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From traditional pharmacological towards nucleic acid-based therapies for cardiovascular diseases
AbstractNucleic acid-based therapeutics are currently developed at large scale for prevention and management of cardiovascular diseases (CVDs), since: (i) genetic studies have highlighted novel therapeutic targets suggested to be causal for CVD; (ii) there is a substantial recent progress in delivery, efficacy, and safety of nucleic acid-based therapies; (iii) they enable effective modulation of therapeutic targets that cannot be sufficiently or optimally addressed using traditional small molecule drugs or antibodies. Nucleic acid-based therapeutics include (i) RNA-targeted therapeutics for gene silencing; (ii) microRNA-mo...
Source: European Heart Journal - April 29, 2020 Category: Cardiology Source Type: research

TRAK2, a novel regulator of ABCA1 expression, cholesterol efflux and HDL biogenesis
ConclusionWe show, for the first time, that TRAK2 is a novel regulator of LXR-mediated ABCA1 expression, cholesterol efflux, and HDL biogenesis. TRAK2 may therefore be an important target in the development of anti-atherosclerotic therapies.
Source: European Heart Journal - June 26, 2017 Category: Cardiology Source Type: research

BDNFVal66met polymorphism: a potential bridge between depression and thrombosis
Conclusion</div>Activation of platelets, alteration in coagulation pathways, and changes in vessel wall protein expression in BDNF^Met/Met mice recapitulate well the features occurring in the anxiety/depression condition. Furthermore, our data suggest that the BDNFVal66Met polymorphism contribute to the individual propensity for arterial thrombosis related to AMI.</span>
Source: European Heart Journal - December 26, 2015 Category: Cardiology Source Type: research

Nano-scale treatment for a macro-scale disease: nanoparticle-delivered siRNA silences CCR2 and treats myocarditis
Source: European Heart Journal - June 14, 2015 Category: Cardiology Authors: Cooper, L. T., Fairweather, D. Tags: EDITORIALS Source Type: research

Silencing of CCR2 in myocarditis
Conclusion This study highlights the importance of CCR2 in the pathogenesis of myocarditis. In addition, we show that siCCR2 affects leucocyte progenitor trafficking. The data also point to a novel therapeutic strategy for the treatment of myocarditis.
Source: European Heart Journal - June 14, 2015 Category: Cardiology Authors: Leuschner, F., Courties, G., Dutta, P., Mortensen, L. J., Gorbatov, R., Sena, B., Novobrantseva, T. I., Borodovsky, A., Fitzgerald, K., Koteliansky, V., Iwamoto, Y., Bohlender, M., Meyer, S., Lasitschka, F., Meder, B., Katus, H. A., Lin, C., Libby, P., Sw Tags: BASIC SCIENCE Source Type: research

Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways
Conclusions Genetic deletion of p66Shc increased susceptibility to myocardial injury in response to short-term ischaemia and reperfusion in mice. Still, additional studies are needed for assessing the role of this pathway in acute coronary syndrome patients.
Source: European Heart Journal - February 21, 2015 Category: Cardiology Authors: Akhmedov, A., Montecucco, F., Braunersreuther, V., Camici, G. G., Jakob, P., Reiner, M. F., Glanzmann, M., Burger, F., Paneni, F., Galan, K., Pelli, G., Vuilleumier, N., Belin, A., Vallee, J.-P., Mach, F., Luscher, T. F. Tags: BASIC SCIENCE Source Type: research

PI3K/p110{alpha} inhibition selectively interferes with arterial thrombosis and neointima formation, but not re-endothelialization: potential implications for drug-eluting stent design
Conclusion Following vascular injury, PI3K/p110α inhibition selectively interferes with arterial thrombosis and neointima formation, but not re-endothelialization. Hence, PI3K/p110α represents an attractive new target in DES design.
Source: European Heart Journal - March 21, 2014 Category: Cardiology Authors: Holy, E. W., Jakob, P., Eickner, T., Camici, G. G., Beer, J. H., Akhmedov, A., Sternberg, K., Schmitz, K.-P., Luscher, T. F., Tanner, F. C. Tags: FASTTRACK CLINICAL RESEARCH Source Type: research

Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury
Conclusion These results demonstrate that nuclear receptor FXR acts as a novel functional receptor in cardiac tissue, regulates apoptosis in cardiomyocytes, and contributes to MI/R injury.
Source: European Heart Journal - June 21, 2013 Category: Cardiology Authors: Pu, J., Yuan, A., Shan, P., Gao, E., Wang, X., Wang, Y., Lau, W. B., Koch, W., Ma, X.-L., He, B. Tags: BASIC SCIENCE Source Type: research

Suppression of persistent atrial fibrillation by genetic knockdown of caspase 3: a pre-clinical pilot study
Conclusion Knockdown of caspase 3 by atrial Ad-siRNA-Cas3 gene transfer suppresses or delays the onset of persistent AF by reduction in apoptosis and prevention of intra-atrial conduction delay in a porcine model. These results highlight the significance of apoptosis in the pathophysiology of AF and demonstrate short-term efficacy of gene therapy for suppression of AF.
Source: European Heart Journal - January 6, 2013 Category: Cardiology Authors: Trappe, K., Thomas, D., Bikou, O., Kelemen, K., Lugenbiel, P., Voss, F., Becker, R., Katus, H. A., Bauer, A. Tags: BASIC SCIENCE Source Type: research