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A Randomized Trial of Penicillin Skin Testing Versus 2-Step Direct Challenge for Penicillin Allergy During Pregnancy
Penicillins are first-line therapy for peripartum prophylaxis in Group B streptococcal-colonized women, making delabeling of PCN allergy in this population particularly important. There is scant data regarding the safety of direct challenges in penicillin-allergic pregnant women.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Allison Ramsey, S. Shahzad Mustafa Source Type: research

Alanine scanning of IgE-binding to the N-terminal epitope of Ara h 2 reveal critical amino acids
IgE binding to linear peptides of the N-terminal epitope (epitope 1: DRRCQSQLERAN) of Ara h 2 correlates with sensitivity to challenge in infants with peanut allergy and may be important for tree nut and peanut cross reactivity.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Joshua Bernstein, Nicole Canon, Catherine Schein, Werner Braun, Surendra Negi, Marina Pozzoli, Xueni Chen, Stephen Dreskin Source Type: research

Time to Resolution of Milk Allergy Utilizing Baked-Milk Diet
Sparse studies have investigated the issue of time-to-tolerance of milk allergy with the use of baked-milk diets and there is little evidence to support the idea that the ingestion of baked milk results in patients outgrowing their milk allergy. The goal of our study is to provide an analysis of the resolution of milk allergy utilizing a baked-milk diet and add to the scant data in this area.
Source: Journal of Allergy and Clinical Immunology - February 1, 2022 Category: Allergy & Immunology Authors: Jeff Zavala, Benjamin Davis, Erin Rasmussen Source Type: research

Alanine scans of IgE-binding to linear epitopes of Ara h 2 reveal critical amino acids
Important IgE-binding linear epitopes of Ara h 2 have been described but the core sequences and relative importance of individual amino acids have not been defined.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Nicole Canon, Catherine Schein, Xueni Chen, Marina Pozzoli, Vidhya Pathy, Stephen Dreskin Source Type: research

Eosinophil paradox with mepolizumab in chronic rhinosinusitis with nasal polyposis
We were intrigued to read the post hoc analysis by Howarth et  al1 suggesting that 100 mg mepolizumab given subcutaneously may reduce disease burden in the upper and lower airways of patients with severe eosinophilic asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP). Pointedly, the diagnosis of CRSwNP was not based on either sinonasal endoscopy or computed tomography scan. The subgroup of patients in the MUSCA trial who completed the 22-item Sino-Nasal Outcome Test (SNOT-22) exhibited a mean treatment effect of −11.8 with mepolizumab, which exceeded the minimal clinically important difference of −8.9.
Source: Journal of Allergy and Clinical Immunology - July 24, 2020 Category: Allergy & Immunology Authors: Brian Lipworth, Rory Chan, Chris RuiWen Kuo Tags: Correspondence Source Type: research

Characterization of patients with allergic reactions to iodinated contrast media during CT scan
We have recently reported that a considerable proportion of subjects diagnosed with allergy to iodinated contrast media (ICM) are in fact not allergic. This may lead to the unnecessary administration of pre-medication and delayed treatment or diagnostic studies. Further understanding of bona-fide systemic allergic responses is therefore required and here we aim to characterize the severity, precipitating factors and benefit of pre-medication in such reactions.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Aviv Talmon, Joshua Moss, Dorith Shaham, Yuval Tal, Alon Hershko Source Type: research

Allow Children to Speak Up For Their Own Healthcare
Effective communication in visits is essential for treatment adherence. Children with chronic diseases have low adherence, and their participation in their own visits is limited. Appointments are often dyadic in nature (between provider and patient). Scant research exists on provider communication with a child and their caregiver. We studied aspects of triadic interactions involving these three participants to improve communication, understanding, and treatment adherence.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Sunil Saini, Madeleine Mendoza, Brandon Tran, Kate Sweeny Source Type: research

The NASAL score: a novel murine radiologic grading score for sinus disease
Sinus disease in humans is diagnosed by symptoms, endoscopic findings, and radiologic measures of sinus opacification on computed tomography (CT) scan. The Lund-Mackay scoring system in humans is based on the degree of opacification of each sinus. There have been several reports of murine models of sinusitis based on histopathologic and radiologic findings. To our knowledge, there are no published murine sinus scoring systems. We propose a novel NASAL score based on opacification levels of the individual sinuses in mice.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Eugene Chang Source Type: research

