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Source: Journal of Immunology Research
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Total 47 results found since Jan 2013.
S100A9 Regulated M1/M2 Macrophage Polarization in Interleukin-10-Induced Promotion of Malignant Pleural Effusion
In conclusion, S100A9 plays a vital role in the process of IL-10 deficiency-mediated MPE suppression by regulating M1/M2 polarization, thus influencing the tumor-migration capacity and apoptosis. This could result in clinically applicable strategies to inhibit the formation of MPE by regulating the polarization of MPE macrophages.PMID:37533789 | PMC:PMC10393522 | DOI:10.1155/2023/3473464
Source: Journal of Immunology Research - August 3, 2023 Category: Allergy & Immunology Authors: Xue-Bin Pei Feng-Shuang Yi Shu-Feng Dong Qing-Yu Chen Xin-Yu Shi Source Type: research
Decreased Jumonji Domain-Containing 3 at the Promoter Downregulates Hematopoietic Progenitor Kinase 1 Expression and Cytoactivity of T Follicular Helper Cells from Systemic Lupus Erythematosus Patients
J Immunol Res. 2022 Sep 28;2022:3690892. doi: 10.1155/2022/3690892. eCollection 2022.ABSTRACTT follicular helper (Tfh) cells are overactivated in systemic lupus erythematosus (SLE) patients and contribute to excessive immunity. Hematopoietic progenitor kinase 1 (HPK1), as an inhibitor of T cells, is underexpressed in SLE Tfh cells and consequently induces autoimmunity. However, the reason for downregulation of HPK1 in SLE Tfh cells remains elusive. By combining chromatin immunoprecipitation with quantitative polymerase chain reaction assays, it was found that histone H3 lysine 27 trimethylation (H3K27me3) at the HPK1 promo...
Source: Journal of Immunology Research - October 10, 2022 Category: Allergy & Immunology Authors: Shuaihantian Luo Yuming Xie Junke Huang Juan Liu Qing Zhang Source Type: research
The MicroRNA-106a/20b Strongly Enhances the Antitumour Immune Responses of Dendritic Cells Pulsed with Glioma Stem Cells by Targeting STAT3
CONCLUSIONS: This study indicted that the miR-106a/20b activation could be one of the important molecular mechanisms leading to enhance antitumour immune responses of GSC-mediated DCs, which downregulated the expression of STAT3 to alleviate its the inhibitory effect.PMID:36157880 | PMC:PMC9499788 | DOI:10.1155/2022/9721028
Source: Journal of Immunology Research - September 26, 2022 Category: Allergy & Immunology Authors: Hui Zhou Chengmei Sun Cong Li Shiting Hua Feng Li Ruichun Li Dongpeng Cai Yuxi Zou Yingqian Cai Xiaodan Jiang Source Type: research
C/EBP < em > α < /em > -Mediated Transcriptional Activation of PIK3C2A Regulates Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection
CONCLUSION: Our data indicated that during the development of AD, C/EBPα regulated the transition of VSMC phenotype and extracellular matrix remodeling by activating autophagy through regulating the transcriptional activity of PIK3C2A promoter.PMID:36132983 | PMC:PMC9484969 | DOI:10.1155/2022/7465353
Source: Journal of Immunology Research - September 22, 2022 Category: Allergy & Immunology Authors: Heng Lu Yi Chen Yinhai Chen Lingchen Huang Liangwan Chen Source Type: research
The Long Noncoding RNA MEG3 Retains Epithelial-Mesenchymal Transition by Sponging miR-146b-5p to Regulate SLFN5 Expression in Breast Cancer Cells
J Immunol Res. 2022 Aug 18;2022:1824166. doi: 10.1155/2022/1824166. eCollection 2022.ABSTRACTMore and more studies have shown that long noncoding RNAs (lncRNAs) play essential roles in malignant tumors. The lncRNA MEG3 serves as a crucial molecule in breast cancer development, but the specific molecular mechanism needs to be further explored. We previously reported that Schlafen family member 5 (SLFN5) inhibits breast cancer malignant development by regulating epithelial-mesenchymal transition (EMT), invasion, and proliferation/apoptosis. Herein, we demonstrated that MEG3 was downregulated in pan-cancers and correlated wit...
Source: Journal of Immunology Research - August 29, 2022 Category: Allergy & Immunology Authors: Xuefeng Gu Jingyi Li Xiaojia Zuo Kaijie Chen Guoqing Wan Li-Li Deng Weiming Zhao Changlian Lu Source Type: research
Immunogenomic-Based Analysis of Hierarchical Clustering of Diffuse Large Cell Lymphoma
J Immunol Res. 2022 Aug 9;2022:9544827. doi: 10.1155/2022/9544827. eCollection 2022.ABSTRACTDiffuse large B cell lymphoma (DLBCL) is one of the most usual types of adult lymphoma with heterogeneousness in histological morphology, prognosis, and clinical indications. Prior to this, several studies were carried out to determine the DLBCL subtype based on the analysis of the genome profile. However, classification based on assessment of genes related to the immune system has limited clinical significance for DLBCL. We systematically explored the DLBCL gene expression dataset and provided publicly available clinical informatio...
Source: Journal of Immunology Research - August 19, 2022 Category: Allergy & Immunology Authors: Longhao Wang Wei Yuan Lifeng Li Zhibo Shen Qishun Geng Yuanyuan Zheng Jie Zhao Source Type: research
