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Specialty: Nanotechnology
Source: Journal of Nanobiotechnology
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Total 32 results found since Jan 2013.
Edible and cation-free kiwi fruit derived vesicles mediated EGFR-targeted siRNA delivery to inhibit multidrug resistant lung cancer
Clinically, activated EGFR mutation associated chemo-drugs resistance has severely threaten NSCLC patients. Nanoparticle based small interfering RNA (siRNA) therapy representing another promising alternative b...
Source: Journal of Nanobiotechnology - February 5, 2023 Category: Nanotechnology Authors: Haoying Huang, Xiaohan Yi, Qingyun Wei, Mengyuan Li, Xueting Cai, Yan Lv, Ling Weng, Yujie Mao, Weiwei Fan, Mengmeng Zhao, Zhongpei Weng, Qing Zhao, Kewei Zhao, Meng Cao, Jing Chen and Peng Cao Tags: Research Source Type: research
A pH-responsive metal-organic framework for the co-delivery of HIF-2 α siRNA and curcumin for enhanced therapy of osteoarthritis
The occurrence of osteoarthritis (OA) is highly correlated with the reduction of joint lubrication performance, in which persistent excessive inflammation and irreversible destruction of cartilage dominate the...
Source: Journal of Nanobiotechnology - January 17, 2023 Category: Nanotechnology Authors: Zi-Jian Zhang, Ying-Ke Hou, Ming-Wa Chen, Xue-Zhao Yu, Si-Yu Chen, Ya-Ru Yue, Xiong-Tian Guo, Jin-Xiang Chen and Quan Zhou Tags: Research Source Type: research
Combination of polythyleneimine regulating autophagy prodrug and Mdr1 siRNA for tumor multidrug resistance
Multidrug resistance (MDR) has been restricting the efficacy of chemotherapy, which mainly include pump resistance and non-pump resistance. In order to fight overall MDR, a novel targeted gene/drug co-deliver ...
Source: Journal of Nanobiotechnology - November 11, 2022 Category: Nanotechnology Authors: Changduo Wang, Zhipeng Li, Ping Xu, Lisa Xu, Shangcong Han and Yong Sun Tags: Research Source Type: research
Cytoplasmic delivery of siRNA using human-derived membrane penetration-enhancing peptide
Although protein-based methods using cell-penetrating peptides such as TAT have been expected to provide an alternative approach to siRNA delivery, the low efficiency of endosomal escape of siRNA/protein compl...
Source: Journal of Nanobiotechnology - October 27, 2022 Category: Nanotechnology Authors: Momoko Nakamura, Kei Fujiwara and Nobuhide Doi Tags: Research Source Type: research
Mesoporous silica-coated silver nanoparticles as ciprofloxacin/siRNA carriers for accelerated infected wound healing
The colonization of bacterial pathogens is a major concern in wound infection and becoming a public health issue. Herein, a core –shell structured Ag@MSN (silver core embedded with mesoporous silica, AM)-based ...
Source: Journal of Nanobiotechnology - August 23, 2022 Category: Nanotechnology Authors: Qiqi Liu, Ying Zhang, Jingkai Huang, Zhourui Xu, Xiang Li, Jingyu Yang, Haoqiang Huang, Shiqi Tang, Yujuan Chai, Jinbo Lin, Chengbin Yang, Jia Liu and Suxia Lin Tags: Research Source Type: research
Lipid-coated albumin-paclitaxel nanoparticles loaded with sorcin-siRNA reverse cancer chemoresistance via restoring intracellular calcium ion homeostasis
Chemoresistance is often a cause of the failure of chemotherapy in cancer treatment. Sorcin (SRI) is a soluble resistance-related calcium-binding protein involved in chemoresistant processes and is overexpress...
Source: Journal of Nanobiotechnology - July 7, 2022 Category: Nanotechnology Authors: Chenglong Wang, Xiaolin Xu, Peipei Zhang, Shuhan Xiong, Jia Yuan, Xuzhu Gao, Wencai Guan, Fanchen Wang, Xin Li, Hongjing Dou and Guoxiong Xu Tags: Research Source Type: research
IR792-MCN@ZIF-8-PD-L1 siRNA drug delivery system enhances photothermal immunotherapy for triple-negative breast cancer under near-infrared laser irradiation
Despite extensive investigations on photothermal therapy, the clinical application is restricted due to poor stability, low therapeutic efficacy of photothermal therapy agents and its affinity loss in the mult...
