Filtered By:
Source: Journal of Neuroinflammation

This page shows you your search results in order of date.

Order by Relevance | Date

Total 18 results found since Jan 2013.

Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFα in vitro
Conclusions: These findings implicate microglia-derived TNFα as a mediator of nPM in air pollution-associated neurodegenerative changes which alter synaptic functions and neuronal growth.
Source: Journal of Neuroinflammation - January 26, 2016 Category: Neurology Authors: Hank ChengDavid DavisSina HasheminassabConstantinos SioutasTodd MorganCaleb Finch Source Type: research

NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1
Conclusions: These results suggest that TNFα induces PARP-1 activation through a signaling pathway involving TNFR1, Ca 2+ influx, activation of PC-PLC, and activation of the MEK1 / ERK2 protein kinase cascade. TNFα-induced PARP-1 activation is not associated with DNA damage, but ERK2 mediated phosphorylation of PARP-1.
Source: Journal of Neuroinflammation - December 4, 2015 Category: Neurology Authors: Billy VuongAdam Hogan-CannConrad AlanoMackenzie StevensonWai ChanChristopher AndersonRaymond SwansonTiina Kauppinen Source Type: research

Cytosolic phospholipase A 2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway
Conclusions: In summary, the results in this study demonstrated the role of cPLA 2 in microglial activation with metabolic links to oxidative and inflammatory responses, and this was in part regulated by the AA metabolic pathways, namely the LOXs. Further studies with targeted inhibition of cPLA 2 /LOX in microglia during neuroinflammatory conditions can be valuable to investigate the therapeutic potential in ameliorating neurological disease pathology.
Source: Journal of Neuroinflammation - October 31, 2015 Category: Neurology Authors: Dennis ChuangAgnes SimonyiPaul KotzbauerZezong GuGrace Sun Source Type: research

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite
Conclusions: Our findings implicate that P2X7R exacerbated inflammatory progression and brain damage in ICH rats possibly via NLRP3 inflammasome-dependent IL-1β/IL-18 release and neutrophil infiltration. ONOO − , a potential downstream signaling molecule of P2X7R, may play a critical role in triggering NLRP3 inflammasome activation.
Source: Journal of Neuroinflammation - October 17, 2015 Category: Neurology Authors: Liang FengYizhao ChenRui DingZhenghao FuShuo YangXinqing DengJun Zeng Source Type: research

Role of high-mobility group box 1 in methamphetamine-induced activation and migration of astrocytes
Conclusions: This study demonstrated that methamphetamine-mediated activation and migration of astrocytes involved HMGB1 up-regulation through an autocrine mechanism. Targeting HMGB1 could provide insights into the development of a potential therapeutic approach for alleviation of cell activation and migration of astrocytes induced by methamphetamine.
Source: Journal of Neuroinflammation - September 4, 2015 Category: Neurology Authors: Yuan ZhangTiebing ZhuXiaotian ZhangJie ChaoGang HuHonghong Yao Source Type: research

Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3
Conclusions: These results demonstrate that the enhanced excitability produced by S1P is mediated by activation of S1PR1 and/or S1PR3.
Source: Journal of Neuroinflammation - April 12, 2015 Category: Neurology Authors: Chao LiJun-nan LiJoanne KaysMiguel GuerreroGrant Nicol Source Type: research

Inflammatory mediator release from primary rhesus microglia in response to Borrelia burgdorferi results from the activation of several receptors and pathways
Conclusions: Several receptors and pathways, with both positive and negative effects, mediate inflammation of primary microglia in response to B. burgdorferi, resulting in a complex, tightly regulated immune network.
Source: Journal of Neuroinflammation - March 28, 2015 Category: Neurology Authors: Geetha ParthasarathyMario Philipp Source Type: research

CCAAT/enhancer binding protein ß directly regulates the expression of the complement component 3 gene in neural cells: implications for the pro-inflammatory effects of this transcription factor
Conclusions: Altogether, these results indicate that C3 is a downstream target of C/EBP?, and it could be a mediator of the pro-inflammatory effects of this transcription factor in neural cells.
Source: Journal of Neuroinflammation - January 24, 2015 Category: Neurology Authors: Elena Hernandez-EncinasDiana Aguilar-MoranteMarta Cortes-CanteliJose Morales-GarciaElena GineAngel SantosAna Perez-Castillo Source Type: research

