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Source: Cancer Control
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Total 159 results found since Jan 2013.
Ultrathin SU-8 membrane for highly efficient tunable cell patterning and massively parallel large biomolecular delivery
This study presents a novel and efficient technique that enables massively parallel high throughput cell patterning and precise delivery of small to large biomolecules into patterned cells. The innovative cell patterning device proposed in this study is a standalone, ultrathin 3D SU-8 micro-stencil membrane, with a thickness of 10 μm. It features an array of micro-holes ranging from 40 μm to 80 μm, spaced apart by 50 μm to 150 μm. By culturing cells on top of this SU-8 membrane, the technique achieves highly efficient cell patterns varying from single-cell to cell clusters on a Petri dish. Utilizing this technique, we...
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Pallavi Shinde Ashwini Shinde Srabani Kar Kavitha Illath Moeto Nagai Fan-Gang Tseng Tuhin Subhra Santra Source Type: research
TRIM65 Suppresses oxLDL-induced Endothelial Inflammation by Interaction with VCAM-1 in Atherogenesis
CONCLUSION: Our studies indicate that TRIM65 attenuates the endothelial inflammatory response by targeting VCAM-1 for ubiquitination and provides a potential therapeutic target for the inhibition of endothelial inflammation in AS.PMID:37608612 | DOI:10.2174/0929867331666230822152350
Source: Cancer Control - August 23, 2023 Category: Cancer & Oncology Authors: Xiao-Feng Ma Yi-Ren Zhou Zhi-Xiang Zhou Hui-Ting Liu Bo-Bin Zhoua Nian-Hua Deng Kun Zhou Zhen Tian Ze-Fan Wu Xi-Yan Liu Ming-Gui Fu Zhi-Sheng Jiang Source Type: research
Inhibition of VCP modulates NF- κB signaling pathway to suppress multiple myeloma cell proliferation and osteoclast differentiation
This study aims to identify if VCP is a therapeutic target in MM and confirm the effect of a novel inhibitor of VCP (VCP20) on MM. We found that VCP was elevated in MM patients and correlated with shorter survival in clinical TT2 cohort. Silencing VCP using siRNA resulted in decreased MM cell proliferation via NF-κB signaling pathway. VCP20 evidently inhibited MM cell proliferation and osteoclast differentiation. Moreover, exosomes containing VCP derived from MM cells partially alleviated the inhibitory effect of VCP20 on cell proliferation and osteoclast differentiation. Mechanism study revealed that VCP20 inactivated th...
Source: Cancer Control - August 22, 2023 Category: Cancer & Oncology Authors: Rongfang Wei Yuhao Cao Hongjie Wu Xin Liu Mingmei Jiang Xian Luo Zhendong Deng Ze Wang Mengying Ke Yongqiang Zhu Siqing Chen Chunyan Gu Ye Yang Source Type: research
Lipid-Polymer Hybrid Nanoparticles with Both PD-L1 Knockdown and Mild Photothermal Effect for Tumor Photothermal Immunotherapy
In this study, dopamine-modified polyethylenimine (PEI) was prepared to fabricate an IR780 and siPD-L1 codelivery lipid-polymer hybrid nanoparticle (lip@PSD-siP) for the photothermal immunotherapy of CRC. The modification of dopamine can significantly reduce the cytotoxicity of PEI. lip@PSD-siP can be effectively taken up by CT26 cells and successfully escaped from lysosomes after entering the cells for 4 h. After CT26 cells were transfected with lip@PSD-siP, the PD-L1 positive cell rate decreased by 82.4%, and its PD-L1 knockdown effect was significantly stronger than the positive control Lipo3000-siP. In vivo studies sho...
Source: Cancer Control - August 22, 2023 Category: Cancer & Oncology Authors: Di Chuan Rangrang Fan Bo Chen Yangmei Ren Min Mu Haifeng Chen Bingwen Zou Haohao Dong Aiping Tong Gang Guo Source Type: research
Regulation of cellular contractile force, shape and migration of fibroblasts by oncogenes and Histone deacetylase 6
Front Mol Biosci. 2023 Jul 20;10:1197814. doi: 10.3389/fmolb.2023.1197814. eCollection 2023.ABSTRACTThe capacity of cells to adhere to, exert forces upon and migrate through their surrounding environment governs tissue regeneration and cancer metastasis. The role of the physical contractile forces that cells exert in this process, and the underlying molecular mechanisms are not fully understood. We, therefore, aimed to clarify if the extracellular forces that cells exert on their environment and/or the intracellular forces that deform the cell nucleus, and the link between these forces, are defective in transformed and inv...
