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Source: Current Eye Research
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Total 374 results found since Jan 2013.
A novel primary porcine retinal pigment epithelium cell model with preserved properties
CONCLUSIONS: This work describes, for the first time, a pRPE cell model that exhibits preserved RPE properties for several passages on cell culture plastic plates. Though RPE characteristics were maintained for at least 6 passages, the reduced CRALBP and RPE-65 with passaging emphasize that lower passage cells are advantageous to utilise, and that morphology, barrier function and ZO-1 localisation cannot be solely employed as a quality measure of RPE identity. Pigs are phylogenetically similar to humans, including similar physiology, anatomy and immune system. Therefore, porcine RPE cells constitute a relevant model system...
Source: Current Eye Research - September 19, 2023 Category: Opthalmology Authors: Dinna Zhou Anne Petersen Julia Adel öf Malin Hernebring Madeleine Zetterberg Source Type: research
Honokiol Attenuates Choroidal Neovascularization by Inhibiting the Hypoxia-inducible Factor- α/Vascular Endothelial Growth Factor Axis via Nuclear transcription factor-kappa B Activation
CONCLUSION: We demonstrated that honokiol attenuated CNV formation by inactivating the HIF-1α/VEGF axis through NF-κB signaling pathway.PMID:37707827 | DOI:10.1080/02713683.2023.2259634
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Ningxin Pan Jian Shi Shu Du Zhaoxian Qiu Qiliang Ran Yangchen Guo Anping Ma Qi Zhang Aimin Sang Xiaowei Yang Source Type: research
Hydrogen Peroxide Affects the Electroretinogram of Isolated Perfused Rat Retina
CONCLUSIONS: H2O2 affects retinal function as shown by ERGs in isolated rat retina. The response differs with the dose of H2O2, suggesting that mechanisms underlying the action at low doses might be different from those at high doses. Our results also suggest an effect of H2O2 on ionic currents and/or neurotransmitter releases involved in the generation of the ERG and indicate a more pronounced effect on photoreceptors than on postsynaptic cells.PMID:37706511 | DOI:10.1080/02713683.2023.2256029
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Nathalie Jacquemot Eric Wersinger Philippe Brabet David Cia Source Type: research
Honokiol Attenuates Choroidal Neovascularization by Inhibiting the Hypoxia-inducible Factor- α/Vascular Endothelial Growth Factor Axis via Nuclear transcription factor-kappa B Activation
CONCLUSION: We demonstrated that honokiol attenuated CNV formation by inactivating the HIF-1α/VEGF axis through NF-κB signaling pathway.PMID:37707827 | DOI:10.1080/02713683.2023.2259634
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Ningxin Pan Jian Shi Shu Du Zhaoxian Qiu Qiliang Ran Yangchen Guo Anping Ma Qi Zhang Aimin Sang Xiaowei Yang Source Type: research
Hydrogen Peroxide Affects the Electroretinogram of Isolated Perfused Rat Retina
CONCLUSIONS: H2O2 affects retinal function as shown by ERGs in isolated rat retina. The response differs with the dose of H2O2, suggesting that mechanisms underlying the action at low doses might be different from those at high doses. Our results also suggest an effect of H2O2 on ionic currents and/or neurotransmitter releases involved in the generation of the ERG and indicate a more pronounced effect on photoreceptors than on postsynaptic cells.PMID:37706511 | DOI:10.1080/02713683.2023.2256029
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Nathalie Jacquemot Eric Wersinger Philippe Brabet David Cia Source Type: research
Honokiol Attenuates Choroidal Neovascularization by Inhibiting the Hypoxia-inducible Factor- α/Vascular Endothelial Growth Factor Axis via Nuclear transcription factor-kappa B Activation
CONCLUSION: We demonstrated that honokiol attenuated CNV formation by inactivating the HIF-1α/VEGF axis through NF-κB signaling pathway.PMID:37707827 | DOI:10.1080/02713683.2023.2259634
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Ningxin Pan Jian Shi Shu Du Zhaoxian Qiu Qiliang Ran Yangchen Guo Anping Ma Qi Zhang Aimin Sang Xiaowei Yang Source Type: research