Molecular mechanisms involved in HIV-1 Tat-mediated induction of IL-6 and IL-8 in astrocytes
Conclusion: Our results demonstrate HIV-1 Tat-mediated induction of both IL-6 and IL-8 in a time-dependent manner in SVG astrocytes. Furthermore, we also showed the involvement of NF-?B and AP-1 transcription factors regulated by PI3/Akt, p38 MAPK and JNK MAPK upstream signaling molecules. These results present new therapeutic targets that could be used in management of HAND.
Source: Journal of Neuroinflammation - December 24, 2014 Category: Neurology Authors: Anantha NookalaAnil Kumar Source Type: research

Expression of 2¿,3¿-cyclic nucleotide 3¿-phosphodiesterase (CNPase) and its roles in activated microglia
Conclusions: The present results have provided the first morphological and molecular evidence that CNPase expression is increased in activated microglia. CNPase knockdown resulted in increased expression of various inflammatory mediators. It is concluded that CNPase may play an important role as a putative anti-inflammatory gene both in normal and injured brain.
Source: Journal of Neuroinflammation - August 23, 2014 Category: Neurology Authors: Lijuan YangEnci KanJia LuChunyun WuEng-Ang Ling Source Type: research

Rcor2 underexpression in senescent mice: a target for inflammaging?
Conclusions: Data presented here show interplay between Rcor2 downregulation and increased inflammation and suggest that Rcor2 may be a key regulator of inflammaging.
Source: Journal of Neuroinflammation - July 23, 2014 Category: Neurology Authors: María Alvarez-LópezPatricia Molina-MartínezMarco Castro-FreireMarta Cosín-TomásRosa CristòfolMarcelina PárrizasRosa EscorihuelaMerce PallàsCoral SanfeliuPerla Kaliman Source Type: research

Inhibitory effect of ent-Sauchinone on amyloidogenesis via inhibition of STAT3-mediated NF-¿B activation in cultured astrocytes and microglial BV-2 cells
Conclusions: These results indicated that ent-Sauchinone inhibited neuroinflammation and amyloidogenesis through the inhibition of STAT3-mediated NF-kappaB activity, and thus could be applied in the treatment of neuro-inflammatory diseases, including Alzheimer's disease.
Source: Journal of Neuroinflammation - July 2, 2014 Category: Neurology Authors: Suk-Young SongYu JungChul HwangHee LeeChang SokJoo KimSang LeeHyun SeoByung HyunDong ChoiSang HanYoung HamBang HwangJin Hong Source Type: research

Inhibitory effect of ent-Sauchinone on amyloidogenesis via inhibition of STAT3-mediated NF-kappaB activation in cultured astrocytes and microglial BV-2 cells
Conclusions: These results indicated that ent-Sauchinone inhibited neuroinflammation and amyloidogenesis through the inhibition of STAT3-mediated NF-kappaB activity, and thus could be applied in the treatment of neuro-inflammatory diseases, including Alzheimer's disease.
Source: Journal of Neuroinflammation - July 2, 2014 Category: Neurology Authors: Suk-Young SongYu JungChul HwangHee LeeChang SokJoo KimSang LeeHyun SeoByung HyunDong ChoiSang HanYoung HamBang HwangJin Hong Source Type: research

The anti-inflammatory role of tissue inhibitor of metalloproteinase-2 in lipopolysaccharide-stimulated microglia
Conclusions: Enhancement of TIMP-2 expression may be a potential therapeutic target for neuroinflammatory disorders.
Source: Journal of Neuroinflammation - June 27, 2014 Category: Neurology Authors: Eun-Jung LeeHee-Sun Kim Source Type: research

Interleukin-1 beta guides the migration of cortical neurons
Conclusions: Our study suggests an essential contribution of IL-1beta to neuronal migration during brain development, which provides a basis to understand the physiological roles of IL-1beta in the developing brain and could have significant implications for the prevention of some neurodevelopment disorders due to abnormal neuronal migration.
Source: Journal of Neuroinflammation - June 21, 2014 Category: Neurology Authors: Lei MaXiao-wei LiShi-jun ZhangFeng YangGe-min ZhuXiao-bing YuanWen Jiang Source Type: research