Source: Cancer Control - August 11, 2023 Category: Cancer & Oncology Authors: Ana L ópez-Guajardo Azeer Zafar Khairat Al Hennawi Valentina Rossi Abdulaziz Alrwaili Jessica D Medcalf Mark Dunning Niklas Nordgren Torbj örn Pettersson Ian D Estabrook Rhoda J Hawkins Annica K B Gad Source Type: research
Homotypic targeted nanoplatform enable efficient chemoimmunotherapy and reduced DOX cardiotoxicity in chemoresistant cancer via TGF- β1 blockade
J Control Release. 2023 Aug 1:S0168-3659(23)00486-8. doi: 10.1016/j.jconrel.2023.07.063. Online ahead of print.ABSTRACTDoxorubicin (DOX) with broad-spectrum antitumor activity has been reported to induce effective immunogenic cell death (ICD) effect. However, the serious cardiotoxicity and chemoresistance severely restrict the widely clinical application of DOX. Herein, for the first time, a bio-inspired nanoplatform via co-assembly of DOX-conjugated polyethyleneimine (PEI-DOX), cancer cell membrane (CCM) and TGF-β1 siRNA (siTGF-β1) was rationally designed, which can not only overcome the drawbacks of DOX but also displa...
Source: Cancer Control - August 3, 2023 Category: Cancer & Oncology Authors: Nuannuan Li Tianyu Zhang Ru Wang Yiying Sun Liuxiang Chu Xiaoyan Lu Kaoxiang Sun Source Type: research
Stable expression of shRNA for the control of recombinant adenovirus replication
Braz J Med Biol Res. 2023 Jul 21;56:e12682. doi: 10.1590/1414-431X2023e12682. eCollection 2023.ABSTRACTPreventing the replication of adenovirus could have practical uses, such as controlling infection with wild-type virus or in applications involving recombinant vectors. Mainly transient methods have been used to inhibit adenovirus replication, including siRNA or drugs. Here, we tested whether stable expression of shRNA designed to target hexon, Iva2, or pol can inhibit the replication of a recombinant adenoviral vector, Ad-LacZ (serotype 5, E1/E3 deleted), in 293T cells. Significant knockdown correlating with reduced Ad-L...
Source: Cancer Control - July 26, 2023 Category: Cancer & Oncology Authors: M V G Lana F Antunes N G Tessarollo B E Strauss Source Type: research
Knockdown of NF- κB activating protein promotes pancreatic cancer growth and metastasis through mTOR signaling pathway
CONCLUSIONS: NKAP as an oncogene regulates the development of PAAD cells. The research found that the mTOR signaling pathway is engaged in the oncogenic role of NKAP in PAAD for the first time.PMID:37486443 | DOI:10.1007/s11033-023-08665-1
Source: Cancer Control - July 24, 2023 Category: Cancer & Oncology Authors: Xiangrong Xu Danyang Hou Yujie Wang Jing Zhang Yu Hei Bobo Wang Shuyue Tian Yunqing Zhang Fenghui Wang Source Type: research
Multiple suppressing small interfering rna for cancer treatment - application to triple-negative breast cancer
This article is protected by copyright. All rights reserved.PMID:37478121 | DOI:10.1002/biot.202300060
Source: Cancer Control - July 21, 2023 Category: Cancer & Oncology Authors: Jaewook Lee Jang Hyuk Bang Yeong Chae Ryu Byeong Hee Hwang Source Type: research
Lipid nanoparticle delivery of siRNA targeting < em > Cyp2e1 < /em > gene attenuates subacute alcoholic liver injury in mice
CONCLUSIONS: The si-Cyp2e1 LNP may attenuate subacute alcoholic liver injury in mice mainly by reducing reactive oxygen levels, increasing antioxidant activity, blocking oxidative stress pathways and reducing ethanol-induced steatosis and inflammation.PMID:37476942 | DOI:10.3724/zdxbyxb-2022-0729
Source: Cancer Control - July 21, 2023 Category: Cancer & Oncology Authors: Shuang Wu Qiubing Chen Yalan Wang Hao Yin Yuan Wei Source Type: research
