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Mechanisms of airway disease development following inhalation exposure to indoor fungal contaminants Stachybotrys chartarum and Aspergillus versicolor
Fungi are found ubiquitously in the environment and chronic repeated exposures have been associated with pulmonary and cognitive effects in humans. Previous studies have shown that two prominent indoor fungal contaminants, Stachybotrys chartarum and Aspergillus versicolor, are associated with allergic airway disease, airway remodeling, and Th2-mediated immunological effects. To understand the mechanisms of disease development, genetically modified murine models are an invaluable tool.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Catherine Blackwood, Angela Lemons, Rachael Rush, Walter McKinney, Dori Germolec, Donald Beezhold, Brett Green, Tara Croston Source Type: research

LABP-73: A Novel NLRX1 Ligand for the Treatment of Chronic Asthma
NLRX1 is a negative regulatory NOD-like receptor that has previously been shown to be protective against multiple respiratory diseases, including chronic obstructive pulmonary disease and fungal challenge with Aspergillus fumigatus. Activation of NLRX1, with the orally-active, gut-restricted first-in-class therapeutic, NX-13, has previously demonstrated an ability to control immunometabolism and to reduce Th17 differentiation and neutrophil recruitment while providing a favorable tolerability profile in the context of inflammatory bowel disease.
Source: Journal of Allergy and Clinical Immunology - February 1, 2022 Category: Allergy & Immunology Authors: Andrew Leber, Raquel Hontecillas, Nuria Tubau-Juni, Sarah Fitch, Sameeksha Alva, Jyoti Chauhan, Josep Bassaganya-Riera Source Type: research

Do Airborne Mold Counts Predict Asthma Exacerbations?
Airborne fungal spore counts including Alternaria, Cladiosporium, Ascospores, Aspergillus, Epicoccum, Agrocybe and Basidiospores have been correlated with asthma exacerbation requiring ER visits and hospitalizations in children and adults with asthma, particularly those sensitized to mold. Airborne fungi have also been suggested as a possible etiology for “thunderstorm asthma” driven more commonly by grass pollen. We hypothesized there would be a correlation between airborne mold and asthma exacerbations reflected in ER visits, nonurgent outpatient visits and hospitalization.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Kelsey Kaman, Christopher Randolph Source Type: research

MicroRNA-targeted proteomic profiling predicts potential biomarkers of Aspergillus versicolor exposure
Personal exposure to fungal bioaerosols within damp indoor environments is associated with adverse respiratory health effects. Pathway analysis of proteomic and RNA alterations following exposure to Aspergillus versicolor, a prominent indoor fungal contaminant, identified proteins and microRNAs not previously associated with fungal exposure.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Tara Croston, Mark Barnes, Angela Lemons, Dori Germolec, Donald Beezhold, Brett Green Source Type: research

Immune responses to repeated inhalation of Aspergillus versicolor conidia are driven and sustained by innate cell populations
In this study, a subchronic exposure model was used to assess the immunological effects following repeated A. versicolor conidia challenge.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Mark A. Barnes, Tara L. Croston, Angela R. Lemons, Donald H. Beezhold, Brett J. Green Source Type: research

Comparison of Proteomic Profiles Influencing Pulmonary Immune Responses Following Repeated Exposure to Aspergillus and Stachybotrys species
Adverse respiratory health effects have been associated with damp indoor environments and fungal contamination. Comparing molecular profiles following fungal exposures may help identify new biomarkers of fungal exposure.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Tara L. Croston, Mark A. Barnes, Angela R. Lemons, Ajay P. Nayak, Dori Germolec, Donald H. Beezhold, Brett J. Green Source Type: research

The Prevalence of Coexisting Allergies To Cladosporium And Aspergillus In A Pediatric Population
Fungal allergies are prevalent in the pediatric population with an impact on quality of life. In this category, Cladosporium and Aspergillus are two of the most common mold allergens. We hypothesized that most patients who had a Cladosporium allergy would also be allergic to Aspergillus.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Niharika Rath, Charles S. Barnes, Brian Lee, Neha N. Patel Source Type: research

Identification of Immuno-Reactive Proteins and Study of Immunogenic Peptides of the Major Allergen of Aspergillus terreus
This study is aimed to identify the allergens and determine their allergenic potency through immuno-biochemical methods from A. terreus, the most prevalent airborne allergenic fungus in West Bengal, India.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Bijoya Karmakar, Swati Gupta Bhattacharya Source Type: research

