, Ma X, Xiong G, Wang L, Bao C Tags: Cell Biol Int Source Type: research
Dexmedetomidine protects hepatic cells against oxygen-glucose deprivation/reperfusion injury via lncRNA CCAT1.
This study suggests a novel role of CCAT1 in ischemia reperfusion injury, and lays the framework for future studies.
PMID: 29851220 [PubMed - as supplied by publisher]
Source: Cell Biology International - May 30, 2018 Category: Cytology Authors: Zhou Z, Chen Q, Wan L, Zheng D, Li Z, Wu Z Tags: Cell Biol Int Source Type: research
Lipopolysaccharide induced the proliferation of mouse lung fibroblasts by suppressing FoxO3a/p27 pathway.
Abstract
Aberrant aggregation and activation of lung fibroblasts is a key process in pulmonary fibrosis, but the underlying mechanism remains enigmatic. Forkhead Box O3a (FoxO3a) is considered to be an important transcription factor that could regulate both cell cycle and cell viability. To investigate the role of FoxO3a on LPS-induced lung fibroblast proliferation, we transfected FoxO3a-SiRNA or FoxO3a-OE lentivirus into cultured mouse lung fibroblasts to knockdown or overexpress FoxO3a and pretreated mouse lung fibroblasts with gefitinib to enhance FoxO3a activity. The proliferation of lung fibroblasts was evalu...
Source: Cell Biology International - June 16, 2018 Category: Cytology Authors: Gu N, Xing S, Chen S, Zhou Y, Jiang T, Jiao Y, Gao Y, Yu W, He Z, Wen D Tags: Cell Biol Int Source Type: research
Aggravated Intestinal Apoptosis by ClC-3 Deletion is Lethal to Mice Endotoxemia.
Abstract
Our previous study found that ClC-3 chloride channel functioned differently in the vascular and intestinal inflammation, the loss of ClC-3 reduced vascular inflammation but exacerbated intestinal inflammation. To furtherly clarify the role of ClC-3 chloride channels in systemic inflammation, we used LPS-induced endotoxemia model to investigate the response of wild-type and ClC-3 knockout mice to systemic inflammation. The results showed that in the LPS-induced endotoxemia model, the mortality of mice with ClC-3 deletion was significantly higher than that of wild-type mice. The liver and lung inflammations...
Source: Cell Biology International - July 4, 2018 Category: Cytology Authors: Huang LY, Li YJ, Li PP, Li HC, Ma P Tags: Cell Biol Int Source Type: research
Bcl6 knockdown aggravates hypoxia injury in cardiomyocytes via the P38 pathway.
This study was designed to determine whether Bcl6 affects hypoxia-induced cardiomyocyte injury and, if so, to identify the underlying mechanism. To meet this aim, cardiomyocytes were exposed to hypoxia and Bcl6 siRNA was used to silence Bcl6 in cardiomyocytes. Bcl6 knockdown under physiological conditions caused increased oxidative stress, apoptosis, and expression of pro-inflammatory cytokines. Increased inflammatory response, oxidative stress, and apoptosis were observed after cells were exposed to hypoxia for 24 h. Bcl6 knockdown aggravated cardiomyocyte injury when exposed to hypoxia. Bcl6 knockdown increased P38 act...
Source: Cell Biology International - July 4, 2018 Category: Cytology Authors: Gu Y, Luo M, Li Y, Su Z, Wang Y, Chen X, Zhang S, Sun W, Kong X Tags: Cell Biol Int Source Type: research
TRIM65 is a potential oncogenic protein via ERK1/2 on Jurkat and Raji cells: a therapeutic target in human lymphoma malignancies.
Abstract
In human lung cancer, Tripartite motif 65 (TRIM65) is documented as an important regulator in carcinogenesis. Knockdown of TRIM65 prevents the tumorigenesis of lung cancer cells, while TRIM65 overexpression presents the opposite effect. However, the roles of TRIM65 in human lymphocyte malignancies have reported little. Herein, we found that Jurkat (T-lymphocyte) and Raji (B-lymphocyte) expressed TRIM65. We aimed to investigate whether TRIM65 was a potential oncogenic protein that regulated the tumorigenesis of Jurkat and Raji cells. In our present study, cells were transfected with siRNA-TRIM65 or TRIM65 ...
Source: Cell Biology International - July 24, 2018 Category: Cytology Authors: Wang J, Liang X, Yu T, Xu YL, Xu LH, Zhang XJ, Ma J, Wang YR, He SL Tags: Cell Biol Int Source Type: research
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
In conclusion, we find that down-regulation of lncRNA induces autophagy and inhibited the proliferation, migration and invasion by AKT/mTOR signaling pathway in HCAECs.