Decreased Airway Tone Measured by Impulse Oscillometry Identifies Concurrent Tracheobronchomalacia in Children with Asthma
Children with asthma who have concurrent tracheobronchomalacia (TBM) often require additional treatments to assist with airway clearance during an exacerbation. Current diagnostic methods for TBM are invasive and effort-dependent, ie. bronchoscopy and dynamic CT scan with forced expiration. We hypothesized that impulse oscillometry (IOS), a noninvasive and effort-independent modality to measure airway resistance and tone may be useful in diagnosing tracheobronchomalacia in children with asthma.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Yoomie J. Lee, Nathan Rabinovitch Source Type: research

Endotype-driven care pathways in patients with chronic rhinosinusitis
Chronic rhinosinusitis (CRS) has been differentiated clinically into CRS without nasal polyps and CRS with nasal polyps, with both forms subjected to glucocorticosteroid and antibiotic treatments and, if not successful, to nasal and sinus surgery tailored to endoscopic and computed tomographic scan findings. The elaboration of endotypes based on pathomechanisms involving different immune responses offers new possibilities in terms of prediction of prognosis and risks and sophisticated guidance in personalized pharmacotherapy, surgical approaches, and innovative treatment approaches in the CRS field with various biologics.
Source: Journal of Allergy and Clinical Immunology - May 1, 2018 Category: Allergy & Immunology Authors: Claus Bachert, Nan Zhang, Peter W. Hellings, Jean Bousquet Tags: Reviews and feature article Source Type: research

CD40 ligand deficiency causes functional defects of peripheral neutrophils that are improved by exogenous IFN- γ
Neutrophils from CD40L-deficient patients exhibit defective development and function that suggest an important role of CD40L-CD40 interaction for neutrophil maturation. These defects improve following in vitro exposure to rhIFN- γ.
Source: Journal of Allergy and Clinical Immunology - March 5, 2018 Category: Allergy & Immunology Authors: Otavio Cabral-Marques, Tabata Takahashi Fran ça, Ashraf Al-Sbiei, Lena Friederike Schimke, Taj Ali Khan, Claudia Feriotti, Tania Alves da Costa, Osvaldo Reis Junior, Cristina Worm Weber, Janaíra Fernandes Ferreira, Fabiola Scancetti Tavares, Claudia Val Source Type: research

Impact of Choosing Wisely on Antibiotic Prescription and CT Scan Use for Uncomplicated Acute Rhinosinusitis (ARS)
Earlier this decade, American Board of Internal Medicine Foundation along with Consumer Reports, launched the Choosing Wisely campaign with goal to encourage conversations between clinicians and patients to choose care that is evidence based, non-duplicative, free from harm and truly necessary. Multiple medical societies recommend against prescribing antibiotics and/or performing CT scans in uncomplicated acute rhinosinusitis. Purpose of this study was to evaluate trends in antibiotic prescription and CT scan order for uncomplicated acute rhinosinusitis before and after Choosing Wisely publication.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Hardik Patel, Wei Zhang, Yong-fang Kuo, Gulshan Sharma Source Type: research

Increased IL-13 expression is independently associated with neo-osteogenesis in patients with chronic rhinosinusitis
Chronic rhinosinusitis (CRS) is a multifactorial inflammatory disease of the paranasal sinus mucosa and might also involve  underlying bone, inducing new bone formation. Neo-osteogenesis has been thought to be a possible contributing factor to the pathophysiology of CRS, especially in the recalcitrant group of patients. It can be recognized as areas of increased thickness of the sinus bone, with the overlying sinus lin ing being irregular on computed tomographic (CT) scans.1,2 Associations between the inflammatory process and neo-osteogenesis in patients with CRS have been previously established3; however, no studies have...
Source: Journal of Allergy and Clinical Immunology - June 7, 2017 Category: Allergy & Immunology Authors: Sakiko Oue, Mahnaz Ramezanpour, Sathish Paramasivan, Dijana Miljkovic, Clare M. Cooksley, Ahmed Bassiouni, Judy Ou, Alkis J. Psaltis, Peter-John Wormald, Sarah Vreugde Tags: Letter to the Editor Source Type: research

Using imaging as a biomarker for asthma
There have been significant advancements in the various imaging techniques being used for the evaluation of asthmatic patients, both from a clinical and research perspective. Imaging characteristics can be used to identify specific asthmatic phenotypes and provide a more detailed understanding of endotypes contributing to the pathophysiology of the disease. Computed tomography, magnetic resonance imaging, and positron emission tomography can be used to assess pulmonary structure and function. It has been shown that specific airway and lung density measurements using computed tomography correlate with clinical parameters, i...
Source: Journal of Allergy and Clinical Immunology - December 31, 2016 Category: Allergy & Immunology Authors: Abhaya Trivedi, Chase Hall, Eric A. Hoffman, Jason C. Woods, David S. Gierada, Mario Castro Tags: Reviews and feature article Source Type: research

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