Aspergillus fumigatus IgG level greater than 60 mg/L Increases Diagnostic Specificity of Allergic Bronchopulmonary Aspergillosis
The Modified ISHAM (International Society for Human and Animal Mycology) working group 2013 criteria for diagnosis of allergic bronchopulmonary aspergillosis (ABPA) does not specify a cut-off value for specific IgG anti-Aspergillus fumigatus.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Sujoy Khan, Sushmita R. Chowdhury, Stephen Holding Source Type: research

Combination anti-IgE and anti-IL5 therapies in patients with severe persistent asthma and allergic bronchopulmonary aspergillosis (ABPA)
Many patients with severe persistent asthma have evidence of both Th2 and eosinophilic inflammation. This is often seen in ABPA with IgE levels>1000 U/mL and peripheral eosinophil counts>500 cells/mL, however, can also be seen without aspergillus sensitization. The optimal approach to steroid-sparing biologic therapy in such patients is unclear, and many continue to have active disease after a single biologic therapy is initiated.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Jay Patel, Andrew G. Ayars, Lahari Rampur, Stephen Bronson, Matthew C. Altman Source Type: research

Eosinophils release extracellular DNA traps in response to Aspergillus fumigatus
Extracellular DNA traps, commonly found in mucus plugs of patients with allergic bronchopulmonary aspergillosis, are released by eosinophils in response to Aspergillus fumigatus
Source: Journal of Allergy and Clinical Immunology - September 21, 2017 Category: Allergy & Immunology Authors: Valdirene S. Muniz, Juliana C. Silva, Yasmim A.V. Braga, Rossana C.N. Melo, Shigeharu Ueki, Masahide Takeda, Akira Hebisawa, Koichiro Asano, Rodrigo T. Figueiredo, Josiane S. Neves Source Type: research

Aspergillus fumigatus alkaline protease 1 (Alp1/Asp f13) in the airways correlates with asthma severity
A fungal protease (Alp1/Asp f13) from Aspergillus fumigatus was detected in the airways of subjects with asthma but not controls, which correlated strongly with disease severity, respiratory dysfunction, and steroid use.
Source: Journal of Allergy and Clinical Immunology - September 4, 2017 Category: Allergy & Immunology Authors: Trisha Basu, Seyedmojtaba Seyedmousavi, Janyce A. Sugui, Nariman Balenga, Ming Zhao, Kyung Joo Kwon Chung, Sabrina Biardel, Michel Laviolette, Kirk M. Druey Source Type: research

Basophil activation test determination of CD63 combined with CD203c is not superior to CD203c alone in identifying ABPA in cystic fibrosis
CD203c level at the surface of allergen-activated basophils is the best marker to identify allergic bronchopulmonary aspergillosis (ABPA) and discriminate from Aspergillus fumigatus colonization in patients with cystic fibrosis.
Source: Journal of Allergy and Clinical Immunology - April 20, 2016 Category: Allergy & Immunology Authors: Yael Gernez, Jeffrey Walters, Rabindra Tirouvanziam, Leonore A. Herzenberg, Richard B. Moss Source Type: research

Basophil activation test determination of CD63 combined with CD203c is not superior to CD203c alone in identifying allergic bronchopulmonary aspergillosis in cystic fibrosis
We would like to comment on the letter from Chirumbolo1 regarding the work of our collaborators Mirkovic et  al.2 Mirkovic et al demonstrated that Aspergillus fumigatus–sensitized individuals display an increased upregulation of the surface-expressed basophil marker CD203c in response to ex vivo challenge with A fumigatus extract, a response readily measurable by flow cytometry in the basophil activa tion test (BAT). However, Mirkovic et al did not report on evaluation of basophil CD63 expression, which is also upregulatd by allergen challenge, as shown in our previous published work.
Source: Journal of Allergy and Clinical Immunology - April 20, 2016 Category: Allergy & Immunology Authors: Yael Gernez, Jeffrey Waters, Rabindra Tirouvanziam, Leonore Herzenberg, Richard Moss Tags: Letter to the Editor Source Type: research

Calcineurin inhibitors impair neutrophil activity against Aspergillus fumigatus in allogenic hematopoietic stem cell transplant recipients
In allogenic hematopoietic stem cell transplant recipients, fungal innate immunity driven by neutrophils is altered during the first months of the graft, in relation with the use of calcineurin inhibitors.
Source: Journal of Allergy and Clinical Immunology - April 5, 2016 Category: Allergy & Immunology Authors: Sébastien Imbert, Priscillia Bresler, Alexandre Boissonnas, Lauraine Gauthier, Laëtitia Souchet, Madalina Uzunov, Véronique Leblond, Dominique Mazier, Stéphanie Nguyen, Arnaud Fekkar Source Type: research

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