Cdc42 Regulates the Expression of Cytoskeleton and Microtubule Network Proteins to Promote Invasion and Metastasis of Progeny Cells Derived from CoCl < sub > 2 < /sub > -induced Polyploid Giant Cancer Cells
Conclusion: CoCl2-induced overexpression of Cdc42 plays a critical role in increasing the infiltration and migration abilities of PGCCs and progeny cells by regulating cytoskeleton protein expression.PMID:37476197 | PMC:PMC10355212 | DOI:10.7150/jca.85032
Source: Cancer Control - July 21, 2023 Category: Cancer & Oncology Authors: Minying Zheng Lankai Chen Junjie Fu Xiaohui Yang Shuo Chen Wenzheng Fu Yuwei Li Shiwu Zhang Source Type: research
Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells
CONCLUSIONS/INTERPRETATION: We provide the first account of epigenetic changes in diabetic corneas including dual inhibition of WNT5A by DNA methylation and miRNA action. Overall, Wnt-5a is a new corneal epithelial wound healing stimulator that can be targeted to improve wound healing and stem cells in the diabetic cornea.DATA AVAILABILITY: The DNA methylation dataset is available from the public GEO repository under accession no. GSE229328 ( https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE229328 ).PMID:37460827 | DOI:10.1007/s00125-023-05960-1
Source: Cancer Control - July 17, 2023 Category: Cancer & Oncology Authors: Ruchi Shah Tanya M Spektor Daniel J Weisenberger Hui Ding Rameshwar Patil Cynthia Amador Xue-Ying Song Steven T Chun Jake Inzalaco Sue Turjman Sean Ghiam Jiho Jeong-Kim Sasha Tolstoff Sabina V Yampolsky Onkar B Sawant Yaron S Rabinowitz Ezra Maguen Pedram Source Type: research
Effect of RNAi-Mediated Survivin and Hypoxia-Inducible Factor 1 α Gene Silencing on Proliferation, Invasion, Migration and Apoptosis of Gastric Cancer BGC-823 Cells
Mol Biotechnol. 2023 Jul 13. doi: 10.1007/s12033-023-00786-z. Online ahead of print.ABSTRACTIn order to investigate the effects of RNAi-mediated survivin and hypoxia-inducible factor 1α (HIF-1α) gene silencing on the proliferation and apoptosis of gastric cancer BGC-823 cells, small interfering RNAs (siRNAs) targeting survivin and HIF-1α mRNAs, respectively, as well as scrambled siRNAs (SCRs) were designed and synthesized, namely siRNA-survivin group, siRNA-HIF-1α group, and SCR group. The hypoxia-sensitive gastric cancer BGC-823 cells were identified and transfected in vitro with Hifectin II under hypoxic conditions, ...
Source: Cancer Control - July 13, 2023 Category: Cancer & Oncology Authors: Yupeng Li Yongchao Liu Mingzhu Chang Runhong Mu Jianyu Zhu Source Type: research
The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8)
Autophagy. 2023 Jul 7:1-19. doi: 10.1080/15548627.2023.2229656. Online ahead of print.ABSTRACTApoptosis is a tightly controlled cell death program executed by proteases, the so-called caspases. It plays an important role in tissue homeostasis and is often dysregulated in cancer. Here, we identified FYCO1, a protein that promotes microtubule plus end-directed transport of autophagic and endosomal vesicles as a molecular interaction partner of activated CASP8 (caspase 8). The absence of FYCO1 sensitized cells to basal and TNFSF10/TRAIL-induced apoptosis by receptor accumulation and stabilization of the Death Inducing Signali...
Source: Cancer Control - July 7, 2023 Category: Cancer & Oncology Authors: Valeria Coppola Ilaria Marino Uwe Warnken Mario Falchi Luca Pasquini Mauro Biffoni Ruggero De Maria Tobias Longin Haas Source Type: research
