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Combination of Quercetin or/and siRNA-loaded DDAB-mPEG-PCL hybrid nanoparticles reverse resistance to Regorafenib in colon cancer cells
Colorectal cancer (CRC) is the second leading cause of cancer death. Although Regorafenib showed survival benefits in patients with CRC, reports imply the recurrence of malignant phenotype resulting from chemo...
Source: BMC Complementary and Alternative Medicine - December 27, 2022 Category: Complementary Medicine Authors: Shabnam Shahidi, Kobra Rostamizadeh, Mojtaba Fathi, Keivan Nedaei and Ali Ramazani Tags: Research Source Type: research

Qian Yang Yu Yin Granule-containing serum inhibits angiotensin II-induced proliferation, reactive oxygen species production, and inflammation in human mesangial cells via an NADPH oxidase 4-dependent pathway
Conclusions: Taken together, these results suggest that a NOX4-dependent pathway plays an important role in regulating the inhibitory effect of QYGS. Our findings provide new insights into the molecular mechanisms of QYYYG and their role in the treatment of hypertensive nephropathy.
Source: BMC Complementary and Alternative Medicine - March 25, 2015 Category: Complementary Medicine Authors: Kang DingYan WangWeimin JiangYu ZhangHongping YinZhuyuan Fang Source Type: research

The induction of activating transcription factor 3 (ATF3) contributes to anti-cancer activity of Abeliophyllum distichum Nakai in human colorectal cancer cells
Conclusion: These findings suggest that the anti-cancer activity of EAFAD-B may be a result of ATF3 promoter activation and subsequent increase of ATF3 expression.
Source: BMC Complementary and Alternative Medicine - December 15, 2014 Category: Complementary Medicine Authors: Gwang Hun ParkJae Ho ParkHyun Ji EoHun Min SongSo Hee WooMi Kyoung KimJin Wook LeeMan Hyo LeeJeong Rak LeeJin Suk KooJin Boo Jeong Source Type: research

Ganoderma lucidum inhibits proliferation of human ovarian cancer cells by suppressing VEGF expression and up-regulating the expression of connexin 43
Conclusions: G. lucidum inhibits ovarian cancer by down-regulating the expression of VEGF and up-regulating the downstream Cx43 expression. G. lucidum may be a promising therapeutic agent for the treatment of ovarian cancer.
Source: BMC Complementary and Alternative Medicine - November 5, 2014 Category: Complementary Medicine Authors: Shuyan DaiJingjing LiuXiaofei SunNing Wang Source Type: research

Anti-cancer activity of Ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells
Conclusions: These findings suggest that the reduction of cell viability and apoptosis by GL may be a result of ATF3 promoter activation and subsequent increase of ATF3 expression through ERK1/2 activation in human colorectal cancer cells.
Source: BMC Complementary and Alternative Medicine - October 23, 2014 Category: Complementary Medicine Authors: Gwang Hun ParkJae Ho ParkHun Min SongHyun Ji EoMi Kyoung KimJin Wook LeeMan Hyo LeeKiu-Hyung ChoJeong Rak LeeHyeon Je ChoJin Boo Jeong Source Type: research

Cephalotaxus griffithii Hook.f. needle extract induces cell cycle arrest, apoptosis and suppression of hTERT and hTR expression on human breast cancer cells
Conclusion: Based on the observations, we concluded that PE extract of C. griffithii needle contains important phyto-components with multiple cellular targets for control of breast cancer and is worthy of future studies.
Source: BMC Complementary and Alternative Medicine - August 18, 2014 Category: Complementary Medicine Authors: Dinesh MoirangthemSurbala LaishramJagat BorahMohan KalitaNarayan Talukdar Source Type: research

Essential oil of Pinus koraiensis inhibits cell proliferation and migration via inhibition of p21-activated kinase 1 pathway in HCT116 colorectal cancer cells
Conclusions: Our studies indicate that EOPK significantly reduced proliferation and migration of colorectal cancer cells. Furthermore, EOPK suppressed PAK1 expression in a dose-dependent manner, and this suppression of PAK1 led to inhibition of ERK, AKT, and beta-catenin activities. Our findings suggest that EOPK exerts its anticancer activity via the inhibition of PAK1 expression, suggesting it may be a potent chemotherapeutic agent for colorectal cancer.
Source: BMC Complementary and Alternative Medicine - July 30, 2014 Category: Complementary Medicine Authors: Sun-Mi ChoEun-Ok LeeSung-Hoon KimHyo-Jeong Lee Source Type: research

Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells
Conclusions: In summary, these data indicate that Khz-cp preferentially induces apoptosis in cancer cells and that the signaling mechanisms involve an increase in [Ca2+]i, P38 activation, and ROS generation via NADPH oxidase and mitochondria.
Source: BMC Complementary and Alternative Medicine - July 10, 2014 Category: Complementary Medicine Authors: Tae KimJu KimZoo KimRen HuangYoung ChaeRen Wang Source Type: research

The involvement of AMPK/GSK3-beta signals in the control of metastasis and proliferation in hepato-carcinoma cells treated with anthocyanins extracted from Korea wild berry Meoru
Conclusion: These observations imply that the AMPK-mediated GSK3-beta/beta-catenin circuit plays crucial roles in inhibiting cancer cell proliferation and metastasis in anthocyanin-treated hepato-carcinoma cells of Meoru origin.
Source: BMC Complementary and Alternative Medicine - March 25, 2014 Category: Complementary Medicine Authors: Song Yi ParkYun-Kyoung LeeWon Sup LeeOck Jin ParkYoung-Min Kim Source Type: research

Isoquercitrin activates the AMP¿activated protein kinase (AMPK) signal pathway in rat H4IIE cells
Conclusions: Isoquercitrin appears to regulate AMPK activation, thereby enhancing AdipoR1 expression, suppressing SREBP-1 and FAS expressions, and resulting in the regulation of lipid accumulation. These results suggest that isoquercitrin is a novel dietary compound that can be potentially be used to prevent lipid metabolic disorder and nonalcoholic fatty liver disease.
Source: BMC Complementary and Alternative Medicine - February 3, 2014 Category: Complementary Medicine Authors: Jingxin ZhouHisae YoshitomiTonghua LiuBoxin ZhouWen SunLingling QinXiangyu GuoLiansha HuangLili WuMing Gao Source Type: research

Isoquercitrin activates the AMP-activated protein kinase (AMPK) signal pathway in rat H4IIE cells
Conclusions: Isoquercitrin appears to regulate AMPK activation, thereby enhancing AdipoR1 expression, suppressing SREBP-1 and FAS expressions, and resulting in the regulation of lipid accumulation. These results suggest that isoquercitrin is a novel dietary compound that can be potentially be used to prevent lipid metabolic disorder and nonalcoholic fatty liver disease.
Source: BMC Complementary and Alternative Medicine - February 3, 2014 Category: Complementary Medicine Authors: Jingxin ZhouHisae YoshitomiTonghua LiuBoxin ZhouWen SunLingling QinXiangyu GuoLiansha HuangLili WuMing Gao Source Type: research