PMID: 30536541 [PubMed - as supplied by publisher]
Source: Cell Biology International - December 11, 2018 Category: Cytology Authors: Zhang X, Liu J, Gu Y, Sun C, Qu F Tags: Cell Biol Int Source Type: research
The Hippo-YAP Pathway Regulates the Proliferation of Alveolar Epithelial Progenitors after Acute Lung Injury.
Abstract
Regeneration of pulmonary epithelial cells plays an important role in the recovery of acute lung injury (ALI) which is defined by pulmonary epithelial cell death. However, the mechanism of the regenerative capacity of alveolar epithelial cells is unknown. Using a lung injury mouse model induced by hemorrhagic shock and LPS, a protein mass spectrometry-based high-throughput screening and linage tracing technology to mark alveolar epithelial type 2 cells (AEC2s), we analyzed the mechanism of alveolar epithelial cells proliferation. We demonstrated that the expression of Hippo-YAP1 (Yes-associated protein 1)...
Source: Cell Biology International - January 11, 2019 Category: Cytology Authors: Hu C, Sun J, Du J, Wen D, Lu H, Zhang H, Xue Y, Zhang A, Yang C, Zeng L, Jiang J Tags: Cell Biol Int Source Type: research
Periostin plays role in force-induced stem cell potential by periodontal ligament stem cells.
This study suggests a proper magnitude of compressive force could be one important factor involved in the modulation of the pluripotency of PDLSCs through the action of periostin. The precise mechanism by which periostin regulates stemness requires further detailed investigation.
PMID: 30761669 [PubMed - as supplied by publisher]
Source: Cell Biology International - February 13, 2019 Category: Cytology Authors: Panchamanon P, Pavasant P, Leethanakul C Tags: Cell Biol Int Source Type: research
Role of PLD-PKC ζ signalling axis in p47phox phosphorylation for activation of NADPH oxidase by angiotensin II in pulmonary artery smooth muscle cells.
This article is protected by copyright. All rights reserved.
PMID: 30977575 [PubMed - as supplied by publisher]
Source: Cell Biology International - April 11, 2019 Category: Cytology Authors: Chakraborti S, Sarkar J, Chakraborti T, Chakraborti S Tags: Cell Biol Int Source Type: research
MicroRNA-144-3p Suppressed TGF- β1-induced Lung Cancer Cell Invasion and Adhesion via Regulating Src-Akt-Erk Pathway.
This study aimed to study the mechanisms underlying miR-144-3p inhibiting lung cancer. The expression levels of miR-144-3p and steroid receptor coactivator (Src) in different lung cancer cell lines and those in bronchial epithelial cells (16HBE) were compared. MiR-144-3p mimic and siSrc were transfected into A549 cells. Under the conditions of transforming growth factor-β1 (TGF-β1) siRNA transfection or TGF-β1 treatment, cell invasive and adhesive abilities were analyzed by Transwell and cell adhesion assays. miR-144-3p inhibitor and siSrc were co-transfected into A549 cells and the changes in cell invasion and adhesion...
Source: Cell Biology International - April 29, 2019 Category: Cytology Authors: Jiang W, Dong Y, Yu L, Che J, Zhang J, Yang J Tags: Cell Biol Int Source Type: research
Tripartite motif protein 52 (TRIM52) promoted fibrosis in LX-2 cells through PPM1A-mediated Smad2/3 pathway.
This article is protected by copyright. All rights reserved.
PMID: 31329338 [PubMed - as supplied by publisher]
Source: Cell Biology International - July 21, 2019 Category: Cytology Authors: Zhou J, Lan Q, Li W, Yang L, You J, Zhang YM, Ni W Tags: Cell Biol Int Source Type: research
Role of km23-1 in Ras/ERK regulationkm23-1/DYNLRB1 regulation of MEK/ERK signaling and R-Ras in invasive human colorectal cancer cells.
This article is protected by copyright. All rights reserved.
PMID: 31393067 [PubMed - as supplied by publisher]
Source: Cell Biology International - August 7, 2019 Category: Cytology Authors: Raza A, Pandey MS, Jin Q, Mulder KM Tags: Cell Biol Int Source Type: research
Transcription factor E2F4 is a positive regulator of milk biosynthesis and proliferation of bovine mammary epithelial cells.
This article is protected by copyright. All rights reserved.
PMID: 31475773 [PubMed - as supplied by publisher]
Source: Cell Biology International - September 1, 2019 Category: Cytology Authors: Zhen Z, Zhang M, Yuan X, Li M Tags: Cell Biol Int Source Type: research