Source: Journal of Nanobiotechnology - March 2, 2022 Category: Nanotechnology Authors: Yongmei Wang, Haibo Wang, Yuhua Song, Meng Lv, Yan Mao, Hongming Song, Yuanyuan Wang, Gang Nie, Xiaoyi Liu, Jian Cui and Xueqing Zou Tags: Research Source Type: research
A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1)
Knocking down the oncogene ROC1 with siRNA inhibits the proliferation of cancer cells by suppressing the Neddylation pathway. However, methods for delivering siRNA in vivo to induce this high anticancer activi...
Source: Journal of Nanobiotechnology - October 15, 2021 Category: Nanotechnology Authors: Zhanxia Zhang, Junqian Zhang, Jianhui Tian and Hegen Li Tags: Research Source Type: research
Endogenous microRNA triggered enzyme-free DNA logic self-assembly for amplified bioimaging and enhanced gene therapy via in situ generation of siRNAs
Small interfering RNA (siRNA) has emerged as a kind of promising therapeutic agents for cancer therapy. However, the off-target effect and degradation are the main challenges for siRNAs delivery. Herein, an en...
Source: Journal of Nanobiotechnology - September 26, 2021 Category: Nanotechnology Authors: Qinghua Jiang, Shuzhen Yue, Kaixin Yu, Tian Tian, Jian Zhang, Huijun Chu, Zhumei Cui and Sai Bi Tags: Research Source Type: research
Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing
Excessive expression of matrix metalloproteinase 9 (MMP-9) impedes healing of diabetic chronic wounds, thus wound dressing that could effectively inhibit the expression of MMP-9 offers significant clinical tra...
Source: Journal of Nanobiotechnology - May 5, 2021 Category: Nanotechnology Authors: Biyun Lan, Liming Zhang, Liqun Yang, Junfeng Wu, Na Li, Chenglin Pan, Xiaoyi Wang, Lexiang Zeng, Li Yan, Chuan Yang and Meng Ren Tags: Research Source Type: research
Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small ‐molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids
siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, ...
Source: Journal of Nanobiotechnology - March 8, 2021 Category: Nanotechnology Authors: Ezgi Oner, Mustafa Kotmakci, Anne-Marie Baird, Steven G. Gray, Bilge Debelec Butuner, Emir Bozkurt, Ayse Gulten Kantarci and Stephen P. Finn Tags: Research Source Type: research
Au-siRNA@ aptamer nanocages as a high-efficiency drug and gene delivery system for targeted lung cancer therapy
Gene and chemical therapy has become one of the rising stars in the field of molecular medicine during the last two decades. However, there are still numerous challenges in the development of efficient, target...
Source: Journal of Nanobiotechnology - February 24, 2021 Category: Nanotechnology Authors: Yuming Yang, Yu Han, Qiuyang Sun, Jin Cheng, Caixia Yue, Yanlei Liu, Jie Song, Weilin Jin, Xianting Ding, Jes ús M. de la Fuente, Jian Ni, Xiaoqiang Wang and Daxiang Cui Tags: Research Source Type: research
Novel fusion peptide ‐mediated siRNA delivery using self‐assembled nanocomplex
Gene silencing using siRNA can be a new potent strategy to treat many incurable diseases at the genetic level, including cancer and viral infections. Treatments using siRNA essentially requires an efficient an...
Source: Journal of Nanobiotechnology - February 12, 2021 Category: Nanotechnology Authors: Yeong Chae Ryu, Kyung Ah Kim, Byoung Choul Kim, Hui-Min David Wang and Byeong Hee Hwang Tags: Research Source Type: research
Development of elastin-like polypeptide for targeted specific gene delivery in vivo
The successful deliveries of siRNA depend on their stabilities under physiological conditions because greater in vivo stability enhances cellular uptake and enables endosomal escape. Viral-based systems appear...
Source: Journal of Nanobiotechnology - January 17, 2020 Category: Nanotechnology Authors: Aena Yi, Dahye Sim, Young-Jin Lee, Vijaya Sarangthem and Rang-Woon Park Tags: Research Source Type: research
Efficient siRNA delivery and gene silencing using a lipopolypeptide hybrid vector mediated by a caveolae-mediated and temperature-dependent endocytic pathway
We developed a non-viral vector, a combination of HIV-1 Tat peptide modified with histidine and cysteine (mTat) and polyethylenimine, jetPEI (PEI), displaying the high efficiency of plasmid DNA transfection wi...
Source: Journal of Nanobiotechnology - January 22, 2019 Category: Nanotechnology Authors: Hironori Kasai, Kenji Inoue, Kentaro Imamura, Carlo Yuvienco, Jin K. Montclare and Seiichi Yamano Tags: Research Source Type: research