Hydrogen Peroxide Affects the Electroretinogram of Isolated Perfused Rat Retina
CONCLUSIONS: H2O2 affects retinal function as shown by ERGs in isolated rat retina. The response differs with the dose of H2O2, suggesting that mechanisms underlying the action at low doses might be different from those at high doses. Our results also suggest an effect of H2O2 on ionic currents and/or neurotransmitter releases involved in the generation of the ERG and indicate a more pronounced effect on photoreceptors than on postsynaptic cells.PMID:37706511 | DOI:10.1080/02713683.2023.2256029
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Nathalie Jacquemot Eric Wersinger Philippe Brabet David Cia Source Type: research
Honokiol Attenuates Choroidal Neovascularization by Inhibiting the Hypoxia-inducible Factor- α/Vascular Endothelial Growth Factor Axis via Nuclear transcription factor-kappa B Activation
CONCLUSION: We demonstrated that honokiol attenuated CNV formation by inactivating the HIF-1α/VEGF axis through NF-κB signaling pathway.PMID:37707827 | DOI:10.1080/02713683.2023.2259634
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Ningxin Pan Jian Shi Shu Du Zhaoxian Qiu Qiliang Ran Yangchen Guo Anping Ma Qi Zhang Aimin Sang Xiaowei Yang Source Type: research
Hydrogen Peroxide Affects the Electroretinogram of Isolated Perfused Rat Retina
CONCLUSIONS: H2O2 affects retinal function as shown by ERGs in isolated rat retina. The response differs with the dose of H2O2, suggesting that mechanisms underlying the action at low doses might be different from those at high doses. Our results also suggest an effect of H2O2 on ionic currents and/or neurotransmitter releases involved in the generation of the ERG and indicate a more pronounced effect on photoreceptors than on postsynaptic cells.PMID:37706511 | DOI:10.1080/02713683.2023.2256029
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Nathalie Jacquemot Eric Wersinger Philippe Brabet David Cia Source Type: research
Honokiol Attenuates Choroidal Neovascularization by Inhibiting the Hypoxia-inducible Factor- α/Vascular Endothelial Growth Factor Axis via Nuclear transcription factor-kappa B Activation
CONCLUSION: We demonstrated that honokiol attenuated CNV formation by inactivating the HIF-1α/VEGF axis through NF-κB signaling pathway.PMID:37707827 | DOI:10.1080/02713683.2023.2259634
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Ningxin Pan Jian Shi Shu Du Zhaoxian Qiu Qiliang Ran Yangchen Guo Anping Ma Qi Zhang Aimin Sang Xiaowei Yang Source Type: research
Hydrogen Peroxide Affects the Electroretinogram of Isolated Perfused Rat Retina
CONCLUSIONS: H2O2 affects retinal function as shown by ERGs in isolated rat retina. The response differs with the dose of H2O2, suggesting that mechanisms underlying the action at low doses might be different from those at high doses. Our results also suggest an effect of H2O2 on ionic currents and/or neurotransmitter releases involved in the generation of the ERG and indicate a more pronounced effect on photoreceptors than on postsynaptic cells.PMID:37706511 | DOI:10.1080/02713683.2023.2256029
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Nathalie Jacquemot Eric Wersinger Philippe Brabet David Cia Source Type: research
Discernibility of the Interdigitation Zone (IZ), a Potential Optical Coherence Tomography (OCT) Biomarker for Visual Dysfunction in Aging
CONCLUSIONS: Results suggest that the interface between outer segments and apical processes degrades in normal aging, potentially contributing to delayed rod-mediated dark adaptation. More research is needed to verify an age-related association between IZ discernibility and rod-mediated dark adaptation. If confirmed in a large sample, IZ discernibility might prove to be a valuable biomarker and predictor for visual function in aging.PMID:37539829 | DOI:10.1080/02713683.2023.2240547
Source: Current Eye Research - August 4, 2023 Category: Opthalmology Authors: Andreas Berlin Emily Matney Skyler G Jones Mark E Clark Thomas A Swain Gerald McGwin Richard M Martindale Kenneth R Sloan Cynthia Owsley Christine A Curcio Source Type: research
